2014年6月
ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children
BRITISH JOURNAL OF HAEMATOLOGY
- 巻
- 165
- 号
- 6
- 開始ページ
- 836
- 終了ページ
- 841
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/bjh.12834
- 出版者・発行元
- WILEY-BLACKWELL
We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.
- リンク情報
- ID情報
-
- DOI : 10.1111/bjh.12834
- ISSN : 0007-1048
- eISSN : 1365-2141
- PubMed ID : 24628626
- Web of Science ID : WOS:000337520600013