Ohuchi Hideyo

Profile Information

Affiliation: -

J-GLOBAL ID: 201101026918230535
researchmap Member ID: B000001704

Research Interests

Research Areas

Major Papers

139

Mammalian type Opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response.

Keita Sato, Takahiro Yamashita, Hideyo Ohuchi

The Journal of biological chemistry, 105020-105020, Jul 7, 2023 Peer-reviewedLast authorCorresponding author
The medaka mutant deficient in eyes shut homolog exhibits opsin transport defects and enhanced autophagy in retinal photoreceptors

Keita Sato, Yang Liu, Takahiro Yamashita, Hideyo Ohuchi

Cell Tissue Res, 391(2) 249-267, Feb, 2023 Peer-reviewedLast authorCorresponding author
Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress–Induced Cell Death

Yuki Kanzaki, Hirofumi Fujita, Keita Sato, Mio Hosokawa, Hiroshi Matsumae, Yuki Morizane, Hideyo Ohuchi

Investigative Opthalmology and Visual Science, 63(12) 29-29, Nov 22, 2022 Peer-reviewedLast authorCorresponding author
The Opsin 3/Teleost multiple tissue opsin system: mRNA localization in the retina and brain of medaka (Oryzias latipes)

Sato K, Nwe Nwe K, Ohuchi H

J Comp Neurol, 529(10) 2484-2516, Jan 11, 2021 Peer-reviewedLast authorCorresponding author
Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung

Munenori Habuta, Akihiro Yasue, Ken-ichi T. Suzuki, Hirofumi Fujita, Keita Sato, Hitomi Kono, Ayuko Takayama, Tetsuya Bando, Satoru Miyaishi, Seiichi Oyadomari …

PLOS ONE, 15(10) e0240333-e0240333, Oct 15, 2020 Peer-reviewedLast authorCorresponding author
KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells

Yuki Kanzaki, Hirofumi Fujita, Keita Sato, Mio Hosokawa, Hiroshi Matsumae, Fumio Shiraga, Yuki Morizane, Hideyo Ohuchi

Investigative Opthalmology & Visual Science, 61(5) 38-38, May 21, 2020 Peer-reviewedLast authorCorresponding author
Localization of the ultraviolet-sensor Opn5m and its effect on myopia-related gene expression in the late-embryonic chick eye.

Kato M, Sato K, Habuta M, Fujita H, Bando T, Morizane Y, Shiraga F, Miyaishi S, Ohuchi H

Biochemistry and biophysics reports, 19 100665-100665, Sep, 2019 Peer-reviewedLast authorCorresponding author
Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor

Keita Sato, Takahiro Yamashita, Hideyo Ohuchi, Atsuko Takeuchi, Hitoshi Gotoh, Katsuhiko Ono, Misao Mizuno, Yasuhisa Mizutani, Sayuri Tomonari, Kazumi Sakai …

Nature Communications, 9(1) 1255, Dec 1, 2018 Peer-reviewed
Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos

Akihiro Yasue, Hitomi Kono, Munenori Habuta, Tetsuya Bando, Keita Sato, Junji Inoue, Seiichi Oyadomari, Sumihare Noji, Eiji Tanaka, Hideyo Ohuchi

Scientific Reports, 7(1) 53, 2017 Peer-reviewedLast authorCorresponding author
Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum

Mutsuko Kato, Takashi Sugiyama, Kazumi Sakai, Takahiro Yamashita, Hirofumi Fujita, Keita Sato, Sayuri Tomonari, Yoshinori Shichida, Hideyo Ohuchi

PLOS ONE, 11(11) e0163925, Nov, 2016 Peer-reviewedLast authorCorresponding author
Evolution of Mammalian Opn5 as a Specialized UV-absorbing Pigment by a Single Amino Acid Mutation

Takahiro Yamashita, Katsuhiko Ono, Hideyo Ohuchi, Akane Yumoto, Hitoshi Gotoh, Sayuri Tomonari, Kazumi Sakai, Hirofumi Fujita, Yasushi Imamoto, Sumihare Noji …

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(7) 3991-4000, Feb, 2014 Peer-reviewedLead author
A Non-Mammalian Type Opsin 5 Functions Dually in the Photoreceptive and Non-Photoreceptive Organs of Birds

Hideyo Ohuchi, Takahiro Yamashita, Sayuri Tomonari, Sari Fujita-Yanagibayashi, Kazumi Sakai, Sumihare Noji, Yoshinori Shichida

PLOS ONE, 7(2) e31534, Feb, 2012 Peer-reviewedLead authorCorresponding author
Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein

Takahiro Yamashita, Hideyo Ohuchi, Sayuri Tomonari, Keiko Ikeda, Kazumi Sakai, Yoshinori Shichida

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(51) 22084-22089, Dec, 2010 Peer-reviewedLead author
Expression patterns of the opsin 5-related genes in the developing chicken retina

Sayuri Tomonari, Kyoichi Migita, Akira Takagi, Sumihare Noji, Hideyo Ohuchi

DEVELOPMENTAL DYNAMICS, 237(7) 1910-1922, Jul, 2008 Peer-reviewedLast authorCorresponding author
A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development

H Tao, M Shimizu, R Kusumoto, K Ono, S Noji, H Ohuchi

DEVELOPMENT, 132(14) 3217-3230, Jul, 2005 Peer-reviewedLast authorCorresponding author
Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands

M Entesarian, H Matsson, J Klar, B Bergendal, L Olson, R Arakaki, Y Hayashi, H Ohuchi, B Falahat, AI Bolstad …

NATURE GENETICS, 37(2) 125-127, Feb, 2005 Peer-reviewed
FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development

H Ohuchi, Y Hori, M Yamasaki, H Harada, K Sekine, S Kato, N Itoh

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 277(3) 643-649, Nov, 2000 Peer-reviewedLead authorCorresponding author
Fgf10 is essential for limb and lung formation

Keisuke Sekine, Hideyo Ohuchi, Masanori Fujiwara, Masahiro Yamasaki, Tatsuya Yoshizawa, Takashi Sato, Naoko Yagishita, Daisuke Matsui, Yoshihiko Koga, Nobuyuki Itoh …

Nature Genetics, 21(1) 138-141, Jan, 1999 Peer-reviewed
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

H. Ohuchi, T. Nakagawa, A. Yamamoto, A. Araga, T. Ohata, Y. Ishimaru, H. Yoshioka, T. Kuwana, T. Nohno, M. Yamasaki …

Development, 124(11) 2235-2244, 1997 Peer-reviewedLead author

Major Misc.

Fibroblast-growth-factor-induced additional limbs in the study of initiation of limb formation, limb identity, myogenesis, and innervation

Hideyo Ohuchi, Sumihare Noji

Cell and Tissue Research, 296(1) 45-56, 1999 Peer-reviewedInvitedLead author
An additional limb can be induced from the flank of the chick embryo by FGF4

Hideyo Ohuchi, Takashi Nakagawa, Masaki Yamauchi, Takeshi Ohata, Hidefumi Yoshioka, Takashi Kuwana, Tatsuo Mima, Takashi Mikawa, Tsutumu Nohno, Sumihare Noji

Biochemical and Biophysical Research Communications, 209(3) 809-816, Apr 26, 1995 Peer-reviewedLead author
Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis

Hideyo Ohuchi, Hidefumi Yoshioka, Akira Tanaka, Yasuhiko Kawakami, Tsutomu Nohno, Sumihare Noji

Biochemical and Biophysical Research Communications, 204(2) 882-888, Oct 31, 1994 Peer-reviewedLead author
Expression patterns of two fibroblast growth factor receptor genes during early chick eye development.

Ohuchi Hideyo, Koyama Eiki, Myokai Fumio, Nohno Tsutomu, Shiraga Fumio, Matsuo Toshihiko, Matsuo Nobuhiko, Taniguchi Shigehiko, Noji Sumihare

Experimental eye research, 58(6) 649-658, Jun, 1994 Peer-reviewedLead author
EXPRESSION PATTERN OF THE ACTIVIN RECEPTOR TYPE-IIA GENE DURING DIFFERENTIATION OF CHICK NEURAL TISSUES, MUSCLE AND SKIN

H OHUCHI, S NOJI, E KOYAMA, F MYOKAI, K NISHIKAWA, T NOHNO, K TASHIRO, K SHIOKAWA, N MATSUO, S TANIGUCHI

FEBS LETTERS, 303(2-3) 185-189, Jun, 1992 Peer-reviewedLead author

Books and Other Publications

光と生命の事典（編集：真嶋哲朗、飯野盛利、七田芳則、藤堂剛）

大内淑代 (Role: Contributor, 脳内光受容体)

朝倉書店, Feb, 2016 (ISBN: 9784254171617)
発生生物学生物はどのように形づくられるか

Lewis Wolpert 著, 大内淑代, 野地澄晴 (Role: Joint translator)

丸善出版, Jul, 2013 (ISBN: 9784621086896)
マウス表現型解析失敗しないステップ・バイ・ステップアプローチ Mouse Phenotypes, A Handbook of Mutation Analysis, by V. E. Papaioannou & R. R. Behringer, CSHL Press

大内淑代, 井関祥子 (Role: Joint translator)

メデイカルサイエンスインターナショナル, 2006

Presentations

涙器の細胞組織学と組織再生治療

大内淑代

第10回日本涙道・涙液学会総会, Jul 9, 2022 Invited
神経、内分泌系に発現する光受容タンパク質の分子組織学的解析

大内淑代, 佐藤恵太

異分野融合による次世代光生物学研究会, Nov 7, 2019 Invited
非視覚性光受容タンパク質の機能解明とモデル動物を用いた眼疾患研究

大内淑代

第22回眼科分子生物学研究会, Mar 11, 2018 Invited
REIC/DKK3 Expression in Mouse Normal Tissues

Hideyo Ohuchi

The 4th Symposium of the East Asian Gene Therapy Innovative Group in Okayama, Jun 21, 2015 Invited

Research Projects

眼球伸長におけるFGF10と紫光Opsin5システムの機能解明

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2024
Subretinal drug administration for refractory retinal disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023
Mechanism of iPS RPE cell injury by external stress

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Kimura Shuhei, Shiraga Fumio, Morizane Yuki, Toshima Shinji, Araki Ryoichi
GENERATION OF LUNG ORGAN FROM EMBRYONIC STEM CELLS VIA BLASTOCYST COMPLEMENTATION IN MIC

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

SAIJO YASUO, SAKIMURA KENJI, OHUCHI HIDEYO
Functional evolution of the gap gene group in early embryogenesis of the insect

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

NOJI Sumihare, OHUCHI Hideyo, MITO Taro
Identification of organ-specific cis-elements for the Fgf10 gene and their utilization for developmental-engineering tools

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

OHUCHI Hideyo, MITO Taro
眼発生システムにおける線維芽細胞増殖因子19の役割の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2004 - 2005

大内淑代
精子核移植法によるトランスジェニックコオロギ作製法の開発

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2002 - 2003

大内淑代, 三戸太郎
網膜発生システムにおけるFGF10シグナルの役割

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2002 - 2003

大内淑代
器官形成におけるFGF10シグナルネットワークの解明

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 2001 - 2001

大内淑代
Study of the roles of the FGF family in organogenesis and regeneration

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

OHUCHI Hideyo, ITOH Nobuyuki
FGF10ノックアウトマウスを用いたFGF10関連器官形成遺伝子の解析

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 2000 - 2000

大内淑代
FGF10機能喪失マウスを用いた新規形態成遺伝子の単離同定

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 1999 - 1999

大内淑代
四肢形態形成におけるFGF10の役割の解明

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1998 - 1999

大内淑代
Elucidation of the role of FGF-10 in white adipose tissue

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1998 - 1999

ITOH Nobuyuki, OZAKI Keiichi, OHUCHI Hideyo
Mechanism of chick Limb pattern formation, as revealed by a new expresison system with GAL4

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1996 - 1997

NOJI Sumihare, OHUCHI Hideyo, YOSHIOKA Hidefumi
レトロウイルスベクターを用いた新しいクローニング法による肢誘導FGFの同定

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1996 - 1996

大内淑代
Development of a method for making a gene expression map of animal embryos

Grants-in-Aid for Scientific Research, Grant-in-Aid for Developmental Scientific Research (B), Japan Society for the Promotion of Science, 1994 - 1995

NOJI Sumihare, OHUCHI Hideyo, YOSHIOKA Hidefumi, OYAMA Akihiro
Male-specific expression of mouse steroid 16alpha-hydroxylase regulated by growth hormone

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1992 - 1994

YOSHIOKA Hidefumi, OHUCHI Hideyo, NOJI Sumihare

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Research Areas

Major Papers

Major Misc.

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