Fumiaki Ohtake

Profile Information

Affiliation: Hoshi University

Degree: 博士（農学）(東京大学)

J-GLOBAL ID: 201901001569565202
researchmap Member ID: B000372863

External link: https://polaris.hoshi.ac.jp/kyoshitsu/bunkai/index.html

Research Interests

Research Areas

Life sciences / Functional biochemistry /

Research History

Apr, 2020 - Present

客員研究員, 公益財団法人東京都医学総合研究所
Dec, 2019 - Present

Hoshi University
Apr, 2016 - Nov, 2019

Tokyo Metropolitan Institute of Medical Science

Papers

cIAP1-based degraders induce degradation via branched ubiquitin architectures.

Yoshino Akizuki, Mai Morita, Yuki Mori, Ai Kaiho-Soma, Shivani Dixit, Akinori Endo, Marie Shimogawa, Gosuke Hayashi, Mikihiko Naito, Akimitsu Okamoto, Keiji Tanaka, Yasushi Saeki, Fumiaki Ohtake

Nature chemical biology, Oct 31, 2022 Corresponding author
Quality Control: Maintaining molecular order and preventing cellular chaos.

Sonya Neal, Fumiaki Ohtake, Ana Maria Cuervo, Ramanujan S Hegde, Ursula Jakob, Michael Lazarou, Wendy V Gilbert, Zhijian J Chen, Sharon A Tooze, James E Haber, Kylie J Walters, F Ulrich Hartl

Molecular cell, 82(8) 1390-1397, Apr 21, 2022
Branched ubiquitin code: from basic biology to targeted protein degradation.

Fumiaki Ohtake

Journal of biochemistry, 171(4) 361-366, Mar 31, 2022 Corresponding author
Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation.

Yifan Huang, Hiromasa Yokoe, Ai Kaiho-Soma, Kazunori Takahashi, Yusuke Hirasawa, Hiroshi Morita, Fumiaki Ohtake, Naoki Kanoh

Bioconjugate chemistry, 33(1) 142-151, Jan 19, 2022 Corresponding author
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal dependent and independent pathways.

Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno

Development (Cambridge, England), Sep 14, 2021
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

Ai Kaiho-Soma, Yoshino Akizuki, Katsuhide Igarashi, Akinori Endo, Takuji Shoda, Yasuko Kawase, Yosuke Demizu, Mikihiko Naito, Yasushi Saeki, Keiji Tanaka, Fumiaki Ohtake

Molecular Cell, 81(7) 1411-1424, Feb, 2021 Peer-reviewedCorresponding author
MIND bomb 2 prevents RIPK1 kinase activity-independent apoptosis through ubiquitylation of cFLIPL

Nakabayashi O, Takahashi H, Moriwaki K, Komazawa-Sakon S, Ohtake F, Murai S, Tsuchiya Y, Koyahara Y, Saeki Y, Yoshida Y, Yamazaki S, Tokunaga F, Sawasaki T, Nakano H

Communications Biology, 4(1) 80-80, 2021 Peer-reviewed
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses

Daisuke Oikawa, Yusuke Sato, Fumiaki Ohtake, Keidai Komakura, Kazuki Hanada, Koji Sugawara, Seigo Terawaki, Yukari Mizukami, Hoang T. Phuong, Kiyosei Iio, Shingo Obika, Masaya Fukushi, Takashi Irie, Daisuke Tsuruta, Shinji Sakamoto, Keiji Tanaka, Yasushi Saeki, Shuya Fukai, Fuminori Tokunaga

Communications Biology, 3(1) 163-163, Dec, 2020 Peer-reviewed
cFLIPのユビキチン化による新たなアポトーシス抑制機構の解析

中林修, 高橋宏隆, 村井晋, 大竹史明, 駒澤幸子, 土屋勇一, 佐伯泰, 吉田雪子, 山崎創, 徳永文稔, 森脇健太, 澤崎達也, 中野裕康

日本生化学会大会プログラム・講演要旨集, 93回 [3Z04-364)], Sep, 2020
Mass spectrometry technologies for deciphering the ubiquitin code

Ohtake, F

Trends in Biochemical Sciences, 45 820, Sep, 2020 Peer-reviewedLead authorCorresponding author
The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.

Yasuhiro Fuseya, Hiroaki Fujita, Minsoo Kim, Fumiaki Ohtake, Akira Nishide, Katsuhiro Sasaki, Yasushi Saeki, Keiji Tanaka, Ryosuke Takahashi, Kazuhiro Iwai

Nature cell biology, 22(6) 663-673, Jun, 2020 Peer-reviewed
Stress- and ubiquitylation-dependent phase separation of the proteasome.

Sayaka Yasuda, Hikaru Tsuchiya, Ai Kaiho, Qiang Guo, Ken Ikeuchi, Akinori Endo, Naoko Arai, Fumiaki Ohtake, Shigeo Murata, Toshifumi Inada, Wolfgang Baumeister, Rubén Fernández-Busnadiego, Keiji Tanaka, Yasushi Saeki

Nature, 578(7794) 296-300, Feb 5, 2020 Peer-reviewed
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S

Communications Biology, 3(1) 592, 2020 Peer-reviewed
Methods to measure ubiquitin chain length and linkage.

Ohtake F, Tsuchiya H, Tanaka K, Saeki Y

Methods in enzymology, 618 105-133, 2019 Peer-reviewed
ユビキチン様タンパク質修飾系の多様な機能:分解だけじゃない、真核生物だけじゃないユビキチンの翻訳後修飾コードと細胞内機能

大竹史明, 佐伯泰, 田中啓二

日本生化学会大会プログラム・講演要旨集, 91回 [2S01m-02], Sep, 2018
ユビキチン鎖長決定法の開発

土屋光, 大竹史明, 新井直子, 海保愛, 田中啓二, 佐伯泰

日本生化学会大会プログラム・講演要旨集, 91回 [2T11e-119)], Sep, 2018
K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

Fumiaki Ohtake, Hikaru Tsuchiya, Yasushi Saeki, Keiji Tanaka

Proceedings of the National Academy of Sciences of the United States of America, 115(7) E1401-E1408, Feb 13, 2018 Peer-reviewedLead authorCorresponding author
Ub-ProT reveals global length and composition of protein ubiquitylation in cells.

Hikaru Tsuchiya, Daocharad Burana, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Masayuki Komada, Keiji Tanaka, Yasushi Saeki

Nature communications, 9(1) 524-524, Feb 6, 2018 Peer-reviewed
In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome.

Hikaru Tsuchiya, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Sayaka Yasuda, Keiji Tanaka, Yasushi Saeki

Molecular cell, 66(4) 488-502, May 18, 2017 Peer-reviewed
The emerging complexity of ubiquitin architecture

Fumiaki Ohtake, Hikaru Tsuchiya

JOURNAL OF BIOCHEMISTRY, 161(2) 125-133, Feb, 2017 Peer-reviewedLead authorCorresponding author

Misc.

Ubiquitin biology revealed by proteomics analysis

大竹史明, 遠藤彬則, 土屋光, 佐伯泰

質量分析総合討論会講演要旨集, 68th, 2020
ユビキチン鎖長決定法の開発

土屋光, 大竹史明, 新井直子, 海保愛, 田中啓二, 佐伯泰

日本生化学会大会(Web), 91st, 2018
出芽酵母におけるK48/K63分岐型ポリユビキチン鎖の解析

河野有紗, 河野有紗, 大竹史明, 佐伯泰, 田中啓二

日本生化学会大会(Web), 90th ROMBUNNO.2P‐0166 (WEB ONLY)-0166], Dec, 2017
Roles of ubiquitin chains in activation of NF-κB signaling

大竹史明

臨床免疫・アレルギー科 = Clinical immunology & allergology, 68(5) 569-575, Nov, 2017
UPSの未解決問題に挑むついに明かされるプロテアソーム分解の制御機構

佐伯泰, 土屋光, 大竹史明, 田中啓二

実験医学, 35(16) 2756‐2763-2763, Oct 1, 2017
エピジェネティクス機構を考慮したトキシコゲノミクスの展開炎症応答を制御する新たなユビキチン・シグナル

大竹史明, 田中啓二

The Journal of Toxicological Sciences, 42(Suppl.) S72-S72, Jun, 2017
Quantitative analysis of the ubiquitin signal in NF-κB regulation

OHTAKE Fumiaki, TANAKA Keiji

Annual Meeting of the Japanese Society of Toxicology, 44 S11-3, 2017
Deciphering the Ubiquitin Code: Absolute Quantification of Ubiquitin Chains by Parallel Reaction Monitoring

Saeki Yasushi, Tsuchiya Hikaru, Ohtake Fumiaki, Tanaka Keiji

Abstracts for Annual Meeting of Japanese Proteomics Society, 2016 33-33, 2016

Presentations

Branched ubiquitin chains promote chemically-induced targeted protein degradation,

大竹史明

第44回日本分子生物学会年会 “Breakthroughs in the ubiquitin research accelerated by chemo-technologies”, Dec 2, 2021
標的タンパク質分解薬におけるユビキチン分岐鎖と役割

大竹史明

第40回日本認知症学会学術集会（オンデマンド配信、オンラインシンポジウム）, Nov 26, 2021
化合物による標的タンパク質分解を誘導するユビキチンコード

大竹史明

第94回日本生化学大会シンポジウム「躍動するユビキチンコード研究」, Nov 3, 2021
標的タンパク質分解誘導剤（PROTAC）による分岐型ユビキチン鎖形成

大竹史明

第25回日本がん分子標的治療学会学術集会, May 26, 2021 Invited
Role of ubiquitin chain architecture revealed by chemo-technology

Ohtake F

Sep 15, 2020 Invited
プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー

大竹史明

日本質量分析学会第68回質量分析総合討論会(誌上開催), May, 2020 Invited
質量分析技術とケミカルツールでユビキチン鎖の複雑性に挑む

大竹史明

第4回先端ケミカルバイオロジー研究会, Jun 9, 2019 Invited

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