The aims of the present study were to identify the differences between two mouse lines (high (H)- and low (L)-oxygen consumption) in terms of mitochondrial respiratory activity when GMP (glutamate, malate, and pyruvate) and succinic acid are used as substrates and to examine the relationship between mitochondrial respiration activity and feed efficiency in both lines. The average daily feed intake, feed conversion ratio (FCR), and residual feed intake (RFI) were significantly higher in the H than the L line. The correlation between FCR and RFI was significant (r = 0.60, p < 0.05). RFI was effective as an indicator of feed efficiency. When succinic acid was used as a substrate, mitochondrial respiration states 2-4, ACR, and proton leak were significantly higher in the H than the L line. When GMP was used as a substrate, respiration states 3 and 4 in the H line were significantly higher than those in the L line, and there were significant positive correlations between FCR and RFI and mitochondrial respiration states 2-4. The results indicated that selection for high or low OC changed the basal metabolic rates estimated from liver mitochondrial respiration activity and feed efficiency.

本研究の目的は、GMP（グルタミン酸、リンゴ酸、ピルビン酸）とコハク酸を基質とした場合のミトコンドリア呼吸活性について、2つのマウス系統（高（H）酸素消費量と低（L）酸素消費量）の違いを明らかにし、両系統におけるミトコンドリア呼吸活性と飼料効率の関係を調べることである。1日の平均飼料摂取量，飼料要求率（FCR），残余飼料摂取量（RFI）は，H系統がL系統よりも有意に高かった。FCR と RFI の間には有意な相関関係が見られた（r = 0.60, p < 0.05）。RFIは飼料効率の指標として有効であった。コハク酸を基質とした場合、ミトコンドリア呼吸状態2-4、ACR、プロトンリークはL系統よりもH系統の方が有意に高かった。GMPを基質とした場合、H系統の呼吸状態3および4はL系統よりも有意に高く、FCRおよびRFIとミトコンドリアの呼吸状態2～4の間には有意な正の相関が見られた。この結果から、OCの高いもの、低いものを選択すると、肝臓のミトコンドリア呼吸活性と飼料効率から推定される基礎代謝量が変化することがわかった。

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