2016年4月
Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
JOURNAL OF VETERINARY MEDICAL SCIENCE
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- 巻
- 78
- 号
- 4
- 開始ページ
- 685
- 終了ページ
- 689
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1292/jvms.15-0550
- 出版者・発行元
- JAPAN SOC VET SCI
Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
- リンク情報
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- DOI
- https://doi.org/10.1292/jvms.15-0550
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26616000
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873862
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375336400023&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1292/jvms.15-0550
- ISSN : 0916-7250
- eISSN : 1347-7439
- PubMed ID : 26616000
- PubMed Central 記事ID : PMC4873862
- Web of Science ID : WOS:000375336400023