2003年3月
Fibroblast growth factor 10 is required for proper development of the mouse whiskers
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 302
- 号
- 3
- 開始ページ
- 562
- 終了ページ
- 567
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0006-291X(03)00183-9
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse. (C) 2003 Elsevier Science (USA). All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/S0006-291X(03)00183-9
- CiNii Articles
- http://ci.nii.ac.jp/naid/80015870323
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/12615071
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000181755100021&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/S0006-291X(03)00183-9
- ISSN : 0006-291X
- CiNii Articles ID : 80015870323
- PubMed ID : 12615071
- Web of Science ID : WOS:000181755100021