2016年2月
High-Performance Ferrite Nanoparticles through Nonaqueous Redox Phase Tuning
NANO LETTERS
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- 巻
- 16
- 号
- 2
- 開始ページ
- 1345
- 終了ページ
- 1351
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.nanolett.5b04761
- 出版者・発行元
- AMER CHEMICAL SOC
From magnetic resonance imaging to cancer hyperthermia and wireless control of cell signaling, ferrite nanoparticles produced by thermal decomposition methods are ubiquitous across biomedical applications. While well-established synthetic protocols allow for precise control over the size and shape of the magnetic nanoparticles, structural defects within seemingly single-crystalline materials contribute to variability in the reported magnetic properties. We found that stabilization of metastable wustite in commonly used hydrocarbon solvents contributed to significant cation disorder, leading to nanoparticles with poor hyperthermic efficiencies and transverse relaxivities. By introducing aromatic ethers that undergo radical decomposition upon thermolysis, the electrochemical potential of the solvent environment was tuned to favor the ferrimagnetic phase. Structural and magnetic characterization identified hallmark features Of nearly defect-free ferrite nanoparticles that could not be demonstrated through postsynthesis Oxidation with nearly 500% increase in the specific loss powers and transverse relaxivity times compared to similarly sized nanoparticles containing defects. The improved crystallinity of the nanoparticles enabled rapid wireless control of intracellular calcium. Out work demonstrates that redox tuning during solvent thermolysis can generate potent theranostic agents through selective phase control in ferrites and can be extended to other transition metal oxides relevant to memory and electrochemical storage devices.
- リンク情報
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- DOI
- https://doi.org/10.1021/acs.nanolett.5b04761
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000370215200077&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84958211786&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0003-2776-9509
- ID情報
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- DOI : 10.1021/acs.nanolett.5b04761
- ISSN : 1530-6984
- eISSN : 1530-6992
- ORCIDのPut Code : 45515037
- SCOPUS ID : 84958211786
- Web of Science ID : WOS:000370215200077