Obayashi Norihiko

J-GLOBAL         Last updated: Jul 9, 2019 at 03:02
Obayashi Norihiko
University of Tsukuba
Faculty of Medicine
Job title
Associate Professor

Research Areas


Academic & Professional Experience

Oct 2005
Jun 2008
Assistant Professor, Graduate School of Pharmaceutical Sciences, Hokkaido University
Jun 2008
Mar 2015
Assistant Professor, Graduate School of Life Sciences, Tohoku University
Apr 2015
Associate Professor, Faculty of Medicine, University of Tsukuba


Apr 1993
Mar 1997
Faculty of pharmaceutical sciences, Kyoto university
Apr 1997
Mar 1999
Graduate School of Pharmaceutical Sciences, Kyoto university
Apr 1999
Mar 2002
Graduate School of Pharmaceutical Sciences, Kyoto university

Committee Memberships

Jul 2014
F1000Prime  Associate Faculty member

Published Papers

Takahashi, Toshiki; Minami, Setsuya; Tsuchiya, Yugo; Tajima, Kazu; Sakai, Natsumi; Suga, Kei; Hisanaga, Shin-Ichi; Ohbayashi, Norihiko; Fukuda, Mitsunori; Kawahara, Hiroyuki
EMBO reports   20(4)    Feb 2019   [Refereed]
Rab family small GTPases are master regulators of distinct steps of intracellular vesicle trafficking in eukaryotic cells. GDP-bound cytoplasmic forms of Rab proteins are prone to aggregation due to the exposure of hydrophobic groups but the machi...
Ohbayashi, Norihiko; Fukuda, Mitsunori
Biochemical Society transactions   46(4) 911-917   Jul 2018   [Refereed]
Historically, studies on the maturation and intracellular transport of melanosomes in melanocytes have greatly contributed to elucidating the general mechanisms of intracellular transport in many different types of mammalian cells. During melanoso...
Lin, Yueh-Chien; Chen, Chien-Chin; Chen, Wei-Min; Lu, Kuan-Ying; Shen, Tang-Long; Jou, Yeong-Chin; Shen, Cheng-Huang; Ohbayashi, Norihiko; Kanaho, Yasunori; Huang, Yuan-Li; Lee, Hsinyu
Biochimica et biophysica acta   1863(10) 1305-1315   Jul 2018   [Refereed]
Lysophosphatidic acid (LPA) is a bioactive lipid growth factor which is present in high levels in serum and platelets. LPA binds to its specific G-protein-coupled receptors, including LPA to LPA, thereby regulating various physiological functions,...
Ngo Thai Bich, Van; Hongu, Tsunaki; Miura, Yuki; Katagiri, Naohiro; Ohbayashi, Norihiko; Yamashita-Kanemaru, Yumi; Shibuya, Akira; Funakoshi, Yuji; Kanaho, Yasunori
Scientific reports   8(1) 6283   Apr 2018
Two major phospholipase D (PLD) isozymes in mammals, PLD1 and PLD2, hydrolyze the membrane phospholipid phosphatidylcholine to choline and the lipid messenger phosphatidic acid. Although their roles in cancer cells have been well studied, their fu...
Tsai, Meng-Tsz; Katagiri, Naohiro; Ohbayashi, Norihiko; Iwasaki, Kenichi; Ohkohchi, Nobuhiro; Ding, Shih-Torng; Kanaho, Yasunori; Funakoshi, Yuji
Scientific reports   7(1) 9438   Aug 2017   [Refereed]
HGF and its receptor c-Met are critical molecules in various biological processes. Others and we have previously shown that the small GTPase Arf6 plays a pivotal role in HGF signaling in hepatocytes. However, the molecular mechanism of how Arf6 re...

Books etc

大林, 典彦;金保, 安則 (Part:Contributor, 小胞輸送)
医学書院   Oct 2015   
大林,典彦;福田光則 (Part:Contributor, Rab GTPases and their roles in membrane traffic.)
May 2013   

Conference Activities & Talks

田島佳寿;高橋俊樹;大林, 典彦;福田光則;川原裕之
第41回日本分子生物学会年会   28 Nov 2018   
Functional analysis of a GAP for Rab32/Rab38 that regulates melanogenic enzymes trafficking in melanocytes
Ohbayashi, Norihiko;Marubashi, Soujiro;Fukuda, Mitsunori
The 28th Annual Meeting of Japanese Society for Pigment Cell Research   14 Oct 2018   
Regulation of clathrin-independent cargo trafficking by the ubiquitin-specific protease TRE17/USP6 and the small GTPase Arf6
小倉由希乃;船越, 祐司;大林典彦;金保安則
Tsukuba Global Science Week 2018   20 Sep 2018   
小倉由希乃;船越祐司;大林典彦;金保, 安則
第41回日本分子生物学会年会   29 Nov 2018   
Function of TBC1D24 in clathrin-independent endocytic cargo trafficking.
Nguyen, Nguyen Thi Kim;大林典彦;船越祐司;Kanaho, Yasunori
第91回日本生化学会大会   25 Sep 2018   

Teaching Experience