2014年
Nutrients, Clock Genes, and Chrononutrition.
Current nutrition reports
- ,
- ,
- 巻
- 3
- 号
- 3
- 開始ページ
- 204
- 終了ページ
- 212
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s13668-014-0082-6
Circadian clocks that comprise clock genes exist throughout the body and control daily physiological events. The central clock that dominates activity rhythms is entrained by light/dark cycles, whereas peripheral clocks regulating local metabolic rhythms are determined by feeding/fasting cycles. Nutrients reset peripheral circadian clocks and the local clock genes control downstream metabolic processes. Metabolic states also affect the clockworks in feedback manners. Because the circadian system organizes whole energy homeostasis, including food intake, fat accumulation, and caloric expenditure, the disruption of circadian clocks leads to metabolic disorders. Recent findings show that time-restricted feeding during the active phase amplifies circadian clocks and improves metabolic disorders induced by a high-fat diet without caloric reduction, whereas unusual/irregular food intake induces various metabolic dysfunctions. Such evidence from nutrition studies that consider circadian system (chrononutrition) has rapidly accumulated. We review molecular relationships between circadian clocks and nutrition as well as recent chrononutrition findings.
- リンク情報
- ID情報
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- DOI : 10.1007/s13668-014-0082-6
- ISSN : 2161-3311
- ORCIDのPut Code : 68073261
- PubMed ID : 25101217
- PubMed Central 記事ID : PMC4118017
- SCOPUS ID : 84918529692