Makito Oku

Profile Information

Affiliation: Specially Appointed Associate Professor, Research Center for Pre-disease Science, University of Toyama

Degree: Ph. D. in Information Science and Technology(Sep, 2011, The University of Tokyo)

Researcher number: 30633565
ORCID ID: https://orcid.org/0000-0002-0282-2361
J-GLOBAL ID: 201101039854221418
researchmap Member ID: B000002928

External link: https://okumakito.github.io/en/

Research Areas

Informatics / Biological, health, and medical informatics / bioinformatics

Research History

Oct, 2023 - Present

Specially Appointed Associate Professor, Research Center for Pre-disease Science, University of Toyama
Oct, 2017 - Sep, 2023

Specially Appointed Associate Professor, Institute of Natural Medicine, University of Toyama
Nov, 2012 - Sep, 2017

Research Associate, Institute of Industrial Science, The University of Tokyo
Apr, 2012 - Oct, 2012

Project Research Associate, Institute of Industrial Science, The University of Tokyo
Oct, 2011 - Mar, 2012

JSPS Research Fellow (PD), The University of Tokyo
Apr, 2009 - Sep, 2011

JSPS Research Fellow (DC1), The University of Tokyo

Awards

Mar, 2021

山下記念研究賞, フローサイトメトリーデータ解析ための方向制限付きアースムーバー距離の効率的な計算法, 情報処理学会

奥牧人
Apr, 2020

SIGBIO優秀プレゼンテーション賞, フローサイトメトリーデータ解析ための方向制限付きアースムーバー距離の効率的な計算法, 情報処理学会バイオ情報学研究会

奥牧人
Jan, 2019

SIGBIO優秀プレゼンテーション賞, 同期性揺らぎ遺伝子の二つの新規抽出法, 情報処理学会バイオ情報学研究会

奥牧人
Sep, 2013

Best Paper Award, NOLTA

Oku Makito
Mar, 2012

研究科長賞, 東京大学情報理工学系研究科

奥牧人
Oct, 2009

NOLTA 2009 Student Paper Award Silver Prize, A Meso-Scopic Model of the Binding Formation in the Brain, Research Society of Nonlinear Theory and its Applications, IEICE

Makito Oku

Papers

Establishing Monoclonal Gammopathy of Undetermined Significance as an Independent Pre-Disease State of Multiple Myeloma Using Raman Spectroscopy, Dynamical Network Biomarker Theory, and Energy Landscape Analysis

Shota Yonezawa, Takayuki Haruki, Keiichi Koizumi, Akinori Taketani, YUSUKE OSHIMA, Makito Oku, Akinori Wada, Tsutomu Sato, Naoki Masuda, Jun Tahara …

International Journal of Molecular Sciences, Jan 26, 2024
Model-Free Dominant Pole Placement for Restabilizing High-Dimensional Network Systems via Small-Sample-Size Data

Xun Shen, Hampei Sasahara, Masahide Morishita, Jun-Ichi Imura, Makito Oku, Kazuyuki Aihara

IEEE Access, 11 45572-45585, May, 2023 Peer-reviewed
Design of input assignment and feedback gain for re‐stabilizing undirected networks with High‐Dimension Low‐Sample‐Size data

Hitoshi Yasukata, Xun Shen, Hampei Sasahara, Jun‐ichi Imura, Makito Oku, Kazuyuki Aihara

International Journal of Robust and Nonlinear Control, 33(12) 6734-6753, Apr 25, 2023 Peer-reviewed
Estimation of the critical transition probability using quadratic polynomial approximation with skewness-based reject option

Makito Oku

NOLTA, 14(2) 242-253, Apr, 2023 Peer-reviewedLead author
Intestinal epithelial BLT1 promotes mucosal repair

Shusaku Hayashi, Chithra K. Muraleedharan, Makito Oku, Sunil Tomar, Simon P. Hogan, Miguel Quiros, Charles A. Parkos, Asma Nusrat

JCI Insight, 7(23), Dec 8, 2022 Peer-reviewed
Estimation of the critical transition probability using quadratic polynomial approximation with skewness filtering

Makito Oku

Proc. NOLTA'22, 99-102, Dec, 2022 Peer-reviewedLead author
Application of the Dynamical Network Biomarker Theory to Raman Spectra

Takayuki Haruki, Shota Yonezawa, Keiichi Koizumi, Yasuhiko Yoshida, Tomonobu M. Watanabe, Hideaki Fujita, Yusuke Oshima, Makito Oku, Akinori Taketani, Moe Yamazaki …

Biomolecules, 12(12), Nov 22, 2022 Peer-reviewed
Extraction method of synchronously fluctuated genes without using a control group

Makito Oku

IPSJ SIG Technical Report, 2022-BIO-72(3) 1-6, Nov, 2022 Lead author
A major update of KampoDB for better usability

Makito Oku

IPSJ SIG Technical Report, 2022-BIO-69(14) 1-6, Mar, 2022 Lead author
Low-Sample-Size Data-Driven Re-stabilization of Gene Network Systems

Xun Shen, Masahide Morishita, Imura Jun-ichi, Makito Oku, Kazuyuki Aihara

IFAC PAPERSONLINE, 55(25) 241-246, 2022 Peer-reviewed
Parameter adjustment method in two-step extraction of synchronously fluctuated genes

Makito Oku

IPSJ SIG Technical Report, 2021-BIO-65(5) 1-6, Mar, 2021 Lead author
An efficient method for calculating earth mover's distance with direction restriction for flow cytometry data analysis

Makito Oku

IPSJ SIG Technical Report, 2020-BIO-61(8) 1-6, Mar, 2020 Lead author
Application of dynamical network biomarker analysis to dengue fever virus infection data

Kenya Murata, Takayuki Haruki, Yasuhiko Yoshida, Makito Oku, Keiichi Koizumi, Makoto Kadowaki

IPSJ SIG Technical Report, 2020-BIO-61(2) 1-6, Mar, 2020
Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan.

Keiichi Koizumi, Makito Oku, Shusaku Hayashi, Akiko Inujima, Naotoshi Shibahara, Luonan Chen, Yoshiko Igarashi, Kazuyuki Tobe, Shigeru Saito, Makoto Kadowaki …

Evidence-based complementary and alternative medicine : eCAM, 2020 9129134-9129134, 2020 Peer-reviewed
Network analysis of kampo formulas based on crude drug composition and indications

Makito Oku

Traditional & Kampo Medicine, 6(3) 139-147, Dec, 2019 Peer-reviewedLead author
Early detection of a traffic flow breakdown in the freeway based on dynamical network markers

Md Abdus Samad Kamal, Makito Oku, Tomohisa Hayakawa, Jun-ichi Imura, Kazuyuki Aihara

Int. J. ITS Res., 18(3) 422-435, Dec, 2019 Peer-reviewed
An overview of the docking simulation results in KampoDB

Makito Oku

IPSJ SIG Technical Report, 2019-BIO-59(1) 1-6, Sep, 2019 Lead author
Bubbloid algorithm: A simple method for generating bubble-like line drawings

Makito Oku

Proc. IIAI-AAI'19, 954-959, Jul, 2019 Peer-reviewedLead author
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers

Keiichi Koizumi, Makito Oku, Shusaku Hayashi, Akiko Inujima, Naotoshi Shibahara, Luonan Chen, Yoshiko Igarashi, Kazuyuki Tobe, Shigeru Saito, Makoto Kadowaki …

SCIENTIFIC REPORTS, 9 8767, Jun, 2019 Peer-reviewed
Two Novel Methods for Extracting Synchronously Fluctuated Genes

Makito Oku

IPSJ Transactions on Bioinformatics, 12 9-16, Mar, 2019 Peer-reviewedLead author

Misc.

それ、未病じゃないですか？妊婦に見られる未病について

奥牧人

安全衛生のひろば, 64(7) 44-44, Jul, 2023 InvitedLead author
How Online Classes were Introduced to the Medical School Campus of a Regional University

H. Mihara, H. Kishi, Y. Adachi, T. Shimizu, H. Sakai, M. Oku, A. Fujii

Igaku Kyoiku, 51(3) 255-257, Jun, 2020
遺伝子発現量データ解析の基礎

奥牧人

和漢研年報, 44 2-11, Jul, 2018 InvitedLead author
Branching embedding: A heuristic dimensionality reduction algorithm based on hierarchical clustering

Makito Oku

arXiv, 1805.02161, May, 2018 Lead author
和漢薬の科学基盤新たな創薬方法論と疾病治療戦略の創生を目指して数理科学と和漢薬研究からの挑戦「未病」状態の検出から新たな治療戦略の構築へ

奥牧人, 小泉桂一, 林周作, 門脇真, 合原一幸

日本薬学会年会要旨集, 136年会(1) 288-288, Mar, 2016
Complex Life Systems and Big Data Analysis

Kazuyuki Aihara, Yoshito Hirata, Makito Oku

JIKKEN IGAKU, 34(5) 728-732, 2016 Invited
FIRST合原最先端数理モデルプロジェクトの紹介

奥牧人

JSIAM Online Magazine, D1401A, Mar, 2014 InvitedLead author
神経回路と連想記憶

奥牧人

応用数理ハンドブック (日本応用数理学会監修, 薩摩順吉, 大石進一, 杉原正顕編), 110-111, Oct, 2013 InvitedLead author
Chaotic neural networks and beyond

Kazuyuki Aihara, Taiji Yamada, Makito Oku

Chaos, CNN, Memristors and Beyond: A Festschrift for Leon Chua, 259-270, Jan 1, 2013 Invited
Chaos in neurons and its application: Perspective of chaos engineering

Yoshito Hirata, Makito Oku, Kazuyuki Aihara

CHAOS, 22(4) 047511, Dec, 2012 Peer-reviewedInvited
Mathematical Modelling of Complex Systems and Simulation

Gouhei Tanaka, Makito Oku, Kazuyuki Aihara

J. Jpn. Soc. Sim. Tech., 30(4) 236-241, Dec, 2011 Invited
Noise-robust realization of Turing-complete cellular automata by using an array of Hopfield models combined with multilayered perceptrons

Makito Oku, Kazuyuki Aihara

NEUROSCIENCE RESEARCH, 68 E323-E323, 2010
強化学習の数理

奥牧人

社会を変える驚きの数学 (合原一幸編著), 179-183, Jun, 2008 InvitedLead author

Presentations

Identification of gut microbes that prevents metabolic syndrome in healthy Japanese adults

Hisae Honoki, Shiho Fujisaka, Yoshiyuki Watanabe, Makito Oku, Yuki Kondo, Ayumi Nishimura, Tomonobu Kado, Muhammad Bilal, Asako Enkaku, Akiko Takikawa, Daisuke Chujo, Yoshitomo Morinaga, Kazuyuki Tobe

American Diabetes Accosiation 2023
体重が減少して発症する2型糖尿病の特徴：特定健診データを用いて

四方雅隆, 奥牧人, 福原志音, 伊藤遼, 春木孝之, 上田肇一, 木村巌, 寺元剛, 中條大輔, 山上孝司, 永田義毅, 門脇真, 戸邉一之

第66回日本糖尿病学会年次学術集会, May 12, 2023
Estimation of the critical transition probability using quadratic polynomial approximation with skewness filtering

Makito Oku

NOLTA'22, Dec 12, 2022
Extraction method of synchronously fluctuated genes without using a control group

Makito Oku

SIG-BIO, Nov 29, 2022
機械学習による糖尿病発症予測の試み –BMIによるサブグループ化と予測精度–

福原志音, 伊藤遼, 戸邉一之, 奥牧人, 四方雅隆, 春木孝之, 木村巌, 永田義毅, 山上孝司, 上田肇一

第25回情報論的学習理論ワークショップ (IBIS2022), Nov 21, 2022
家庭血圧測定による妊娠高血圧/妊娠高血圧腎症の発症予測

奥牧人

第62回日本臨床化学会年次学術集会, Oct 1, 2022
和漢医薬学総合研究所の漢方関連データベースの紹介

奥牧人

第11回生命医薬情報学連合大会 (IIBMP2022), Sep 13, 2022
Low-sample-size data-driven re-stabilization of gene network systems

X. Shen, M. Morishita, J. Imura, M. Oku, K. Aihara

ROCOND'22, Sep 2, 2022
構成生薬の分量に基づく漢方処方の次元削減分析

奥牧人

第39回和漢医薬学会学術大会, Aug 27, 2022
企業健診における生活習慣を含む食事記録の解析と健診データと腸内細菌叢解析の関係性について

朴木久恵, 藤坂志帆, 今度悠樹, 圓角麻子, 渡邊善之, 瀧川章子, 八木邦公, 中條大輔, 奥牧人, 戸邉一之

第65回日本糖尿病学会年次学術集会, May 12, 2022
富山県民のメタボリック症候群の生活習慣の実態調査における腸内菌叢解析と食事記録解析

朴木久恵, 藤坂志帆, 今度悠樹, 山田眞之介, 横山茉貴, 圓角麻子, 渡邊善之, 瀧川章子, 杉島有希, 八木邦公, 中條大輔, 奥牧人, 戸邉一之

第42回日本肥満学会, Mar 26, 2022
Assessing the impact of major update of KampoDB based on usage statistics

Makito Oku

Mar 26, 2022
A major update of KampoDB for better usability

Makito Oku

SIG-BIO, Mar 11, 2022
企業健診におけるとやまパラドックス問診票の有効性とインスリン関連指数の関係

朴木久恵, 藤坂志帆, 今度悠樹, 篠田千恵, 圓角麻子, 瀧川章子, 八木邦公, 中條大輔, 奥牧人, 戸邉一之

第75回富山県医学会, Dec 5, 2021
Prediction of hypertensive disorders of pregnancy based on home blood pressure monitoring

S. Ohno, H. Metoki, M. Oku, N. Iwama, A. Shiozaki, A. Nakashima, S. Saito

ISSHP'21, Sep 15, 2021
Parameter adjustment method in two-step extraction of synchronously fluctuated genes

Makito Oku

SIG-BIO, Mar 11, 2021
Estimation of the critical transition probability using quadratic polynomial approximation

Makito Oku

Workshop on Critical Transitions in Complex Systems 2020, Jul 31, 2020
Integrated cluster analysis of bioassay data registered in traditional medical and pharmaceutical database

Makito Oku

The 140th Annual Meeting of the Pharmaceutical Society of Japan, Mar 26, 2020
An efficient method for calculating earth mover's distance with direction restriction for flow cytometry data analysis

Makito Oku

SIG-BIO, Mar 13, 2020
Application of dynamical network biomarker analysis to dengue fever virus infection data

Kenya Murata, Takayuki Haruki, Yasuhiko Yoshida, Makito Oku, Keiichi Koizumi, Makoto Kadowaki

SIG-BIO, Mar 12, 2020

Professional Memberships

Research Projects

漢方医薬学と複雑系数理科学の挑戦～未病の検出から始まる新たな医療戦略の構築へ～

科研費基盤研究(B), Jul, 2017 - Mar, 2021

小泉桂一
生命病態システムの数理モデリングとその個別化医療への応用のための数理的基盤の確立

科研費基盤研究(S), May, 2015 - Mar, 2020

合原一幸
認識系と意志決定系を統合した脳型情報処理モデルの基礎研究

科研費研究活動スタート支援, Aug, 2012 - Mar, 2014

奥牧人
中間的スケールにおける脳情報処理の一般ネットワーク数理モデルの構築及びその解析

科研費特別研究員奨励費, 2009 - Mar, 2012

奥牧人

Education

Oct, 2008 - Sep, 2011

Doctoral Course, Department of Mathematical Informatics, Graduate School of Information Science and Technology, The University of Tokyo
Oct, 2006 - Sep, 2008

Mater Course, Department of Mathematical Informatics, Graduate School of Information Science and Technology, The University of Tokyo

Industrial Property Rights

特開2022-190813 妊娠高血圧または妊娠高血圧腎症の発症予測方法、発症予測プログラムおよび発症予測装置

齋藤滋, 大野駿太郎, 奥牧人, 目時弘仁
特開2015-141541 画像認識装置、画像認識方法、および、プログラム

合原一幸, 鈴木秀幸, 牧野貴樹, 奥牧人
特開2015-095042 画像認識装置、画像認識方法、および、プログラム

合原一幸, 牧野貴樹, 奥牧人
特開2015-095041 画像認識装置、画像認識方法、および、プログラム

合原一幸, 牧野貴樹, 奥牧人

Profile Information

Research Areas

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Awards

Papers

Misc.

Presentations

Professional Memberships

Research Projects

Education

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