1994年
Enzymatic asymmetric synthesis of α-methyl arylalkylamines and α-methyl arylalkylalcohols by arylalkyl acylamidases
Bioorganic and Medicinal Chemistry
- ,
- ,
- 巻
- 2
- 号
- 6
- 開始ページ
- 429
- 終了ページ
- 432
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/0968-0896(94)80011-1
With the novel microbial enzyme, 'arylalkyl acylamidase', optically active α-methyl arylalkylamines and α-methyl arylalkylalcohols have been obtained through enantioselective hydrolysis of their racemic amides and esters. (S)-Enantiomers of 1-methylbenzylamine, 1-methyl-3-phenylpropylamine and 1-methyl-3-phenylpropanol of high optical purity ( >
94 % e.e.) were synthesized with the cells of Nocardia erythropolis IAM 1440 or Cellulomonas fimi AKU 671. (R)-Enantiomer of 1-methyl-3-phenylpropylamine and (S)-enantiomer of 1-methyl-2-phenylpropanol of high optical purity ( >
95 % e.e.) were synthesized with the crude preparation of arylalkyl acylamidase of Pseudomonas putida Sc2 AKU 881. © 1994.
94 % e.e.) were synthesized with the cells of Nocardia erythropolis IAM 1440 or Cellulomonas fimi AKU 671. (R)-Enantiomer of 1-methyl-3-phenylpropylamine and (S)-enantiomer of 1-methyl-2-phenylpropanol of high optical purity ( >
95 % e.e.) were synthesized with the crude preparation of arylalkyl acylamidase of Pseudomonas putida Sc2 AKU 881. © 1994.
- リンク情報
- ID情報
-
- DOI : 10.1016/0968-0896(94)80011-1
- ISSN : 0968-0896
- PubMed ID : 8000864
- SCOPUS ID : 0028458150