2007年4月
Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development
DEVELOPMENTAL DYNAMICS
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 236
- 号
- 4
- 開始ページ
- 1134
- 終了ページ
- 1143
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/dvdy.21119
- 出版者・発行元
- WILEY-LISS
Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted lysophospholipase D that generates bioactive phospholipids that act on G protein-coupled receptors. Here we show the expression patterns of the ATX gene in mouse and chicken embryos. ATX has a dynamic spatial and temporal expression pattern in both species and the expression domains during neural development are quite distinct from each other. Murine ATX (mATX) is expressed immediately rostral to the midbrain-hindbrain boundary, whereas chicken ATX (cATX) is expressed in the diencephalon and later in the parencephalon-synencephalon boundary. In the neural tube, cATX is expressed in the alar plate in contrast to mATX in the floor plate. ATX is also expressed in the hindbrain and various organ primordia such as face anlagen and skin appendages of the mouse and chicken. These results suggest conserved and non-conserved roles for ATX during neural development and organogenesis in these species.
- リンク情報
- ID情報
-
- DOI : 10.1002/dvdy.21119
- ISSN : 1058-8388
- PubMed ID : 17366625
- Web of Science ID : WOS:000245883700022