論文

査読有り 国際誌
2018年7月17日

Rotation of stress fibers as a single wheel in migrating fish keratocytes.

Scientific reports
  • Chika Okimura
  • ,
  • Atsushi Taniguchi
  • ,
  • Shigenori Nonaka
  • ,
  • Yoshiaki Iwadate

8
1
開始ページ
10615
終了ページ
10615
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-018-28875-z

Crawling migration plays an essential role in a variety of biological phenomena, including development, wound healing, and immune system function. Keratocytes are wound-healing cells in fish skin. Expansion of the leading edge of keratocytes and retraction of the rear are respectively induced by actin polymerization and contraction of stress fibers in the same way as for other cell types. Interestingly, stress fibers in keratocytes align almost perpendicular to the migration-direction. It seems that in order to efficiently retract the rear, it is better that the stress fibers align parallel to it. From the unique alignment of stress fibers in keratocytes, we speculated that the stress fibers may play a role for migration other than the retraction. Here, we reveal that the stress fibers are stereoscopically arranged so as to surround the cytoplasm in the cell body; we directly show, in sequential three-dimensional recordings, their rolling motion during migration. Removal of the stress fibers decreased migration velocity and induced the collapse of the left-right balance of crawling migration. The rotation of these stress fibers plays the role of a "wheel" in crawling migration of keratocytes.

リンク情報
DOI
https://doi.org/10.1038/s41598-018-28875-z
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30018412
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050267

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