論文

国際誌
2021年3月1日

Alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects.

Progress in neuro-psychopharmacology & biological psychiatry
  • Kazutaka Ohi
  • ,
  • Kiyotaka Nemoto
  • ,
  • Yuzuru Kataoka
  • ,
  • Shunsuke Sugiyama
  • ,
  • Yukimasa Muto
  • ,
  • Toshiki Shioiri
  • ,
  • Yasuhiro Kawasaki

開始ページ
110291
終了ページ
110291
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.pnpbp.2021.110291

Reduced hippocampal volumes feature prominently in schizophrenia patients (SCZ). Although several studies have investigated hippocampal volume alterations between unaffected first-degree relatives (FR) of SCZ and healthy controls (HC), the results were inconsistent. Furthermore, it remains unclear whether FR have specific alterations in hippocampal subfield volumes. Three-Tesla T1-weighted MP-RAGE brain scans were collected from 347 subjects (138 SCZ, 47 FR and 162 HC) and processed using the hippocampal subfields algorithm in FreeSurfer v6.0. We investigated volumetric differences in the twelve hippocampal subfields bilaterally among SCZ, FR and HC. SCZ displayed bilateral reductions in whole hippocampal volume compared with FR and HC. The hippocampal volumes of FR did not differ from those of HC but exceeded those observed in SCZ. We found volumetric differences in specific hippocampal subfields, including the CA1, hippocampal fissure, presubiculum, molecular layer, fimbria and hippocampal-amygdala transitional area, among diagnostic groups. These alterations arose from differences in the hippocampal subfield volumes between SCZ and the other two diagnostic groups. However, right hippocampal fissure volumes linearly increased among the groups. In contrast, no significant volumetric differences were found in other hippocampal subfields between HC and FR. There were no significant intergroup differences in laterality in any hippocampal subfield volumes and no significant correlations between hippocampal subfield volumes and illness duration, psychiatric symptoms, antipsychotics or premorbid IQ in SCZ. Our findings suggest that volumetric alterations in hippocampal subfields (except the hippocampal fissure) in SCZ could be stable phenomena that are present at illness onset and minimally affected by antipsychotics.

リンク情報
DOI
https://doi.org/10.1016/j.pnpbp.2021.110291
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33662534

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