論文

査読有り
2018年8月1日

Usefulness of BCOR gene mutation as a prognostic factor in acute myeloid leukemia with intermediate cytogenetic prognosis

Genes Chromosomes and Cancer
  • Kazuki Terada
  • ,
  • Hiroki Yamaguchi
  • ,
  • Toshimitsu Ueki
  • ,
  • Kensuke Usuki
  • ,
  • Yutaka Kobayashi
  • ,
  • Kenji Tajika
  • ,
  • Seiji Gomi
  • ,
  • Saiko Kurosawa
  • ,
  • Riho Saito
  • ,
  • Yutaka Furuta
  • ,
  • Keiki Miyadera
  • ,
  • Taichiro Tokura
  • ,
  • Atsushi Marumo
  • ,
  • Ikuko Omori
  • ,
  • Masahiro Sakaguchi
  • ,
  • Yusuke Fujiwara
  • ,
  • Shunsuke Yui
  • ,
  • Takeshi Ryotokuji
  • ,
  • Kunihito Arai
  • ,
  • Tomoaki Kitano
  • ,
  • Satoshi Wakita
  • ,
  • Takahiro Fukuda
  • ,
  • Koiti Inokuchi

57
8
開始ページ
401
終了ページ
408
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/gcc.22542
出版者・発行元
Blackwell Publishing Inc.

BCOR gene is a transcription regulatory factor that plays an essential role in normal hematopoiesis. The wider introduction of next-generation sequencing technology has led to reports in recent years of mutations in the BCOR gene in acute myeloid leukemia (AML), but the related clinical characteristics and prognosis are not sufficiently understood. We investigated the clinical characteristics and prognosis of 377 de novo AML cases with BCOR or BCORL1 mutation. BCOR or BCORL1 gene mutations were found in 28 cases (7.4%). Among cases aged 65 years or below that were also FLT3-ITD-negative and in the intermediate cytogenetic prognosis group, BCOR or BCORL1 gene mutations were observed in 11% of cases (12 of 111 cases), and this group had significantly lower 5-year overall survival (OS) (13.6% vs. 55.0%, P = 0.0021) and relapse-free survival (RFS) (14.3% vs. 44.5%, P = 0.0168) compared to cases without BCOR or BCORL1 gene mutations. Multivariate analysis demonstrated that BCOR mutations were an independent unfavorable prognostic factor (P = 0.0038, P = 0.0463) for both OS and RFS. In cases of AML that are FLT3-ITD-negative, aged 65 years or below, and in the intermediate cytogenetic prognosis group, which are considered to have relatively favorable prognosis, BCOR gene mutations appear to be an important prognostic factor.

リンク情報
DOI
https://doi.org/10.1002/gcc.22542
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29663558

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