2019年
A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops.
F1000Research
- ,
- ,
- 巻
- 8
- 号
- 開始ページ
- 499
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.12688/f1000research.18158.1
Since Ronald Konopka and Seymour Benzer's discovery of the gene Period in the 1970s, the circadian rhythm field has diligently investigated regulatory mechanisms and intracellular transcriptional and translation feedback loops involving Period, and these investigations culminated in a 2017 Nobel Prize in Physiology or Medicine for Michael W. Young, Michael Rosbash, and Jeffrey C. Hall. Although research on 24-hour behavior rhythms started with Period, a series of discoveries in the past decade have shown us that post-transcriptional regulation and protein modification, such as phosphorylation and oxidation, are alternatives ways to building a ticking clock.
- リンク情報
- ID情報
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- DOI : 10.12688/f1000research.18158.1
- PubMed ID : 31031966
- PubMed Central 記事ID : PMC6468715