論文

査読有り
2005年12月

Regional cerebral blood flow in Parkinson disease with nonpsychotic visual hallucinations

NEUROLOGY
  • N Oishi
  • ,
  • F Udaka
  • ,
  • M Kameyama
  • ,
  • N Sawamoto
  • ,
  • K Hashikawa
  • ,
  • H Fukuyama

65
11
開始ページ
1708
終了ページ
1715
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1212/01.wnl.0000187116.13370.e0
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Background: Patients with Parkinson disease (PD) often experience visual hallucinations (VH) with retained insight (nonpsychotic) but the precise mechanism remains unclear. Objective: To clarify which neural substrates participate in nonpsychotic VH in PD, the authors evaluated regional cerebral blood flow (rCBF) changes in patients with PD and VH. Methods: The authors compared 24 patients with PD who had nonpsychotic VH ( hallucinators) and 41 patients with PD who had never experienced VH (non-hallucinators) using SPECT images with N-isopropyl-p-[I-123] iodoamphetamine. There were no significant differences in age, sex, duration of disease, doses of PD medications, Hoehn and Yahr scale, or Mini-Mental State Examination (MMSE) scores between the two groups. The rCBF data were analyzed using statistical parametric mapping (SPM). Results: The rCBF in the right fusiform gyrus was lower in the hallucinators than in the non-hallucinators ( corrected p < 0.05 at cluster levels). The hallucinators revealed higher rCBF in the right superior and middle temporal gyri than the non-hallucinators ( uncorrected p < 0.001). These significant differences were demonstrated after MMSE scores and duration of disease, which are the relevant factors associated with VH, were covariated out. Conclusions: Nonpsychotic visual hallucinations in Parkinson disease (PD) may be associated with hypoperfusion in the right fusiform gyrus and hyperperfusion in the right superior and middle temporal gyri. These temporal regions are important for visual object recognition and these regional cerebral blood flow changes are associated with inappropriate visual processing and are responsible for nonpsychotic visual hallucinations in PD.

リンク情報
DOI
https://doi.org/10.1212/01.wnl.0000187116.13370.e0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16344511
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000233898300006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1212/01.wnl.0000187116.13370.e0
  • ISSN : 0028-3878
  • PubMed ID : 16344511
  • Web of Science ID : WOS:000233898300006

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