2018年6月1日
Copper-Catalyzed Enantioselective Coupling between Allyl-boronates and Phosphates Using a Phenol-Carbene Chiral Ligand: Asymmetric Synthesis of Chiral Branched 1,5-Dienes
Synthesis (Germany)
- ,
- ,
- 巻
- 50
- 号
- 11
- 開始ページ
- 2235
- 終了ページ
- 2246
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1055/s-0036-1591548
- 出版者・発行元
- Georg Thieme Verlag
Details of the Cu-catalyzed enantioselective allyl-allyl coupling reaction between allylboronates and (Z)-allylic phosphates using a new chiral N -heterocyclic carbene (NHC) ligand containing a phenolic hydroxy group are presented. The copper catalysis delivers enantio-enriched chiral 1,5-dienes with a tertiary stereogenic center. Compatibility with various functional groups and the use of earth-abundant and relatively low-toxicity copper as a metal are attractive features of this protocol. The utility of the chiral phenol-NHC ligand for enantioselective copper catalysis with organoboron compounds is demonstrated and enantiodiscrimination models are discussed.
- リンク情報
- ID情報
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- DOI : 10.1055/s-0036-1591548
- ISSN : 1437-210X
- ISSN : 0039-7881
- SCOPUS ID : 85047729450
- Web of Science ID : WOS:000432737800010