KOSUKE YOSHIHARA

Profile Information

Affiliation: Professor, Graduate School of Medical and Dental Sciences, Niigata University

Degree: 博士号(新潟大学大学院医歯学総合研究科)

Researcher number: 40547535
J-GLOBAL ID: 201801018492003420
researchmap Member ID: B000302039

Research Interests

Research Areas

Research History

Sep, 2022 - Present

Professor, Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
Jul, 2021 - Aug, 2022

Associate Professor, Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
Feb, 2021 - Aug, 2022

Associate Professor, Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
Oct, 2016 - Aug, 2022

Research Associate Professor, Institute for Research Promotion, Niigata University
Jul, 2014 - Jan, 2021

Assistant professor, Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical
Jan, 2012 - Jun, 2014

Postdoctoral fellow, Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center
Apr, 2009 - Dec, 2011

Assistant professor, Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
May, 2003 - Mar, 2006

Department of Obstetrics and Gynecology, Niigata University School of Medicine

Education

Apr, 2006 - Mar, 2009

Niigata University Graduate School of Medical and Dental Sciences
Apr, 1997 - Mar, 2003

Niigata University School of Medicine

Committee Memberships

Dec, 2020 - Present

子宮頸癌治療ガイドライン委員, 日本婦人科腫瘍学会
Mar, 2020 - Present

ガイドライン委員, 日本遺伝性乳癌卵巣癌総合診療制度機構
Dec, 2017 - Present

代議員, 日本婦人科腫瘍学会
Oct, 2017 - Mar, 2020

がんゲノム医療ネットワーキンググループ, 日本癌学会・日本臨床腫瘍学会・日本癌治療学会３学会合同ゲノム医療推進タスクフォース

Awards

Jun, 2016

Yujin Memorial Research Award, Yujin Society

Kosuke Yoshihara

Major Papers

213

Proposing a molecular classification associated with hypercoagulation in ovarian clear cell carcinoma.

Ryo Tamura, Kosuke Yoshihara, Koji Matsuo, Nozomi Yachida, Ai Miyoshi, Kotaro Takahashi, Kentaro Sugino, Manako Yamaguchi, Yutaro Mori, Kazuaki Suda …

Gynecologic oncology, 163(2) 327-333, Aug 24, 2021
Biological significance of KRAS mutant allele expression in ovarian endometriosis.

Nozomi Yachida, Kosuke Yoshihara, Kazuaki Suda, Hirofumi Nakaoka, Haruka Ueda, Kentaro Sugino, Manako Yamaguchi, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura …

Cancer science, 112(5) 2020-2032, May, 2021
Three-dimensional understanding of the morphological complexity of the human uterine endometrium.

Manako Yamaguchi, Kosuke Yoshihara, Kazuaki Suda, Hirofumi Nakaoka, Nozomi Yachida, Haruka Ueda, Kentaro Sugino, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura …

iScience, 24(4) 102258-102258, Apr 23, 2021
Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis.

Kazuaki Suda, Luis Antonio Cruz Diaz, Kosuke Yoshihara, Hirofumi Nakaoka, Nozomi Yachida, Teiichi Motoyama, Ituro Inoue, Takayuki Enomoto

Cancer science, 111(8) 3000-3009, Aug, 2020
XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary.

Ryo Tamura, Kosuke Yoshihara, Hirofumi Nakaoka, Nozomi Yachida, Manako Yamaguchi, Kazuaki Suda, Tatsuya Ishiguro, Koji Nishino, Hiroshi Ichikawa, Keiichi Homma …

Oncogene, 39(17) 3541-3554, Mar 2, 2020 Peer-reviewed
Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium.

Suda K, Nakaoka H, Yoshihara K, Ishiguro T, Adachi S, Kase H, Motoyama T, Inoue I, Enomoto T

Human reproduction (Oxford, England), 34(10) 1899-1905, Oct, 2019 Peer-reviewed
The first Japanese nationwide multicenter study of BRCA mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of BRCA (CHARLOTTE).

Enomoto T, Aoki D, Hattori K, Jinushi M, Kigawa J, Takeshima N, Tsuda H, Watanabe Y, Yoshihara K, Sugiyama T

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 29(6) 1043-1049, Jul, 2019 Peer-reviewed
Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium.

Kazuaki Suda, Hirofumi Nakaoka, Kosuke Yoshihara, Tatsuya Ishiguro, Ryo Tamura, Yutaro Mori, Kaoru Yamawaki, Sosuke Adachi, Tomoko Takahashi, Hiroaki Kase …

Cell reports, 24(7) 1777-1789, Aug 14, 2018 Peer-reviewed
Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions.

Ryo Tamura, Kosuke Yoshihara, Tetsuya Saito, Ryosuke Ishimura, Juan Emmanuel Martínez-Ledesma, Hu Xin, Tatsuya Ishiguro, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda …

Oncogenesis, 7(1) 4-4, Jan 23, 2018 Peer-reviewed
TumorFusions: An integrative resource for cancer-associated transcript fusions

Xin Hu, Qianghu Wang, Ming Tang, Floris Barthel, Samirkumar Amin, Kosuke Yoshihara, Frederick M Lang, Emmanuel Martinez-Ledesma, Soo Hyun Lee, Siyuan Zheng …

Nucleic Acids Research, 46(1) D1144-D1149, Jan 1, 2018 Peer-reviewed
The landscape and therapeutic relevance of cancer-associated transcript fusions

K. Yoshihara, Q. Wang, W. Torres-Garcia, S. Zheng, R. Vegesna, H. Kim, R. G. W. Verhaak

ONCOGENE, 34(37) 4845-4854, Sep, 2015 Peer-reviewed
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

Daniel J. Brat, Roel G. W. Verhaak, Kenneth D. Al-dape, W. K. Alfred Yung, Sofie R. Salama, Lee A. D. Cooper, Esther Rheinbay, C. Ryan Miller, Mark Vitucci, Olena Morozova …

NEW ENGLAND JOURNAL OF MEDICINE, 372(26) 2481-2498, Jun, 2015 Peer-reviewed
Inferring tumour purity and stromal and immune cell admixture from expression data

Kosuke Yoshihara, Maria Shahmoradgoli, Emmanuel Martinez, Rahulsimham Vegesna, Hoon Kim, Wandaliz Torres-Garcia, Victor Trevino, Hui Shen, Peter W. Laird, Douglas A. Levine …

NATURE COMMUNICATIONS, 4 2612, Oct, 2013 Peer-reviewed
High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway

Kosuke Yoshihara, Tatsuhiko Tsunoda, Daichi Shigemizu, Hiroyuki Fujiwara, Masayuki Hatae, Hisaya Fujiwara, Hideaki Masuzaki, Hidetaka Katabuchi, Yosuke Kawakami, Aikou Okamoto …

CLINICAL CANCER RESEARCH, 18(5) 1374-1385, Mar, 2012 Peer-reviewed

Misc.

【婦人科がん機能温存治療のすべて】子宮頸がん広汎子宮頸部摘出術

吉原弘祐, 榎本隆之

産科と婦人科, 88(7) 824-828, Jul, 2021
【ゲノム時代の生殖内分泌学】ゲノムと子宮内膜症

吉原弘祐, 榎本隆之

HORMONE FRONTIER IN GYNECOLOGY, 28(2) 111-114, Jun, 2021
【卵巣癌におけるHRDとPARP阻害薬の効果】卵巣癌の臨床像とHRD

吉原弘祐, 榎本隆之

産婦人科の実際, 70(5) 495-499, May, 2021
Identification of cellular networks for chemoresistance of ovarian clear cell cancers through single nucleus analysis.

Yutaro Mori, Kaoru Yamawaki, Tatsuya Ishiguro, Kosuke Yoshihara, Yusuke Kanda, Daisuke Shiokawa, Takayuki Enomoto, Koji Okamoto

CANCER SCIENCE, 112 375-375, Feb, 2021
Current status of genomic profiling using cancer gene panel testing in Niigata University Medical & Dental Hospital

中野麻恵, 島田能史, 吉原弘祐, 西野幸治, 関根正幸, 齋木琢郎, 松本吉史, 西條康夫, 棗田学, 今井千速 …

日本臨床腫瘍学会学術集会(CD-ROM), 18th, 2021
【一気にやって来た!産婦人科におけるゲノム医療時代】ゲノムに基づく卵巣がんにおける治療法の選別

吉原弘祐

HORMONE FRONTIER IN GYNECOLOGY, 27(4) 263-266, Dec, 2020
ゲノムからみた子宮内膜症

吉原弘祐

日本エンドメトリオーシス学会会誌, 41 45-49, Jul, 2020
卵巣癌の統合ゲノム解析

吉原弘祐

日本婦人科病理学会誌, 10(1) 17-20, Feb, 2020
卵巣癌ゲノムの脆弱性を標的とした新規治療法の開発

吉原弘祐

上原記念生命科学財団研究報告集, 33 1-4, Dec, 2019
ゲノム研究に基づく婦人科がんの発生・進展機構の解明オミックスデータ解析から婦人科悪性腫瘍の発生を探る

吉原弘祐

日本産科婦人科学会雑誌, 71(9) 1741-1750, Sep, 2019
腹腔鏡による迅速な診断が可能であった悪性リンパ腫の一例

西野幸治, 安達聡介, 明石英彦, 工藤梨沙, 茅原誠, 石黒竜也, 吉原弘祐, 磯部真倫, 小林暁子, 西川伸道 …

日本産科婦人科内視鏡学会雑誌, 34(Suppl.I) 202-202, Aug, 2018
機能性子宮体部を持つ先天性腟・頸管欠損症に対する腹腔鏡下広汎頸部摘出術を応用した腹腔鏡下形成手術

小林暁子, 磯部真倫, 上田遥香, 工藤梨沙, 石黒竜也, 安達聡介, 吉原弘祐, 西野幸治, 西川伸道, 関根正幸 …

日本産科婦人科内視鏡学会雑誌, 34(Suppl.I) 399-399, Aug, 2018
女性の家族性がん新潟県におけるHBOC診療体制の確立に向けての取り組み

西野幸治, 須田一暁, 安達聡介, 吉原弘祐, 関根正幸, 榎本隆之, 五十嵐真由子, 土田純子, 中島真人, 永橋昌幸 …

人間ドック, 33(2) 232-232, Aug, 2018
新潟県におけるHBOC診療の取り組み

西野幸治, 須田一暁, 安達聡介, 吉原弘祐, 関根正幸, 榎本隆之, 菊池朗

日本産科婦人科学会雑誌, 70(2) 685-685, Feb, 2018
In vivo dropout screens identified new drug targets for epithelial ovarian cancer

Michiko Kodama, Takahiro Kodama, Kosuke Yoshihara, Kae Hashimoto, Seiji Mabuchi, Kenjiro Sawada, Tadashi Kimura

CANCER SCIENCE, 109 565-565, Jan, 2018
SOX2は子宮体がんの細胞増殖と細胞周期制御において重要である

山脇芳, 石黒竜也, 森裕太郎, 吉原弘祐, 樋口雅也, 藤井雅寛, 岡本康司, 榎本隆之

日本癌学会総会記事, 76回 J-1100, Sep, 2017
深化 TLHこんな時どうする教育、普及する側から見たTLH難症例への対応

磯部真倫, 安達聡介, 吉原弘祐, 西野幸治, 西川伸道, 関根正幸, 榎本隆之

日本産科婦人科内視鏡学会雑誌, 33(Suppl.I) 358-358, Aug, 2017
当科で経験した腹腔鏡手術中における器具破損・紛失症例について

安達聡介, 磯部真倫, 上田遥香, 工藤梨沙, 茅原誠, 石黒竜也, 吉原弘祐, 小林暁子, 西野幸治, 西川伸道 …

日本産科婦人科内視鏡学会雑誌, 33(Suppl.I) 1153-1153, Aug, 2017
癌性腹膜炎との鑑別に腹腔鏡下生検が有用であった結核性腹膜炎の2例

上田遥香, 工藤梨沙, 茅原誠, 石黒竜也, 安達聡介, 郷戸千賀子, 吉原弘祐, 磯部真倫, 小林暁子, 西野幸治 …

日本産科婦人科内視鏡学会雑誌, 33(Suppl.I) 1460-1460, Aug, 2017
当院における前回帝王切開症例の膀胱挙上、癒着に対する剥離の工夫

小林暁子, 磯部真倫, 茅原誠, 石黒竜也, 安達聡介, 吉原弘祐, 西野幸治, 西川伸道, 関根正幸, 榎本隆之

日本産科婦人科内視鏡学会雑誌, 33(Suppl.I) 1501-1501, Aug, 2017

Teaching Experience

Professional Memberships

Research Projects

Gene-environment interactions inducing spatial expansion of mutant clones in human normal tissues

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2027
Identification of the significance of cancer-associated gene mutations in normal endometrium

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Elucidation of pathogenesis of endometriosis and endometriosis-associated ovarian cancer based on genomic analyses for normal endometrium

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
単一細胞シークエンスを用いた卵巣類内膜癌の発症機序の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

安達聡介, 吉原弘祐, 田村亮
Identification of pathogenesis of ovarian clear cell carcinoma by topographic single cell sequencing

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Enomoto Takayuki
New metastatic pathway via mesenteric lymph node involvement in ovarian cancer liver metastasis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Nakano Masato
Elucidation of the pathogenesis of endometriosis based on the integrated OMICS data analyses

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Yoshihara Kosuke
Identification of the pathogenesis from the origin to uterine carcinosarcoma based on evolutional theory

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Enomoto Takayuki
Identification of genomic linkage from ovarian endometriosis to endometrioid carcinoma based on sequential OMICS data analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Kashima Katsunori
Genetic analysis of 19 susceptibility genes including BRCA1/2 genes in ovarian cancer

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Sekine Masayuki
Identification of the pathogenesis of ovarian cancer based on fusion gene profile

Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

KOSUKE YOSHIHARA
Clarification of molecular biological feature of Mullerian endometrioid adenocarcinoma and establishment of differentiation of its origin

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

YAMAGUCHI Masayuki
Elucidating the mechanism of resistance to chemotherapy in gynecologic cancer based on intratumor heterogeneity

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Enomoto Takayuki
Significance of copy-neutral LOH in epithelial ovarian cancer

Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2011 - Dec, 2011

KOSUKE YOSHIHARA
Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

TANAKA Kenichi, YAHATA Tetsuro, YOSHIHARA Kousuke, SEKINE Masayuki

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Major Papers

Misc.

Teaching Experience

Professional Memberships

Research Projects

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