論文

査読有り
2014年12月

Suprabasin as a novel tumor endothelial cell marker

CANCER SCIENCE
  • Mohammad T. Alam
  • ,
  • Hiroko Nagao-Kitamoto
  • ,
  • Noritaka Ohga
  • ,
  • Kosuke Akiyama
  • ,
  • Nako Maishi
  • ,
  • Taisuke Kawamoto
  • ,
  • Nobuo Shinohara
  • ,
  • Akinobu Taketomi
  • ,
  • Masanobu Shindoh
  • ,
  • Yasuhiro Hida
  • ,
  • Kyoko Hida

105
12
開始ページ
1533
終了ページ
1540
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cas.12549
出版者・発行元
WILEY-BLACKWELL

Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker.


リンク情報
DOI
https://doi.org/10.1111/cas.12549
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25283635
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000346347600003&DestApp=WOS_CPL