Norihito Uemura

Profile Information

Affiliation: Kyoto University

Degree: Medicine(Apr, 2015, Kyoto University)

J-GLOBAL ID: 201301063026160041
researchmap Member ID: B000229752

シヌクレイノパチー（パーキンソン病、レビー小体型認知症、多系統萎縮症）のαシヌクレイン伝播に注目し、動物モデル開発と病態解明、そのトランスレーションを目標に研究を行っています。

Research Interests

Research Areas

Research History

Oct, 2023 - Present

Senior Lecturer, Department of Therapeutics for Multiple System Atrophy, Graduate school of medicine, Kyoto University
Oct, 2022 - Sep, 2023

Senior Lecturer, Department of Neurology, Kyoto University Hospital
Jul, 2018 - Sep, 2022

Adjunct Assistant Professor, Center for Neurodegenerative Disease Research, The University of Pennsylvania
Apr, 2015 - Jun, 2018

Assistant Professor, Department of Neurology, Kyoto University Hospital
Apr, 2014 - Mar, 2015

Medical staff, Department of Neurology, Kyoto University Hospital
Apr, 2010 - Mar, 2014

Ph.D. candidate, Department of Neurology, Graduate School of Medicine, Kyoto University
Apr, 2007 - Mar, 2010

Resident, Neurology, Kurashiki Central Hospital
Apr, 2005 - Mar, 2007

Resident, Internal medicine, Shizuoka City Hospital

Papers

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice.

Norihito Uemura, Nicholas P Marotta, Jahan Ara, Emily S Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Q Trojanowski, Virginia M-Y Lee

Nature communications, 14(1) 6892-6892, Oct 28, 2023
Distinct biological activity of Lewy body α-Synuclein strain in mice(タイトル和訳中)

上村紀仁, Marotta Nicholas, Ara Jahan, Meymand Emily, Zhang Bin, 亀田浩司, 小池正人, Luk Kelvin, Trojanowski John, Lee Virginia

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 17回 75-75, Jul, 2023
Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.

Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Ramil Gabdulkhaev, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka …

Proceedings of the National Academy of Sciences of the United States of America, 120(23) e2214652120, Jun 6, 2023
Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission.

Jun Ueda, Norihito Uemura, Tomoyuki Ishimoto, Tomoyuki Taguchi, Masanori Sawamura, Etsuro Nakanishi, Masashi Ikuno, Shuichi Matsuzawa, Hodaka Yamakado, Ryosuke Takahashi

Movement disorders : official journal of the Movement Disorder Society, Apr 17, 2023
Distinct biological activity of Lewy body α-Synuclein strain in mice.

Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin Luk, John Trojanowski, Virginia Lee

Research square, Feb 16, 2023
Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice

Shinya Okuda, Takeo Nakayama, Norihito Uemura, Rie Hikawa, Masashi Ikuno, Hodaka Yamakado, Haruhisa Inoue, Naoko Tachibana, Yu Hayashi, Ryosuke Takahashi …

International Journal of Molecular Sciences, 23(21) 13390-13390, Nov 2, 2022
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.

Masanori Sawamura, Hirotaka Onoe, Hideo Tsukada, Kaoru Isa, Hodaka Yamakado, Shinya Okuda, Masashi Ikuno, Yusuke Hatanaka, Shigeo Murayama, Norihito Uemura …

Movement disorders : official journal of the Movement Disorder Society, Aug 21, 2022
Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease

Maiko T. Uemura, John L. Robinson, Katheryn A. Q. Cousins, Thomas F. Tropea, Daniel C. Kargilis, Jennifer D. McBride, EunRan Suh, Sharon X. Xie, Yan Xu, S{\'{\i } }lvia Porta …

Acta Neuropathologica, Dec 2, 2021 Peer-reviewed
パーキンソン病は消化管起源か?その実験的エビデンス

高橋良輔, 上村紀仁, 山門穂高, 生野真嗣, 澤村正典, 田口智之, 大平純一朗

日本自律神経学会総会プログラム・抄録集, 74回 54-54, Oct, 2021
Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: A metabolomic analysis.

Masashi Ikuno, Hodaka Yamakado, Ikuko Amano, Yusuke Hatanaka, Norihito Uemura, Shu-Ichi Matsuzawa, Ryosuke Takahashi

Neuroscience letters, 765 136267-136267, Sep 24, 2021
非ヒト霊長類におけるα-synuclein嗅覚系伝播とレム睡眠行動異常症

澤村正典, 尾上浩隆, 伊佐かおる, 上村紀仁, 伊佐正, 高橋良輔

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 15回 74-74, Jul, 2021
Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes).

Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-Ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi …

Molecular brain, 14(1) 80-80, May 10, 2021
Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models.

Jun Ueda, Norihito Uemura, Masanori Sawamura, Tomoyuki Taguchi, Masashi Ikuno, Seiji Kaji, Yosuke Taruno, Shuichi Matsuzawa, Hodaka Yamakado, Ryosuke Takahashi

Movement disorders : official journal of the Movement Disorder Society, Apr 4, 2021
Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice

Shinya Okuda, Norihito Uemura, Masanori Sawamura, Tomoyuki Taguchi, Masashi Ikuno, Maiko T. Uemura, Hodaka Yamakado, Ryosuke Takahashi

Apr 2, 2021
α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.

Norihito Uemura, Jun Ueda, Toru Yoshihara, Masashi Ikuno, Maiko T Uemura, Hodaka Yamakado, Masahide Asano, John Q Trojanowski, Ryosuke Takahashi

Movement disorders : official journal of the Movement Disorder Society, Feb 6, 2021
α-Synuclein Propagation Mouse Models of Parkinson's Disease.

Norihito Uemura, Jun Ueda, Shinya Okuda, Masanori Sawamura, Ryosuke Takahashi

Methods in molecular biology (Clifton, N.J.), 2322 119-130, 2021
Nose-to-Brain薬物送達研究の最新知見とDDS 異常タンパク質の嗅覚系脳内伝播経路と非ヒト霊長類モデル

澤村正典, 尾上浩隆, 伊佐かおる, 上村紀仁, 伊佐正, 高橋良輔

日本DDS学会学術集会プログラム予稿集, 36回 82-82, Aug, 2020
Cell-to-Cell Transmission of Tau and α-Synuclein

Norihito Uemura, Maiko T. Uemura, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski

Trends in Molecular Medicine, May, 2020 Peer-reviewed
Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol.

Hisako Akiyama, Mitsuko Ide, Yasuko Nagatsuka, Tomoko Sayano, Etsuro Nakanishi, Norihito Uemura, Kohei Yuyama, Yoshiki Yamaguchi, Hiroyuki Kamiguchi, Ryosuke Takahashi …

The Journal of biological chemistry, 295(16) 5257-5277, Apr 17, 2020
α-Synuclein BAC transgenic mice exhibited RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.

Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J …

Brain : a journal of neurology, Dec, 2019 Peer-reviewed

Misc.

125

グルコシルセラミド分解酵素による新規脳内ステロール代謝物・ステロール配糖体の代謝制御

秋山央子, 井手三津子, 中西悦郎, 上村紀仁, 山口芳樹, Greimel Peter, 上口裕之, 高橋良輔, 平林義雄

日本生化学会大会プログラム・講演要旨集, 92回 [1T10a-06], Sep, 2019
グルコシルセラミド分解酵素による脳内ステロール配糖体群の代謝制御

秋山央子, 井手三津子, 佐矢野智子, 中西悦郎, 上村紀仁, Greimel Peter, 高橋良輔, 平林義雄

脂質生化学研究, 60 170-171, May, 2018
パーキンソン病リスク遺伝子としてのGBA

上村紀仁

最新医学, 73(4) 586‐592-592, Apr 10, 2018
Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Seiji Kaji, Takakuni Maki, Hisanori Kinoshita, Norihito Uemura, Takashi Ayaki, Yasuhiro Kawamoto, Takahiro Furuta, Makoto Urushitani, Masato Hasegawa, Yusuke Kinoshita …

Stem Cell Reports, 10(2) 356-365, Feb 13, 2018
MPTPパーキンソン病モデルにおけるATP制御薬の発症緩和効果

中野将希, 今村博臣, 笹岡紀男, 山本正道, 上村紀仁, 首藤敏之, 渕上智弘, 高橋良輔, 垣塚彰

日本生体エネルギー研究会討論会講演要旨集, 43rd 46‐47, Dec 5, 2017
PD治療はどこをめざすのか抗体療法と酵素阻害療法

高橋良輔, 山門穂高, 上村紀仁

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 11回 48-48, Oct, 2017
新規compound Xはα-シヌクレイン凝集体誘発ニューロン欠損に対して保護作用を有する(A novel compound X has protective effect against neuronal loss induced by α-synculein aggregation)

澤村正典, 上村紀仁, 高橋良輔

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 11回 68-68, Oct, 2017
αシヌクレイントランスジェニックマウスへのフィブリル脳内接種によるパーキンソン病動物モデル作製

奥田真也, 上村紀仁, 上村麻衣子, 山門穂高, 高橋良輔

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 11th 98-98, Oct, 2017
パーキンソン病の新展開―発症の分子機構と新規治療分子機構解明の新しい展開 GBA遺伝子変異とパーキンソン病

中西悦郎, 上村紀仁

医学のあゆみ, 262(6) 597‐601-601, Aug 5, 2017
パーキンソン病の新展開―発症の分子機構と新規治療分子機構解明の新しい展開 αシヌクレイン凝集・伝播と細胞死

澤村正典, 上村紀仁, 高橋良輔

医学のあゆみ, 262(6) 585‐589-589, Aug 5, 2017
The relationship between the GBA mutations and Parkinson's disease

中西悦郎, 上村紀仁

医学のあゆみ, 262(6) 597-601, Aug 5, 2017
α-Syn aggregation and propagation leading to cell death

澤村正典, 上村紀仁, 高橋良輔

医学のあゆみ, 262(6) 585-589, Aug 5, 2017
Is the GBA2 a new modifier for Gauchers's disease and GBA1-related Parkinson's disease?

E. Nakanishi, N. Uemura, H. Akiyama, M. Kinoshita, H. Yamakado, S. Takeda, Y. Hirabayashi, R. Takahashi

MOVEMENT DISORDERS, 32, Jun, 2017
抗体療法と酵素阻害療法

高橋良輔, 山門穂高, 上村紀仁

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 11th 48, 2017
ATP制御薬による細胞内ATP維持はMPTPパーキンソン病モデルにおいて発症を緩和する

中野将希, 今村博臣, 笹岡紀男, 山本正道, 上村紀仁, 首藤敏之, 首藤敏之, 渕上智弘, 高橋良輔, 垣塚彰

日本生化学会大会(Web), 90th ROMBUNNO.2AT26‐09(2P‐1059) (WEB ONLY), 2017
遺伝子改変とαシヌクレイン接種による新規パーキンソン病モデルマウスの開発

上村紀仁, 生野真嗣, 山門穂高, 高橋良輔

日本生化学会大会(Web), 90th ROMBUNNO.3AW24‐2 (WEB ONLY), 2017
脊髄サルコイドーシスの治療に関する臨床的検討

三橋賢人, 北村彰浩, 小林勝哉, 上村紀仁, 葛谷聡, 山下博史, 澤本伸克, 近藤誉之, 漆谷真, 池田昭夫 …

日本神経学会学術大会プログラム・抄録集, 56(Suppl.) S460-S460, Dec, 2016
基礎から臨床にみる神経細胞の特殊性と普遍性神経型ゴーシェ病モデルメダカは軸索にアルファシヌクレイン蓄積を示す

上村紀仁

日本放射線影響学会大会講演要旨集, 59回 15-15, Oct, 2016
α-synuclein BACトランスジェニックマウスにおいてα-synuclein原線維播種はLewy病理を促進するか(Does inoculation of α-synuclein fibrils promote Lewy-pathology of α-synuclein BAC transgenic mice?)

奥田真也, 生野真嗣, 山門穂高, 上村紀仁, 高橋良輔

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 10回 70-70, Oct, 2016
トランスジェニックモデルにおいてパーキンソン病様症状を内因性α-synucleinは軽減するのか(Dose endogenous alpha-synuclein alleviate parkinsonian symptoms in transgenic models?)

澤村正典, 上村紀仁, 高橋良輔

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 10回 70-70, Oct, 2016

Research Projects

Development of novel mice models replicating Parkinson's disease pathology from its initial lesion

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Uemura Norihito
Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 Mutations

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Takahashi Ryosuke, YAMAKADO Hodaka, UEMURA Norihito, Ikuno Masashi, Nakanishi Etsuro
Genetic research on Parkinson's disease using medaka fish

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Uemura Norihito, KINOSHITA Masato, NAKANISHI Etsuro
Analyzing the pathogenesis of neurodegenerative diseases using medaka with multigene mutations.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Takahashi Ryosuke, UEMURA Norihito

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