2001年8月
Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain
Neuropsychopharmacology
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- 巻
- 25
- 号
- 2
- 開始ページ
- 173
- 終了ページ
- 184
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0893-133X(00)00250-5
- 出版者・発行元
- ELSEVIER SCIENCE INC
Recent animal studies regarding phencyclidine (PCP), which induces psychotic symptoms in humans, have suggested that g-roup II metabotropic glutamate receptors (mGluRs) represent a novel target for the treatment of PCP psychosis. In the present study, we used in situ hybridization to investigate the gene expressions of the mGluR 1-5 subtypes following single and repeated administration of PCP in rats. A single administration Of PCP (7.5mg/kg, i.p.,) resulted in a significant decrease in the mGluR5 inRNA expression of group I inGluR in the subcortical regions (thalamus (-15%), central gray (-23%), inferior colliculus (-23%), and nucleus accumbens (-10%)) and hippocampal formation (CA1 (-14%), CA2 (-15%), CA3 (-18%), and dentate gyrus (-18%)). After repeated PCP administration for 14 days,, the mGluR2 inRNA expression of group II inGluR in the anterior cingulate cortex (-23%) and the mGluR4 mRNA expression of group III mGluR in the cortical regions (parietal (-11%), temporal (-13%) and entorhinal cortices (-18%)), the caudate putamen (-12%), thalamus (-17%), and subiculum (-25%) were significantly decreased. These results indicate that PCP affects not only group II mGluR but also group I and III of mGluR, and it is of particular interest that mGluR2 subtype is involved in a development of behavioral abnormality following repeated PCP administration. Single and repeated administrations of PCP independently regulate the expression of mGluR subtypes of mRNA in the brain. [Neuropsychopharmacology 25:173-184,2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
- リンク情報
- ID情報
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- DOI : 10.1016/S0893-133X(00)00250-5
- ISSN : 0893-133X
- Web of Science ID : WOS:000170653800003