論文

国際誌
2021年1月

Shared transethnic genetic basis of panic disorder and psychiatric and related intermediate phenotypes.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
  • Kazutaka Ohi
  • ,
  • Takeshi Otowa
  • ,
  • Mihoko Shimada
  • ,
  • Shunsuke Sugiyama
  • ,
  • Yukimasa Muto
  • ,
  • Shunsuke Tanahashi
  • ,
  • Hisanobu Kaiya
  • ,
  • Fumichika Nishimura
  • ,
  • Tsukasa Sasaki
  • ,
  • Hisashi Tanii
  • ,
  • Toshiki Shioiri

42
開始ページ
87
終了ページ
96
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.euroneuro.2020.11.003

Panic disorder (PD), a common anxiety disorder, is modestly heritable. The genetic basis of anxiety disorders overlaps with that of other psychiatric disorders and their intermediate phenotypes in individuals of European ancestry. Here, we investigated the transethnic polygenetic features shared between Japanese PD patients and European patients with psychiatric disorders and their intermediate phenotypes by conducting polygenic risk score (PRS) analyses. Large-scale European genome-wide association study (GWAS) datasets (n = 7,556-1,131,881) for ten psychiatric disorders and seven intermediate phenotypes were utilized as discovery samples. PRSs derived from these GWASs were calculated for Japanese target subjects [718 PD patients and 1,717 healthy controls (HCs)]. The effects of these PRSs from European GWASs on the risk of PD in Japanese patients were investigated. The PRSs from European studies of anxiety disorders were marginally higher in Japanese PD patients than in HCs (p = 0.013). Regarding other psychiatric disorders, the PRSs for depression in European patients were significantly higher in Japanese PD patients than in HCs (p = 2.31×10-4), while the PRSs for attention-deficit/hyperactivity disorder in European patients were nominally lower in Japanese PD patients than in HCs (p = 0.024). Regarding health-related, personality-based and cognitive intermediate phenotypes, the PRSs for loneliness (especially isolation) in European individuals were significantly higher in Japanese PD patients than in HCs (p = 9.02×10-4). Furthermore, Japanese PD patients scored nominally higher than HCs in PRSs for neuroticism in European people (p = 3.37×10-3), while Japanese PD patients scored nominally lower than HCs in PRSs for tiredness (p = 0.025), educational attainment (p = 0.035) and cognitive function (p = 9.63×10-3). Our findings suggest that PD shares transethnic genetic etiologies with other psychiatric disorders and related intermediate phenotypes.

リンク情報
DOI
https://doi.org/10.1016/j.euroneuro.2020.11.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33189524

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