論文

査読有り
2001年8月

Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain

Neuropsychopharmacology
  • S Abe
  • ,
  • T Suzuki
  • ,
  • T Ito
  • ,
  • M Yamaguchi
  • ,
  • A Baba
  • ,
  • T Hori
  • ,
  • H Kurita
  • ,
  • H Shiraishi
  • ,
  • N Okado

25
2
開始ページ
173
終了ページ
184
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0893-133X(00)00250-5
出版者・発行元
ELSEVIER SCIENCE INC

Recent animal studies regarding phencyclidine (PCP), which induces psychotic symptoms in humans, have suggested that g-roup II metabotropic glutamate receptors (mGluRs) represent a novel target for the treatment of PCP psychosis. In the present study, we used in situ hybridization to investigate the gene expressions of the mGluR 1-5 subtypes following single and repeated administration of PCP in rats. A single administration Of PCP (7.5mg/kg, i.p.,) resulted in a significant decrease in the mGluR5 inRNA expression of group I inGluR in the subcortical regions (thalamus (-15%), central gray (-23%), inferior colliculus (-23%), and nucleus accumbens (-10%)) and hippocampal formation (CA1 (-14%), CA2 (-15%), CA3 (-18%), and dentate gyrus (-18%)). After repeated PCP administration for 14 days,, the mGluR2 inRNA expression of group II inGluR in the anterior cingulate cortex (-23%) and the mGluR4 mRNA expression of group III mGluR in the cortical regions (parietal (-11%), temporal (-13%) and entorhinal cortices (-18%)), the caudate putamen (-12%), thalamus (-17%), and subiculum (-25%) were significantly decreased. These results indicate that PCP affects not only group II mGluR but also group I and III of mGluR, and it is of particular interest that mGluR2 subtype is involved in a development of behavioral abnormality following repeated PCP administration. Single and repeated administrations of PCP independently regulate the expression of mGluR subtypes of mRNA in the brain. [Neuropsychopharmacology 25:173-184,2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

リンク情報
DOI
https://doi.org/10.1016/S0893-133X(00)00250-5
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000170653800003&DestApp=WOS_CPL
共同研究・競争的資金等の研究課題
薬物依存動物モデルにおける脳内アミノ酸受容体の薬理学的分子生物学的研究
ID情報
  • DOI : 10.1016/S0893-133X(00)00250-5
  • ISSN : 0893-133X
  • Web of Science ID : WOS:000170653800003

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