論文

査読有り 国際誌
2016年7月3日

Fast-crawling cell types migrate to avoid the direction of periodic substratum stretching.

Cell adhesion & migration
  • Chika Okimura
  • ,
  • Kazuki Ueda
  • ,
  • Yuichi Sakumura
  • ,
  • Yoshiaki Iwadate

10
4
開始ページ
331
終了ページ
41
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/19336918.2015.1129482

To investigate the relationship between mechanical stimuli from substrata and related cell functions, one of the most useful techniques is the application of mechanical stimuli via periodic stretching of elastic substrata. In response to this stimulus, Dictyostelium discoideum cells migrate in a direction perpendicular to the stretching direction. The origins of directional migration, higher migration velocity in the direction perpendicular to the stretching direction or the higher probability of a switch of migration direction to perpendicular to the stretching direction, however, remain unknown. In this study, we applied periodic stretching stimuli to neutrophil-like differentiated HL-60 cells, which migrate perpendicular to the direction of stretch. Detailed analysis of the trajectories of HL-60 cells and Dictyostelium cells obtained in a previous study revealed that the higher probability of a switch of migration direction to that perpendicular to the direction of stretching was the main cause of such directional migration. This directional migration appears to be a strategy adopted by fast-crawling cells in which they do not migrate faster in the direction they want to go, but migrate to avoid a direction they do not want to go.

リンク情報
DOI
https://doi.org/10.1080/19336918.2015.1129482
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26980079
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986713

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