論文

査読有り 筆頭著者 国際誌
2019年7月11日

External validation of the quick Sequential Organ Failure Assessment score for mortality and bacteraemia risk evaluation in Japanese patients undergoing haemodialysis: a retrospective multicentre cohort study.

BMJ open
  • Hiroki Nishiwaki
  • ,
  • Sho Sasaki
  • ,
  • Takeshi Hasegawa
  • ,
  • Fumihiko Sasai
  • ,
  • Hiroo Kawarazaki
  • ,
  • Shun Minatoguchi
  • ,
  • Daisuke Uchida
  • ,
  • Kenichiro Koitabashi
  • ,
  • Takaya Ozeki
  • ,
  • Fumihiko Koiwa

9
7
開始ページ
e028856
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1136/bmjopen-2018-028856

OBJECTIVES: We aimed to examine the validity of the quick Sequential Organ Failure Assessment (qSOFA) score for mortality and bacteraemia risk assessment in Japanese haemodialysis patients. DESIGN: This is a retrospective multicentre cohort study. SETTING: The six participating hospitals are tertiary-care institutions that receive patients on an emergency basis and provide primary, secondary and tertiary care. The other participating hospital is a secondary-care institution that receives patients on an emergency basis and provides both primary and secondary care. PARTICIPANTS: This study included haemodialysis outpatients admitted for bacteraemia suspicion, who had blood drawn for cultures within 48 hours of their initial admission. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was overall in-hospital mortality. Secondary outcomes included 28-day in-hospital mortality and the incidence of bacteraemia diagnosed based on blood culture findings. The discrimination, calibration and test performance of the qSOFA score were assessed. Missing data were handled using multiple imputation. RESULTS: Among the 507 haemodialysis patients admitted with bacteraemia suspicion between August 2011 and July 2013, the overall in-hospital mortality was 14.6% (74/507), the 28-day in-hospital mortality was 11.1% (56/507) and the incidence of bacteraemia, defined as a positive blood culture, was 13.4% (68/507). For predicting in-hospital mortality among haemodialysis patients, the area under the receiver operating characteristic curve was 0.61 (95% CI 0.56-0.67) for a qSOFA score ≥2. The Hosmer-Lemeshow χ2 statistics for the qSOFA score as a predictor of overall and 28-day in-hospital mortality were 5.72 (p=0.02) and 7.40 (p<0.01), respectively. CONCLUSION: On external validation, the qSOFA score exhibited low diagnostic accuracy and miscalibration for in-hospital mortality and bacteraemia among haemodialysis patients.

リンク情報
DOI
https://doi.org/10.1136/bmjopen-2018-028856
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31300504
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629386
ID情報
  • DOI : 10.1136/bmjopen-2018-028856
  • PubMed ID : 31300504
  • PubMed Central 記事ID : PMC6629386

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