Fumiaki Ohtake

Profile Information

Affiliation: Hoshi University

Degree: 博士（農学）(東京大学)

J-GLOBAL ID: 201901001569565202
researchmap Member ID: B000372863

External link: https://polaris.hoshi.ac.jp/kyoshitsu/bunkai/index.html

Research Interests

Research Areas

Life sciences / Functional biochemistry /

Research History

Apr, 2020 - Present

客員研究員, 公益財団法人東京都医学総合研究所
Dec, 2019 - Present

Hoshi University
Apr, 2016 - Nov, 2019

Tokyo Metropolitan Institute of Medical Science

Papers

Combinatorial ubiquitin code degrades deubiquitylation-protected substrates.

Mai Morita, Miyu Takao, Honoka Tokuhisa, Ryotaro Chiba, Shota Tomomatsu, Yoshino Akizuki, Takuya Tomita, Akinori Endo, Yasushi Saeki, Yusuke Sato …

Nature communications, 16(1) 2496-2496, Mar 24, 2025
Intrinsic signaling pathways modulate targeted protein degradation.

Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki …

Nature communications, 15(1) 5379-5379, Jul 2, 2024
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome.

Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki …

The Journal of experimental medicine, 221(6), Jun 3, 2024
USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes

Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki …

Journal of Cell Biology, 223(3), Jan 5, 2024
Senescent cells form nuclear foci that contain the 26S proteasome.

Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya …

Cell reports, 112880-112880, Aug 1, 2023
cIAP1-based degraders induce degradation via branched ubiquitin architectures.

Yoshino Akizuki, Mai Morita, Yuki Mori, Ai Kaiho-Soma, Shivani Dixit, Akinori Endo, Marie Shimogawa, Gosuke Hayashi, Mikihiko Naito, Akimitsu Okamoto …

Nature chemical biology, 19(3) 311-322, Oct 31, 2022 Corresponding author
Quality Control: Maintaining molecular order and preventing cellular chaos.

Sonya Neal, Fumiaki Ohtake, Ana Maria Cuervo, Ramanujan S Hegde, Ursula Jakob, Michael Lazarou, Wendy V Gilbert, Zhijian J Chen, Sharon A Tooze, James E Haber …

Molecular cell, 82(8) 1390-1397, Apr 21, 2022
Branched ubiquitin code: from basic biology to targeted protein degradation.

Fumiaki Ohtake

Journal of biochemistry, 171(4) 361-366, Mar 31, 2022 Corresponding author
Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation.

Yifan Huang, Hiromasa Yokoe, Ai Kaiho-Soma, Kazunori Takahashi, Yusuke Hirasawa, Hiroshi Morita, Fumiaki Ohtake, Naoki Kanoh

Bioconjugate chemistry, 33(1) 142-151, Jan 19, 2022 Corresponding author
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal dependent and independent pathways.

Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno

Development (Cambridge, England), Sep 14, 2021
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

Ai Kaiho-Soma, Yoshino Akizuki, Katsuhide Igarashi, Akinori Endo, Takuji Shoda, Yasuko Kawase, Yosuke Demizu, Mikihiko Naito, Yasushi Saeki, Keiji Tanaka …

Molecular Cell, 81(7) 1411-1424, Feb, 2021 Peer-reviewedCorresponding author
MIND bomb 2 prevents RIPK1 kinase activity-independent apoptosis through ubiquitylation of cFLIPL

Nakabayashi O, Takahashi H, Moriwaki K, Komazawa-Sakon S, Ohtake F, Murai S, Tsuchiya Y, Koyahara Y, Saeki Y, Yoshida Y …

Communications Biology, 4(1) 80-80, 2021 Peer-reviewed
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses

Daisuke Oikawa, Yusuke Sato, Fumiaki Ohtake, Keidai Komakura, Kazuki Hanada, Koji Sugawara, Seigo Terawaki, Yukari Mizukami, Hoang T. Phuong, Kiyosei Iio …

Communications Biology, 3(1) 163-163, Dec, 2020 Peer-reviewed
cFLIPのユビキチン化による新たなアポトーシス抑制機構の解析

中林修, 高橋宏隆, 村井晋, 大竹史明, 駒澤幸子, 土屋勇一, 佐伯泰, 吉田雪子, 山崎創, 徳永文稔 …

日本生化学会大会プログラム・講演要旨集, 93回 [3Z04-364)], Sep, 2020
Mass spectrometry technologies for deciphering the ubiquitin code

Ohtake, F

Trends in Biochemical Sciences, 45 820, Sep, 2020 Peer-reviewedLead authorCorresponding author
The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.

Yasuhiro Fuseya, Hiroaki Fujita, Minsoo Kim, Fumiaki Ohtake, Akira Nishide, Katsuhiro Sasaki, Yasushi Saeki, Keiji Tanaka, Ryosuke Takahashi, Kazuhiro Iwai

Nature cell biology, 22(6) 663-673, Jun, 2020 Peer-reviewed
Stress- and ubiquitylation-dependent phase separation of the proteasome.

Sayaka Yasuda, Hikaru Tsuchiya, Ai Kaiho, Qiang Guo, Ken Ikeuchi, Akinori Endo, Naoko Arai, Fumiaki Ohtake, Shigeo Murata, Toshifumi Inada …

Nature, 578(7794) 296-300, Feb 5, 2020 Peer-reviewed
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H …

Communications Biology, 3(1) 592, 2020 Peer-reviewed
Methods to measure ubiquitin chain length and linkage.

Ohtake F, Tsuchiya H, Tanaka K, Saeki Y

Methods in enzymology, 618 105-133, 2019 Peer-reviewed
ユビキチン様タンパク質修飾系の多様な機能:分解だけじゃない、真核生物だけじゃないユビキチンの翻訳後修飾コードと細胞内機能

大竹史明, 佐伯泰, 田中啓二

日本生化学会大会プログラム・講演要旨集, 91回 [2S01m-02], Sep, 2018

Misc.

Ubiquitin biology revealed by proteomics analysis

大竹史明, 遠藤彬則, 土屋光, 佐伯泰

質量分析総合討論会講演要旨集, 68th, 2020
ユビキチン鎖長決定法の開発

土屋光, 大竹史明, 新井直子, 海保愛, 田中啓二, 佐伯泰

日本生化学会大会(Web), 91st, 2018
出芽酵母におけるK48/K63分岐型ポリユビキチン鎖の解析

河野有紗, 河野有紗, 大竹史明, 佐伯泰, 田中啓二

日本生化学会大会(Web), 90th ROMBUNNO.2P‐0166 (WEB ONLY)-0166], Dec, 2017
Roles of ubiquitin chains in activation of NF-κB signaling

大竹史明

臨床免疫・アレルギー科 = Clinical immunology & allergology, 68(5) 569-575, Nov, 2017
UPSの未解決問題に挑むついに明かされるプロテアソーム分解の制御機構

佐伯泰, 土屋光, 大竹史明, 田中啓二

実験医学, 35(16) 2756‐2763-2763, Oct 1, 2017
エピジェネティクス機構を考慮したトキシコゲノミクスの展開炎症応答を制御する新たなユビキチン・シグナル

大竹史明, 田中啓二

The Journal of Toxicological Sciences, 42(Suppl.) S72-S72, Jun, 2017
Quantitative analysis of the ubiquitin signal in NF-κB regulation

OHTAKE Fumiaki, TANAKA Keiji

Annual Meeting of the Japanese Society of Toxicology, 44 S11-3, 2017
Deciphering the Ubiquitin Code: Absolute Quantification of Ubiquitin Chains by Parallel Reaction Monitoring

Saeki Yasushi, Tsuchiya Hikaru, Ohtake Fumiaki, Tanaka Keiji

Abstracts for Annual Meeting of Japanese Proteomics Society, 2016 33-33, 2016

Presentations

Role of the branched ubiquitin chains in targeted protein degradation

Fumiaki Ohtake

Cold Spring Harbor Laboratory Meeting 「Ubiquitins, autophagy and diseases」, Apr 25, 2023 Invited
標的タンパク質分解誘導剤によるネオユビキチンコード形成機構

大竹史明

第95回日本生化学会大会シンポジウム「ユビキチン・プロテアソーム研究のニューフロンティア」, Nov 11, 2022 Invited
Branched ubiquitin chains promote chemically-induced targeted protein degradation,

大竹史明

第44回日本分子生物学会年会 “Breakthroughs in the ubiquitin research accelerated by chemo-technologies”, Dec 2, 2021
標的タンパク質分解薬におけるユビキチン分岐鎖と役割

大竹史明

第40回日本認知症学会学術集会（オンデマンド配信、オンラインシンポジウム）, Nov 26, 2021
化合物による標的タンパク質分解を誘導するユビキチンコード

大竹史明

第94回日本生化学大会シンポジウム「躍動するユビキチンコード研究」, Nov 3, 2021
標的タンパク質分解誘導剤（PROTAC）による分岐型ユビキチン鎖形成

大竹史明

第25回日本がん分子標的治療学会学術集会, May 26, 2021 Invited
Role of ubiquitin chain architecture revealed by chemo-technology

Ohtake F

Sep 15, 2020 Invited
プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー

大竹史明

日本質量分析学会第68回質量分析総合討論会(誌上開催), May, 2020 Invited
質量分析技術とケミカルツールでユビキチン鎖の複雑性に挑む

大竹史明

第4回先端ケミカルバイオロジー研究会, Jun 9, 2019 Invited

Research Projects

Elucidating the role of branched ubiquitin code

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
Decryption of the ubiquitin code by chemo-technologies and advanced proteomics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2023
翻訳後修飾によらないユビキチンの新機能

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2020 - Mar, 2022

大竹史明
Elucidating the role of branched ubiquitin code

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Ohtake Fumiaki
Construction of quantitative reporter system for branched ubiquitin chains

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

OHTAKE Fumiaki
Role of the ubiquitin system in the regulation of gene expression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2012 - Mar, 2017

OHTAKE Fumiaki
蛋白質分解制御による新たなシグナル伝達機構の解明

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2011 - Mar, 2013

大竹史明
Molecular pathways of fat-soluble ligands through the ubiquitin system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2013

OHTAKE Fumiaki
Characterization of the ubiquitin code

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

OHTAKE Fumiaki
脂溶性リガンドを受容するセルセンサーの新たな分子作用機序の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2009 - 2010

大竹史明, 武山健一, 北川浩史
タンパク質分解を介した核内受容体機能と生物学的意義の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2009 - 2010

大竹史明, 北川浩史
Regulation of post-translational modifications through fat-soluble ligands

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

OHTAKE Fumiaki
骨代謝制御因子としての核内ステロイド受容体群の機能

科学研究費助成事業, 基盤研究(A), 日本学術振興会, 2008 - 2010

加藤茂明, 高田伊知郎, 山本陽子, 大竹史明
The role of the nuclear receptors in cancer development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

KATO Shigeaki, TAKEYAMA Ken-ichi, KITAGAWA Hirochika, TAKADA Ichiro, OHTAKE Fumiaki, TAKEYAMA Ken-chi, KITAGAWA Hirochika, OHTAKE Fumiaki
リガンド依存性ユビキチンリガーゼの機能制御機構の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2007 - 2008

大竹史明, 武山健一, 北川浩史

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