2017年2月
Synthesis of alpha-Quaternary Formimides and Aldehydes through Umpolung Asymmetric Copper Catalysis with Isocyanides
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ,
- ,
- 巻
- 139
- 号
- 6
- 開始ページ
- 2184
- 終了ページ
- 2187
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/jacs.6b12881
- 出版者・発行元
- AMER CHEMICAL SOC
A highly regio- and enantioselective copper catalyzed three-component coupling of isocyanides, hydrosilanes, and gamma,gamma-disubstituted allylic phosphates/chlorides to afford chiral alpha-quaternary formimides was enabled by the combined use of our original chiral naphthol-carbene ligand as a functional Cu-supporting ligand and LiOtBu as a stoichiometric Lewis base for Si. The formimides were readily converted to alpha-quaternary aldehydes.
- リンク情報
- ID情報
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- DOI : 10.1021/jacs.6b12881
- ISSN : 0002-7863
- ORCIDのPut Code : 32022017
- Web of Science ID : WOS:000394482200015