Naoki Okumura

J-GLOBAL         Last updated: Jun 26, 2019 at 14:21
 
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Name
Naoki Okumura
Affiliation
Doshisha University
Research funding number
10581499

Profile

I have been developing both pharmaceutical and tissue engineering treatment for corneal endothelial dysfunction. The corneal endothelium is critical for maintaining homeostatic corneal transparency, which it accomplishes by pump and barrier functions. When corneal endothelial cell density decreases to a critical level, the cornea exhibits haziness, with edema, due to decompensation of the corneal endothelial function.

We showed that a Rho-associated kinase (ROCK) inhibitor can be useful in treating corneal endothelial dysfunction. In 2009, we demonstrated that the selective ROCK inhibitor, Y-27632, showed unique effects on cultured CECs: 1) promotion of proliferation; 2) enhancement of cell adhesion; and 3) suppression of apoptosis. Our subsequent studies revealed that administration of ROCK inhibitors in the form of eye drops promotes CEC proliferation in rabbit and monkey in vivo models. In addition to animal experiments, we have started a clinical trial of ROCK inhibitor eye drops in combination for treatment of human corneal endothelial dysfunction patients.

We also demonstrated that in rabbit and monkey corneal endothelial dysfunction models, corneal transparency was restored via the injection of cultivated CECs with the selective ROCK inhibitor into the anterior chamber. One technical obstacle that currently exists is the difficulty of the in vitro expansion of CECs, as they exhibit fibroblastic phenotypes with loss of pump and barrier functions while under the culture conditions. However, we successfully established a CEC culture protocol for clinical use. This protocol enables the efficient in vitro expansion of CECs and may ultimately provide clinicians with a new therapeutic modality in regenerative medicine. Of note, our team has started the first in man clinical trial of cultivated CEC-injection therapy in Japan.

Research Areas

 
 

Academic & Professional Experience

 
Apr 2015
 - 
Today
Associate Professor, Department of Biomedical Engineering, Doshisha university
 
Dec 2011
 - 
Today
Visiting associate professor, Kyoto Prefectural University of Medicine
 
Apr 2011
 - 
Mar 2015
Assistant professor, Doshisha university
 
Apr 2010
 - 
Mar 2011
Assistant professor, Kyoto Prefectural University of Medicine
 
May 2006
 - 
Mar 2010
PhD course student, Kyoto Prefectural University of Medicine
 

Education

 
Apr 2006
 - 
Mar 2010
Kyoto Prefectural University of Medicine PhD course
 
Apr 1995
 - 
Mar 2001
Kyoto Prefectural University of Medicine
 

Awards & Honors

 
2011
“ROCK Inhibitor Regulates the G1-S Progression of Corneal Endothelial Cells”, Association for Research in Vision and Ophthalmology (ARVO) Kowa Travel Grant
 
2010
"The Effect of a ROCK Inhibitor on Corneal Endothelial Cell Migration in an In Vitro Wound-Healing Model", Association for Research in Vision and Ophthalmology (ARVO) International Travel Grant
 
2010
"Therapeutic Potential of a Rho Kinase (ROCK) Inhibitor for the Treatment of Corneal Endothelial Dysfunction", Gordon Research Conference Biology & Pathobiology Of The Cornea Travel Grant
 
2009
"A ROCK Inhibitor Enhances Corneal Endothelial Wound Healing in Both an In vitro and in vivo Model", Association for Research in Vision and Ophthalmology (ARVO) International Travel Grant
 

Published Papers

 
Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy. Cornea. 2019 Jul;38(7):799-805. doi: 10.1097/ICO.0000000000001952. PMID: 30973406
Okumura N, Hayashi R, Nakano M, Tashiro K, Yoshii K, Aleff R, Butz M, Highsmith EW, Wieben ED, Fautsch MP, Baratz KH, Komori Y, Ueda E, Nakahara M, Weller J, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
   Jul 2019   [Refereed]
Feasibility of a cryopreservation of cultured human corneal endothelial cells. PLoS One. 2019 Jun 21;14(6):e0218431. doi: 10.1371/journal.pone.0218431. eCollection 2019. PMID: 31226131
Okumura N, Kagami T, Watanabe K, Kadoya S, Sato M, Koizumi N
   Jun 2019   [Refereed]
Stability, safety, and pharmacokinetics of ganciclovir eye drops prepared from ganciclovir for intravenous infusion. Jpn J Ophthalmol. 2019 May;63(3):289-296. doi: 10.1007/s10384-019-00665-8. Epub 2019 Apr 2.PMID: 30941593
Okumura N, Tanaka T, Fukui Y, Koizumi N
   May 2019   [Refereed]
Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):779-786. doi: 10.1167/iovs.18-25760. PMID: 30811544
Okumura N, Hayashi R, Nakano M, Yoshii K, Tashiro K, Sato T, Blake DJ, Aleff R, Butz M, Highsmith EW, Wieben ED, Fautsch MP, Baratz KH, Komori Y, Nakahara M, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
   Feb 2019   [Refereed]
Cell Based Therapy for Corneal Endothelial Regeneration: Therapy and Surgery. Corneal Regeneration. January 2019. pp.455-462. DOI: 10.1007/978-3-030-01304-2_30.
Koizumi N, Okumura N
   Jan 2019   [Refereed]
Development of Cell Analysis Software to Evaluate Fibroblastic Changes in Cultivated Corneal Endothelial Cells for Quality Control. Cornea. 2018 Dec;37(12):1572-1578. doi: 10.1097/ICO.0000000000001757. PMID: 30234679
Okumura N, Kobayashi K, Ishida N, Kagami T, Hiwa S, Hiroyasu T, Koizumi N
   Dec 2018   [Refereed]
Immune Cells on the Donor Corneal Endothelium After Corneal Transplantation. Cornea. 2018 Sep;37(9):1081-1086. doi: 10.1097/ICO.0000000000001678. PMID: 29952799
Okumura N, Inoue R, Nakano S, Imai H, Matsumoto D, Kayukawa K, Wakimasu K, Kitazawa K, Koizumi N, Kinoshita S
   Sep 2018   [Refereed]
Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation, Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4218-4227. doi: 10.1167/iovs.18-24394. PMID: 30128493.
Nakahara M, Okumura N, Nakano S, Koizumi N
   Aug 2018   [Refereed]
Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy, Open Ophthalmol J. 2018 Jul 23;12:154-163. doi: 10.2174/1874364101812010154. eCollection 2018. Review. PMID: 30123380.
Okumura N, Hayashi R, Koizumi N
   Jul 2018   [Refereed]
Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy, Jpn J Opthalmol, 2018 May 15. doi: 10.1007/s10384-018-0598-1. [Epub ahead of print], PMID: 29766356.
Okumura N, Kusakabe A, Koizumi N, Yoshii K, Wakimasu K, Kayukawa K, Kondo M, Mori K, Sotozono C, Kinoshita S
   May 2018   [Refereed]
The Effect of Posterior Corneal Vesicles on Corneal Endothelial Cell Density and Anisometropic Amblyopia, Cornea, 2018 Jul;37(7):813-817. doi: 10.1097/ICO.0000000000001612. PMID: 29757851.
Noguchi A, Okumura N, Sotozono C, Kinoshita S
   Jul 2018   [Refereed]
Injection of cultured cells with a ROCK inhibitor for bullous keratopathy. N Engl J Med. 2018 Mar 15;378(11):995-1003. doi: 10.1056/NEJMoa1712770, PMID: 29539291.
Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, Tanaka H, Yamamoto Y, Nakamura T, Inatomi T, Bush J, Toda M, Hagiya M, Yokota I, Teramukai S, Sotozono C, Hamuro J
   Mar 2018   [Refereed]
Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. PLoS One. 2018 Jan 16;13(1):e0191306. doi: 10.1371/journal.pone.0191306. eCollection 2018. PMID: 29338061.
Okumura N, Matsumoto D, Fukui Y, Teramoto M, Imai H, Kurosawa T, Shimada T, Kruse F, Schlötzer-Schrehardt U, Kinoshita S, Koizumi N
   Jan 2018   [Refereed]
Involvement of Nectin-Afadin in the Adherens Junctions of the Corneal Endothelium. Cornea. 2018 May;37(5):633-640. doi: 10.1097/ICO.0000000000001526. PMID: 29384809
Okumura N, Kagami T, Fujii K, Nakahara M, Koizumi N
   May 2018   [Refereed]
Rho Kinase in Eye Disease. J Ophthalmol. 2017;2017:9281745. doi: 10.1155/2017/9281745. Epub 2017 Aug 27. PMID: 28928984
Okumura N, Nakao S, Inoue T, Pattabiraman P
   Aug 2017   [Refereed]
Laminin-511 and -521-based matrices for efficient ex vivo-expansion of human limbal epithelial progenitor cells. Sci Rep, 2017 Jul 11;7(1):5152. doi: 10.1038/s41598-017-04916-x. 2017.7.
Polisetti N, Sorokin L, Okumura N, Koizumi N, Kinoshita S, Kruse FE, Schlötzer-Schrehardt U
   Jul 2017   [Refereed]
Corneal Endothelial Cells Have an Absolute Requirement for Cysteine for Survival. Cornea. 2017 May 23. doi: 10.1097/ICO.0000000000001242. 2017.8. PMID: 28542086.
Okumura N, Inoue R, Kakutani K, Nakahara M, Kinoshita S, Hamuro J, Koizumi N
   Aug 2017   [Refereed]
Panoramic view of human corneal endothelial cell layer observed by a prototype slit-scanning wide-field contact specular microscope. Br J Ophthalmol. 2017 May;101(5):655-659.
Tanaka H, Okumura N, Koizumi N, Sotozono C, Sumii Y, Kinoshita S
   May 2017   [Refereed]
Immune Cells on the Corneal Endothelium of an Allogeneic Corneal Transplantation Rabbit Model. Investigative Ophthalmology & Visual Science January 2017, Vol.58, 242-251. doi:10.1167/iovs.16-20019.
Koudouna E, Okumura N, Okazaki Y, Nakano S, Inoue R, Fullwood N, Hori J, Kinoshita S, Koizumi N
   Jan 2017   [Refereed]
A surgical cryoprobe for targeted transcorneal freezing and endothelial cell removal. Journal of Ophthalmology. Volume 2017 (2017), Article ID 5614089, 11 pages. doi.org/10.1155/2017/5614089. 2017.
Akhbanbetova A, Nakano S, Littlechild SL, Young RD, Zvirgzdina M, Fullwood NJ, Weston I, Weston P, Kinoshita S, Okumura N, Koizumi N, Quantock AJ
   May 2017   [Refereed]
Sustained activation of the unfolded protein response induces cell death in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci, 2017 Jul 1;58(9):3697-3707. doi: 10.1167/iovs.16-21023. 2017.7.
Okumura N, Kitahara M, Okuda H, Hashimoto K, Ueda E, Nakahara N, Kinoshita S, Young RD, Quantock AJ, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
   Jul 2017   [Refereed]
The effect of a p38 mitogen-activated protein kinase inhibitor on cellular senescence of cultivated human corneal endothelial cells. Invest Ophthalmol Vis Sci, 2017 Jul 1;58(9):3325-3334. doi: 10.1167/iovs.16-21170. 2017.7.
Hongo A, Okumura N, Nakahara M, Kay EP, Koizumi N
   Jul 2017   [Refereed]
Application of Rho kinase inhibitors for the treatment of corneal endothelial diseases. J Ophthalmol, 2017; 2017:2646904. doi: 10.1155/2017/2646904. Epub 2017 Jul 2. 2017.7.
Okumura N, Kinoshita S, Koizumi N
   Jul 2017   [Refereed]
Development of cell analysis software for cultivated corneal endothelial cells. Cornea. 2017 Nov;36(11):1387-1394. doi: 10.1097/ICO.0000000000001317. 2017.11, PMID: 28834811.
Okumura N, Ishida N, Kakutani K, Hongo A, Hiwa S, Hiroyasu T, Koizumi N
   Nov 2017   [Refereed]
Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy. Sci Rep, 2017 Jul 28;7(1):6801. doi: 10.1038/s41598-017-06924-3. 2017.7.
Okumura N, Hashimoto K, Kitahara M, Okuda H, Ueda E, Watanabe K, Nakahara M, Sato T, Kinoshita S, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
   Jul 2017   [Refereed]
Activation of the Rho/Rho Kinase Signaling Pathway Is Involved in Cell Death of Corneal Endothelium. Investigative Ophthalmology & Visual Science December 2016, Vol.57, 6843-6851. doi:10.1167/iovs.16-20123
Okumura N, Fujii K, Kagami K, Makiko N, Kitahara M, Kinoshita S, Koizumi N
   Dec 2016   [Refereed]
The Role of Rho kinase Inhibitors in Corneal Endothelial Dysfunction. Curr Pharm Des. 2017;23(4):660-666. doi: 10.2174/1381612822666161205110027.2017.
Okumura N, Kinoshita S, Koizumi N
   Apr 2017   [Refereed]
Effect of Trabeculotomy on Corneal Endothelial Cell Loss in Cases of After Penetrating-Keratoplasty Glaucoma. Cornea. 2017 Mar;36(3):317-321. doi: 10.1097/ICO.0000000000001088. PubMed PMID: 28151811.
Kusakabe A, Okumura N, Wakimasu K, Kayukawa K, Kondo M, Koizumi N, Sotozono C, Kinoshita S, Mori K
   Mar 2017   [Refereed]
Okumura N, Sakamoto Y, Fujii K, Kitano J,Nakano S,Tsujimoto Y,Nakamura S,Ueno M,Hagiya M,Hamuro J,Matsuyama A,Suzuki S,Shiina T,Kinoshita S,Koizumi N
   May 2016   [Refereed]
Okumura N,Okazaki Y,Inoue R,Kakutani K,Nakano S,Kinoshita S,Koizumi N
   Mar 2016   [Refereed]
Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells.Sci Rep.Oct 7:5:15005,doi: 10.1038/srep15005,2015.
Okumura N,Kusakabe A,Hirano H,Inoue R,Okazaki Y,Nakano S,Kinoshita S,Koizumi N
   Oct 2015   [Refereed]
Okumura N,Inoue R,Okazaki Y,Nakano S,Nakagawa H,Kinoshita S,Koizumi N
   Sep 2015   [Refereed]
Morphological Changes of Human Corneal Endothelial Cells after Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Administration.A Prospective Open-Label Clinical Study.PLos One.10(9):e0136802.doi: 10.1371,2015.
Nakagawa H,Koizumi N,Okumura N,Suganami H,Kinoshita S
   2015   [Refereed]
Okumura N,Minamiyama R,Ho L,Kay EP,Kawasaki S,Tourtas T,Schlötzer-Schrehardt U,Kruse F,Young RD,Quantock AJ,Kinoshita S,Koizumi N
   2015   [Refereed]
Nakano M,Okumura N,Nakagawa H,Koizumi N,Ikeda Y,Ueno M,Yoshii K,Adachi H,Aleff R,Butz M,Highsmith E,Tashiro K,Wieben E,Kinoshita S,Baratz K
   2015   [Refereed]
Okumura N,Kakutani K,Numata R,Nakahara M,Schlötzer-Schrehardt U,Kruse K,Kinoshita S,Koizumi N.
   2015   [Refereed]
New therapeutic modality for corneal endothelial disease using Rho-associated kinase inhibitor eye drops.Cornea.Suppl 11:S25-31,2014.
Koizumi N,Okumura N,Ueno M,Kinoshita S
   2014   [Refereed]
Cell-based approach for treatment of corneal endothelial dysfunction.Cornea.Suppl 11:S37-41,2014.
Okumura N,Kinoshita S,Koizumi N
   2014   [Refereed]
Cell surface markers of functional phenotypic corneal endothelial cells.Invest Ophthalmol Vis Sci.55(11):7610-7618,2014.
Okumura N,Hirano H,Numata R,Nakahara M,Ueno M,Hamuro J,Kinoshita S,Koizumi N
   2014   [Refereed]
Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media.PLoS One.9(12):e112291,2014.
Fukuta M,Nakai Y,Kirino K,Nakagawa M,Sekiguchi K,Nagata S,Matsumoto Y,Yamamoto T,Umeda K,Heike T,Okumura N,Koizumi N,Sato T,Nakahata T,Saito M,Otsuka T,Kinoshita S,Ueno M,Ikeya M,Toguchida J
   2014   [Refereed]
Frisco H L,Watanabe M,Okumura N,Kusamori K,Takemoto N,Takaya J,Sato S,Yamazoe S,Takakura Y,Kinoshita S,Nishikawa M,Koizumi N,Uesugi M
   2014   [Refereed]
Numata R,Okumura N,Nakahara M,Ueno M,Kinoshita S,Kanematsu D,Kanemura Y,Sasai Y,Koizumi N
   2014   [Refereed]
Human Corneal Endothelium Regeneration.Effect of ROCK Inhibitor.Invest Ophthalmol Vis Sci.19:54(8):5594-5595,2013.
Koizumi N,Okumura N,Kinoshita S.
   2013   [Refereed]
Ferret animal model of corneal endothelial dysfunction for evaluation of drug effect on corneal endothelial wound healing.Anim Eye Res.32:15-21,2013.
Sakamoto Y,Okumura N,Koizumi N,Numata R,Kitano J,Yamamoto M,Komada T,Hoshi N
   2013   [Refereed]
Nakahara M,Okumura N,Kay EP,Hagiya M,Imagawa K,Hosoda Y,Kinoshita S,Koizumi N
   2013   [Refereed]
Corneal Endothelial Cell Fate is Maintained by LGR5 via the Regulation of Hedgehog and Wnt Pathway.Stem Cells.31(7):1396-1407,2013.
Hirata-Tominaga K,Nakamura T,Okumura N,Kay EP,Barrandon Y,Koizumi N,Kinoshita S
   2013   [Refereed]
The ROCK Inhibitor Eye Drop Accelerates Corneal Endothelium Wound Healing.Invest Ophthalmol Vis Sci.3:54(4):2493-2502,2013.
Okumura N,Koizumi N,Kay EP,Ueno M,Sakamoto Y,Nakamura S,Hamuro J,Kinoshita S
   2013   [Refereed]
Rho-associated kinase inhibitor eye drop treatment as a possible medical treatment for Fuchs corneal dystrophy.Cornea.:32(8):1167-1170,2013.
Koizumi N,Okumura N,Ueno M,Nakagawa H,Hamuro J,Kinoshita S
   2013   [Refereed]
Ferret as a New Experimental Animal Model for Corneal Endothelial Research.Anim.Eye Res.31:3-11,2013.
Sakamoto Y,Okumura N,Koizumi N,Yamasaki K,Kitano J,Numata R,Komada T,Hoshi N
   2013   [Refereed]
Development of new therapeutic modalities for corneal endothelial disease focused on the proliferation of corneal endothelial cells using animal models.Exp Eye Res.95(1): 60-67,2012.
Koizumi N,Okumura N,Kinoshita S
   2012   [Refereed]
A selective inhibitor of the Rho kinase pathway,Y-27632,and its influence on wound healing in the corneal stroma.Mol Vis.18:1727-1739,2012.
Yamamoto M,Quantock AJ,Young RD,Okumura N,Ueno M,Sakamoto Y,Kinoshita S,Koizumi N
   2012   [Refereed]
A ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue,Am J Pathol.181(7): 268-277,2012.
Okumura N,Koizumi N,Ueno M,Sakamoto Y, Takahashi H, Tsuchiya H, Hamuro J, Kinoshita S
   2012   [Refereed]
Epithelial-Mesenchymal Transition-Like Phenotypic Changes of Retinal Pigment Epithelium Induced by TGFβ are Prevented by PPARγ Agonists.Invest Ophthalmol Vis Sci.5:53(11):6955-6963,2012.
Hatanaka H,Koizumi N,Okumura N,Kay EP,Mizuhara E,Hamuro J,Kinoshita S
   2012   [Refereed]
Hatanaka H,Koizumi N,Okumura N,Takahashi H,Tanioka H,Young RD,Jones FE,Quantock AJ,Kinoshita S
   2012   [Invited]
Enhancement of corneal endothelium wound healing by a ROCK inhibitor eye drop.Br J Ophthalmol.95(7): 1006-1009,2011.
Okumura N,Koizumi N,Ueno M,Sakamoto Y,Takahashi H,Hirata K,Torii R,Hamuro J,Kinoshita S
   2011   [Refereed]
The New Therapeutic Concept of Using a Rho Kinase (ROCK) Inhibitor for the Treatment of Corneal Endothelial Dysfunction.Cornea.30 suppl 1:S54-59,2011.
Okumura N,Koizumi N,Ueno M,Sakamoto Y,Takahashi H,Hamuro J,Kinoshita S
   2011   [Invited]
A ROCK inhibitor enhances survival of primate corneal endothelial cells in vitro.Invest Ophthalmol Vis Sci.50(8):3680-3687,2009.
Okumura N,Ueno M,Koizumi N,Sakamoto Y,Hirata K,Hamuro J,Kinoshita S
   2009   [Refereed]
Cultivated corneal endothelial transplantation in a primate.possible future clinical application in corneal endothelial regenerative medicine.Cornea.27 Suppl 1: S48-55,2008.
Koizumi N,Sakamoto Y,Okumura N,Tsuchiya H,Torii R,Cooper LJ,et al.
   2008   [Invited]
Cultivated corneal endothelial cell sheet transplantation in a primate model.Invest Ophthalmol Vis Sci.48: 4519-4526,2007.
Koizumi N,Sakamoto Y,Okumura N,Okahara N,Tsuchiya H,Torii R,Cooper LJ, Ban Y, Tanioka H, Kinoshita S
   2007   [Refereed]
Pharmacokinetic analysis of platelet-activating factor in the tears of guinea pigs with allergic conjunctivitis.J Ocul Pharmacol Ther.22:347-352,2006.
Okumura N,Fukushima A,Igarashi A,Sumi T,Yamagishi T,Ueno H
   2006   [Refereed]
Platelet-activating factor in human normal tears.Curr Eye Res.30:891-896,2005.
Okumura N,Kojima K,Hashida M,Koura Y,Fukushima A,Ueno H
   2005   [Refereed]

Misc

 
Rhoキナーゼ阻害薬(リパスジル)の角膜内皮創傷治癒に対する影響.日本眼科学会雑誌 120(7): 503,2016.6.
奥村直毅,岡崎友吾,井上亮太,角谷和哉、中野新一郎,木下茂,小泉範子
   Jun 2016

Conference Activities & Talks

 
Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases, APAO2019, Bangkok, Thailand, 2019.3.8.
Naoki Okumura
8 Mar 2019   
Future pharmaceutical treatment for the treatment of Fuchs’ endothelial corneal dystrophy, BBSRC Japan Partnering Award Symposium, Eye Research in Japan and The UK and The Application of Stem Cell Technology, Osaka, Japan, 2018.12.7.
Naoki Okumura
7 Dec 2018   
Involvement of mitochondria-associated endoplasmic reticulum membrane in the pathophysiology of Fuchs endothelial corneal dystrophy. The 11th Joint Meeting of Japan-China-Korea Ophthalmologists, Fukuoka, Japan, 2018.12.1.
Matsumoto S, Okumura N, Okuda H, Ursula Schlötzer-Schrehardt, Friedrich E. Kruse, Robert D. Young, Andrew J. Quantock, and Koizumi N
1 Dec 2018   
Translational Research of Cultured Corneal Endothelial Cell Transplantation, 2018 TERMIS World Congress, Kyoto, Japan, 2018.9.7.
Naoki Okumura
7 Sep 2018   
The role of TCF4 in the pathophysiology of Fuchs endothelial corneal dystrophy. The Association for Research in Vision and Ophthalmology 2018, Honolulu, USA, 2018.5.2.(一般口演)
Sato M, Okumura N, Nakahara M, Sato T, Kitazawa K, U. Schlotzer-Schrehardt, F. E. Kruse, Koizumi N
2 May 2018   
Feasibility of decellularized porcine corneal sheet implantation for a “stromal sandwich” for the treatment of keratoconus and keratectasia. The Association for Research in Vision and Ophthalmology 2018, Honolulu, USA, 2018.5.2.(ポスター)
Fukui Y, Okumura N, Matsumoto D, Shimada T, Teramoto M, Imai H, Kurosawa T, F Tseng, D Hsieh, Koizumi N
2 May 2018   
Future therapy: cell-based therapy and drug treatment. The Association for Research in Vision and Ophthalmology 2018, Honolulu, USA, 2018.5.2.(一般口演)
Naoki Okumura
2 May 2018   
Comparison of subfoveal choroidal thickness with the difference between right and left eye in POAG patients. The Association for Research in Vision and Ophthalmology 2018, Honolulu, USA, 2018.4.30.(ポスター)
Mengxue Zhou, Imai K, Mori K, Ikeda Y, Ueno M, Okumura N, Kinoshita S, Sotozono C, Koizumi N
30 Apr 2018   
Establishment of a drug screening system for Fuchs endothelial corneal dystrophy. The Association for Research in Vision and Ophthalmology 2018, Honolulu, USA, 2018.4.30.(ポスター)
Oshima T, Okumura N, Onishi T, Ueda E, Watanabe K, T Tourtas, U Schlotzer-Schrehardt, F E Kruse, Koizumi N
30 Apr 2018   
Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany. The Association for Research in Vision and Ophthalmology 2018, Honolulu, USA, 2018.4.30.(ポスター)
Komori Y, Okumura N, Hayashi R, Nakano M, Tashiro K, Yoshii K, R Aleff, M Butz, E W Highsmith, E Wieben, M P Fautsch, K H Baratz, T Tourtas, U Schlotzer-Schrehardt, F E Kruse, Koizumi N
30 Apr 2018   
Involvement of p38 mitogen-activated protein kinase pathway in Fuchs endothelial corneal dystrophy. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.10.(一般口演)
Onishi T, Okumura N, Hashimoto K, Koizumi N
May 2017   
Wide-field contact specular microscopy analysis of corneal endothelium post trabeculectomy. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.(ポスター)
Matsumoto D, Okumura N, Okazaki Y, Shimada T, Koizumi N, Sotozono C, Kinoshita S, Mori K
May 2017   
Nectin-afadin and N-cadherin-catenin system is involved in the formation of adherens junctions in the corneal endothelium. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.(ポスター)
Kagami T, Okumura N, Nakahara M, Koizumi N
May 2017   
Expression level of the TCF4 gene in the corneal endothelium of Fuchs endothelial corneal dystrophy patients. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.(ポスター)
Hayashi R, Okumura N, Ogata K, Nakano M, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
May 2017   
Feasibility of caspase inhibitor to treat Fuchs endothelial corneal dystrophy. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.(ポスター)
Endo M, Okumura N, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
May 2017   
Activation of an intrinsic pathway by endoplasmic reticulum stress in corneal endothelial cells. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.(ポスター)
Okuda H, Okumura N, Kitahara M, Hashimoto K, Koizumi N
May 2017   
Feasibility of TGF-β inhibition for the treatment of Fuchs endothelial corneal dystrophy.The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.(ポスター)
Okumura N, Hashimoto K, Okuda H, Ueda E, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
May 2017   
The Long and Winding Road: From Novel Insights to Practical Application. 第121回日本眼科学会総会, 東京2017.4.7.
Naoki Okumura
Apr 2017   
Sustained Activation of Unfolded Protein Response Induces Cell Death in Fuchs Endothelial Corneal Dystrophy. The 5th Biennial Scientific Meeting Asia Cornea Society (ACS 2016) , Seoul,Korea, 2016.12.9.
Okumura N
Dec 2016   
Translational Research for Corneal Endothelial Disease.Lecture in Cardiff university,Wales,UK,2016.8.10.
Naoki Okumura
Aug 2016   
再生医療で光を取り戻す、角膜再生医療の最前線.駿台予備学校 生命医科学特別講演会, 大阪, 2016.5.26.
Naoki Okumura
May 2016   
The effect of p38 mitogen-activated protein kinase inhibitor on cell density and phenotype of cultivated human corneal endothelial cells.The Association for Research in Vision and Ophthalmology 2016,Seattle,USA,2016.5.4.(ポスター)
Hongo A,Okumura N,Nakahara M,Koizumi N
May 2016   
Effect of the rho-associated kinase inhibitor eye drop ripasudil on corneal endothelial wound healing in a rabbit corneal endothelial damage model. The Association for Research in Vision and Ophthalmology 2016, Seattle, USA, 2016.5.4.
Shimada T,Okumura N,Inoue R,Okazaki Y,Nakano S,Kinoshita S,Koizumi N
May 2016   
p38 mitogen-activated protein kinase inhibitor suppresses apoptosis in a Fuchs endothelial corneal dystrophy cellular model.The Association for Research in Vision and Ophthalmology 2016,Seattle,USA,2016.5.4.(ポスター)
Onishi T,Okumura N,Kusakabe A,Kitahara M,Hashimoto K,Nakahara M,Ueda E,Tourtas T,Schlötzer-Schrehardt U,Kruse F,Koizumi N
May 2016   
Feasibility of cell preservation as a form of cell suspension for a cell-based therapy in a rabbit corneal endothelial dysfunction model.The Association for Research in Vision and Ophthalmology 2016,Seattle,USA,2016.5.4.(ポスター)
Matsumoto D,Okumura N,Inoue R,Okazaki Y,Kinoshita S,Koizumi N
May 2016   
Effect of rho-associated kinase inhibitor eye drop (ripasudil) on morphology of corneal endothelial cells in humans and rabbits.The Association for Research in Vision and Ophthalmology 2016,Seattle,USA,2016.5.4.(ポスター)
Koizumi N,Okumura N,Okazaki Y,Inoue R,Nakano S,Suganami H,Fullwood N,Nakagawa H,Kinoshita S
May 2016   
Trinucleotide repeat expansion and TCF4 gene expression in Fuchs endothelial corneal dystrophy.The Association for Research in Vision and Ophthalmology 2016,Seattle,USA,2016.5.3.
Ogata K,Okumura N,Hayashi R,Nakahara M,Nakano M,Tashiro K,Kinoshita S,Schlötzer-Schrehardt U,Tourtas T,Kruse F,Koizumi N
May 2016   
Unfolded protein accumulation induced endoplasmic reticulum stress of corneal endothelial cells in Fuchs endothelial corneal dystrophy.The Association for Research in Vision and Ophthalmology 2016,Seattle,USA,2016.5.3.
Okumura N,Hashimoto K,Kitahara M,Nakahara M,Kinoshita S,Tourtas T,Schlötzer-Schrehardt U,Kruse F,Koizumi N
May 2016   
Cultivaled Corneal Endothelial Cell Transplantation.The 31st Asia-Pacific Academy of Ophthalmology Congress (APAO 2016) Taipei,Taiwan,2016.3.24
Naoki Okumura
Mar 2016   
Endotheial Cell Transplantation and Regeneration. DOG congress 2015, Berlin, Germany, 2015.10.4.
Naoki Okumura
Oct 2015   
How to make cornea endothelial cells. 6th EuCornea Congress, XXXIII Congress of the ESCRS, Barcelona, Spain, 2015.9.5.
Naoki Okumura
Sep 2015   
Development of Cell Therapy for the Treatment of Corneal Endothelial Dysfunction. Chulalongkorn Eye Center, Thailand.2015.8.19.
Naoki Okumura
Aug 2015   
An allogeneic transplantation trial of cynomolgus monkey ipsc-derived corneal endothelial-like cells.The International Society for Stem Cell Research.Stockholm,Sweden,2015.6.24.
Yoshida S,Hatou S,Okumura N,Koizumi N,Kinoshita S,Tsujikawa M,Hayashi R,Nishida K,Tsubota K,Shimmura S
Jun 2015   
Clinical research of cultured corneal endothelial transplantation. The Association for Research in Vision and Ophthalmology 2015, Colorado, USA, 2015.5.4.
Naoki Okumura
May 2015   
Existence of inflammatory cells on donor corneal endothelium in a Descemet’s stripping automated endothelial keratoplasty rabbit model.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.6.(ポスター)
Koudouna E,Okumura N,Nakano S,Inoue R,Fullwood N,Okazaki S,Kinoshita S,Koizumi N
May 2015   
Rho-associated protein kinase inhibitor suppresses corneal endothelial cell apoptosis by suppressing cell contraction via inhibiting myosin light chain phosphorylation.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.5.
Fujii K,Okumura N,Odajima A,Ueno M,Kinoshita S,Koizumi N
May 2015   
Morphological and functional evaluation of mitochondria in a Fuchs’ endothelial corneal dystrophy cell model.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.3.(ポスター)
Kitahara M,Okumura N,Schlotzer-Schrehardt U,Kruse FE,Young RD,Quantock AJ,Kinoshita S,Koizumi N
May 2015   
Effect of the cell density of cultivated corneal endothelial cells on tissue engineering for the treatment of corneal endothelial dysfunction.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.3.(ポスター)
Okumura N,Nakano S,Kusakabe A,Inoue R,Okazaki Y,Kakutani K,Kinoshita S,Koizumi N
May 2015   
Feasibility of Descemet’s membrane removal during cultivated corneal endothelial cell injection in rabbit and monkey models.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.3.(ポスター)
Koizumi N,Okumura N,Nakano S,Kitano J,Kinoshita S
May 2015   
Purification of high cell density cultured corneal endothelial cell by density-gradient centrifugation.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.3.(ポスター)
Kusakabe A,Okumura N,Hirano H,Koizumi N,Kinoshita S
May 2015   
Investigation of the donor tissue information on the phenotypes of cultivated human corneal endothelium.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.3.(ポスター)
Tanaka H,Ueno M,Toda M,Hamuro J,Yoshii K,Koizumi N,Okumura N,Kinoshita S,Montoya M,Iliakis B
May 2015   
The feasibility of recombinant human laminin-511 E8 fragments for human corneal endothelial cell cultivation.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.3.(ポスター)
Kakutani K,Okumura N,Schlotzer-Schrehardt U,Kruse FE,Kinoshita S,Koizumi N
May 2015   
The different binding properties of cultured human corneal endothelial cell subpopulations to Descemet’s membrane components.The Association for Research in Vision and Ophthalmology 2015.Colorado,USA,2015.5.3.(ポスター)
Toda M,Ueno M,Hiraga A,Asada K,Nakamura T,Hagiya M,Okumura N,Koizumi N,Hamuro J,Kinoshita S
May 2015   
角膜内皮障害に対する新しい治療法の開発〜再生医療と薬物療法〜. 京滋眼科臨床懇話会, 京都, 2015.4.25.
Naoki Okumura
Apr 2015   
R-spondin1の角膜内皮細胞増殖に対する影響.角膜カンファランス2015第39回日本角膜学会総会・第31回日本角膜移植学会,高知 ,2015.2.12.
Feb 2015   
Cell-injection therapy for the treatment of corneal endothelial dysfunction.第118回日本眼科学会総会,東京2014.4.3.(WOC2014 Otsuka morning seminar)
Okumura N
Apr 2014   
霊長類水疱性角膜症モデルを用いた培養角膜内皮細胞移植の有用性および安全性評価.第13回日本再生医療学会総会, 京都, 2014.3.6.
小泉範子、奥村直毅、椎名隆、鈴木進悟、中村紳一朗、上野盛夫、羽室淳爾、松山晃文、木下茂
Mar 2014   
ROCK-inhibiter Suppressed Apoptosis of Corneal Endothelial Cells by Inhibiting Membrane Blebbing.The Association for Research in Vision and Ophthalmology 2014.Florida,USA,2014.5.6.
Fujii K,Okumura N,Kay EP,Nakahara M,Odajima A,Ueno M,Kinoshita S,Koizumi N
2014   
ROCK Inhibitor Suppresses Apoptosis of Corneal Endothelial Cells by Inhibiting MLC phosphorylation. 4th Biennial Scientific Meeting Asia Cornea Society. Taipei, Taiwan, 2014.12.11.
Naoki Okumura
2014   
Involvement of transforming growth factor beta in extracellular matrix deposition and endoplasmic reticulum stress in FUCHS' corneal dystrophy.The International Society for Eye Research XXI Biennial Meeting,San Francisco,California,USA,2014.7.22.
Okumura N,Minamiyama R,Kay EP,Ho L,Kawasaki S,Young R,Quantock A,Schlotzer-Schrehardt U,Kruse F,Kinoshita S,Koizumi N
2014   
Modulating Cell Adhesion Property Enables Cell-based Therapy for Corneal Endothelial Dysfunction.The Association for Research in Vision and Ophthalmology 2014.Florida,USA,2014.5.7.
Okumura N
2014   
The efficiency of laminin-511 and laminin-521 as extracellular matrix for human corneal endothelial cell culture.The Association for Research in Vision and Ophthalmology 2014.Florida,USA,2014.5.5.(ポスター)
Kakutani K,Okumura N,Numata R,Schlotzer-Schrehardt U,Kruse F,Kinoshita S,Koizumi N
2014   
The effect of cell density on the adhesion and proliferation properties of cultivated corneal endothelial cells.The Association for Research in Vision and Ophthalmology 2014.Florida,USA,2014.5.5.(ポスター)
Kusakabe A,Okumura N,Hirano H,Kinoshita S,Koizumi N
2014   
The involvement of transforming growth factor beta on excessive extracellular matrix production of corneal endothelial cells in Fuchs’ endothelial corneal dystrophy.The Association for Research in Vision and Ophthalmology 2014.Florida,USA,2014.5.6.
Koizumi N,Okumura N,Ho L,Kay EP,Kawasaki S,Tourtas T,Schlotzer-Schrehardt U,Kruse F,Kinoshita S
2014   
The involvement of transforming growth factor beta in endoplasmic reticulum stress of corneal endothelial cells in Fuchs’ endothelial corneal dystrophy.The Association for Research in Vision and Ophthalmology 2014.Florida,USA,2014.5.5.(ポスター)
Okumura N,Minamiyama R,Kay EP,Kawasaki S,Young R,Quantock A,Schlotzer-Schrehardt U,Friedrich EK,Kinoshita S,Koizumi N
2014   
Cell-Based Approach for the Treatment of Corneal Endothelial Dysfunction.Gordon Research Conference.California,USA,2014.2.17.
Okumura N
2014   
The Effect of EMT-Related Genes on the Regulation of Excessive Production of Extracellular Matrix in a Cellular Model of Fuchs’ Corneal Dystrophy.Gordon Research Conference.California,USA,2014.2.17.
Okumura N,Leona Ho,EunDuck P.Kay,Kawasaki S,Theofilos Tourtas,Schlotzer-Schrehardt U,Kruse FE,Kinoshita S,Koizumi N
2014   
Rhoキナーゼ阻害剤の角膜内皮細胞に対するアポトーシス抑制効果の検討.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山, 2013.2.14.
小田嶋愛、奥村直毅、Eunduck P Kay、陳文、上野盛夫、木下茂、小泉範子
2013   
Effect of SAHA on Fibrotic Change in Primate Retinal Pigment Epithelium Cells and Vitreous Cells. The Association for Research in Vision and Ophthalmology 2013. Seattle, USA, 2013.5.9.
2013   
Integral Analysis of Gene Signatures and MicroRNA Expression of Cultured Human Corneal Endothelial Cells in Relation to Their Functions,Cell Senescence,Epithelial-Mesenchymal Transition,and Fibrosis.The Association for Research in Vision and Ophthalmology
Asada K,Toda M,Hagiya M,Nakata K,Ueno M,Okumura N,Koizumi N,Hamuro J,Kinoshita S
2013   
Development of a Human Cultivated Nasal Mucosal Epithelial Cell Sheet for the Treatment of Severe Ocular Surface Diseases.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Kobayashi M,Nakamura T,Yasuda M,Hata Y,Okura S,Okumura N,Koizumi N,Yasu H,Kinoshita S
2013   
Activation of the Rho/ROCK Signaling Pathway in the Apoptosis of Corneal Endothelial Cells.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.
Okumura N,Odajima A,EunDuck P.Kay,Chen W,Ueno M,Hamuro J,Kinoshita S,Koizumi N
2013   
Efficacy and Safety Evaluation of Cell-Injection Therapy using Cultivated Human Corneal Endothelial Cells.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.
Koizumi N,Okumura N,Shiina T,Suzuki S,Nakamura S,Sakamoto Y,Yamasaki K,Ueno M,Hamuro J,Kinoshita S
2013   
Rho kinase inhibitor promotes cell adhesion of corneal endothelial cells through inhibiting phosphorylation of MLC.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Tsujimoto Y,Okumura N,EunDuck P.Kay,Numata R,Kinoshita S,Koizumi N
2013   
Effect of ROCK inhibiter on Apoptosis in Corneal Endothelial Cells.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Odajima A,Okumura N,EunDuck P.Kay,Chen W,Ueno M,Kinoshita S,Koizumi N
2013   
Cell-injection Therapy Using Rho Kinase Inhibitor in a Corneal Endothelial Dysfunction Rabbit Model.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Kitano J,Okumura N,EunDuck P.Kay,Ueno M,Hamuro J,Kinoshita S,Koizumi N
2013   
Proliferation Propensity of Cultured Human Corneal Endothelial Cells and Their Plasticity Dictated by Culture Microenvironments.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Toda M,Nakata K,Asada K,Hagiya M,Ueno M,Okumura N,Koizumi N,Hamuro J,Kinoshita S
2013   
Rho-kinase inhibitor enhances corneal endothelial cell proliferation via p27 degradation.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Numata R,Okumura N,EunDuck P.Kay,Nakahara M,Nakano S,Ueno M,Kinoshita S,Koizumi N
2013   
Controlled Release of a Rho Kinase (ROCK)-Selective Inhibitor with Polylactic Acid Microspheres.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Koda S,Saito T,Kitano J,Okumura N,Kinoshita S,Tabata Y,Koizumi N
2013   
Cell Line of Fuchs' Corneal Dystrophy Produces an Abnormal Extracellular Matrix.The Association for Research in Vision and Ophthalmology 2013.Seattle,USA,2013.5.6.(ポスター)
Leona Ho,Okumura N,EunDuck P.Kay,Yamasaki K,Kawasaki S,Tourtas T,Schlotzer-Schrehardt U,Kruse FE,Kinoshita S,Koizumi N
2013   
The establishment of human corneal endothelial cell culture for clinical application.第117回日本眼科学会総会,東京2013.4.4.
Okumura N
2013   
HDAC阻害薬による網膜色素上皮細胞および硝子体細胞の線維性変化への影響.第117回日本眼科学会総会,東京2013.4.4.(ポスター
畑中宏樹,小泉範子,奥村直毅,平野浩惇,水原英理,羽室淳爾,木下茂
2013   
Rhoキナーゼ阻害剤の角膜内皮創傷治癒に対する影響.第117回日本眼科学会総会,東京,2013.4.4.
小泉範子,奥村直毅,中野新一郎,北野絢嗣,太田礼,坂本雄二,羽室淳爾,上野盛夫,木下茂
2013   
Rhoキナーゼ阻害剤の角膜内皮細胞に対するアポトーシス抑制効果の検討.第117回日本眼科学会総会,東京,2013.4.4.
奥村直毅,小田嶋愛,EunDuck Kay,陳文,上野盛夫,羽室淳爾,木下茂,小泉範子
2013   
Rhoキナーゼ阻害剤を併用した培養角膜内皮細胞移植の開発.第12回日本再生医療学会総会,横浜,2013.3.21.
北野絢嗣,奥村直毅,上野盛夫,中原マキコ,沼田諒平,坂本雄二,羽室淳爾,木下茂,小泉範子
2013   
選択的Rhoキナーゼ阻害剤徐放化ポリ乳酸粒子の作製.第12回日本再生医療学会総会,横浜,2013.3.21.
迎田生,齋藤高志,北野絢嗣,奥村直毅,小泉範子,田畑泰彦
2013   
Rhoキナーゼ阻害剤の角膜内皮細胞に対する増殖促進作用機序の検討.第12回日本再生医療学会総会,横浜,2013.3.21.
沼田諒平,奥村直毅,Kay EunDuck,中原マキコ,上野盛夫,木下茂,小泉範子
2013   
Rhoキナーゼ阻害剤の培養角膜内皮細胞に対する基質接着性促進機序の検討.第12回日本再生医療学会総会,横浜,2013.3.21.
奥村直毅,辻本勇気,Kay EunDuck,沼田諒平,太田礼,上野盛夫,羽室淳爾,木下茂,小泉範子
2013   
難治性眼表面疾患に対する培養鼻粘膜上皮シートの開発.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山,2013.2.14.
小林正和,中村隆宏,安田誠,畑結衣子,大倉翔貴,奥村直毅,小泉範子,久育男,木下茂
2013   
ROCK阻害剤Y-39983の角膜内皮細胞増殖に対する効果の検討.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山,2013.2.14.
中野新一郎,奥村直毅,北野絢嗣,太田礼,坂本雄二,羽室淳爾,上野盛夫,木下茂,小泉範子
2013   
ポリ乳酸粒子を用いた選択的Rhoキナーゼ阻害剤徐放化の検討.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山,2013.2.14.
迎田生,齋藤高志,北野絢嗣,奥村直毅,木下茂,田畑泰彦,小泉範子
2013   
Rhoキナーゼ阻害剤の培養角膜内皮細胞に対する接着促進機序の検討.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山,2013.2.14.
辻本勇気,奥村直毅,Eunduck P Kay,沼田諒平,上野盛夫,羽室淳爾,木下茂,小泉範子
2013   
Rhoキナーゼ阻害剤の霊長類角膜内皮細胞に対する増殖促進機序の解明.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山,2013.2.14.
沼田諒平,奥村直毅,Eunduck P Kay,中原マキ子,上野盛夫,木下茂,小泉範子
2013   
霊長類水疱性角膜症モデルを用いた培養角膜内皮細胞注入療法の有用性および安全性評価.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山,2013.2.14.
奥村直毅,椎名隆, 鈴木進悟,中村紳一朗,坂本雄二,上野盛夫,羽室淳爾,木下茂,松山晃文
2013   
ウサギ水疱性角膜症モデルを用いた培養角膜内皮細胞注入療法の開発.角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会,和歌山,2013.2.14.
北野絢嗣,奥村直毅,山崎健太,中原マキ子,上野盛夫,羽室淳爾,木下茂,小泉範子
2013   
Cultivation of human corneal endothelial cells on a pericellular matrix prepared from human decidua-derived mesenchymal cells.The Association for Research in Vision and Ophthalmology 2012.Florida,USA,2012.5.10.
Numata R,Okumura N,Nakahara M,Ueno M,Kinoshita S,Kanemura Y,Sasai Y,Koizumi N
2012   
Rock inhibitor eye drops accelerate corneal endothelium wound healing in a primate model.The Association for Research in Vision and Ophthalmology 2012.Florida,USA,2012.5.10.
Okumura N,Koizumi N,Ueno M,Sakamoto Y,Takahashi H,Yamasaki K,Torii R,Hamuro J,Kinoshita S
2012   
Effect of the PPARγ agonist on the fibrotic change in primate retinal pigment epithelial cells.The Association for Research in Vision and Ophthalmology 2012.Florida,USA,2012.5.9.
Hatanaka H,Okumura N,Koizumi N,Mizuhara E,Hamuro J,Kinoshita S
2012   
Cell-injection therapy using cultivated human corneal endothelial cells in a primate model.The Association for Research in Vision and Ophthalmology 2012.Florida,USA,2012.5.7.
Koizumi N,Okumura N,Sakamoto Y,Yamasaki K,Nakahara M,Torii R,Ueno M,Hamuro J,Kinoshita S
2012   
New Therapeutic Modality of Using ROCK Inhibitor for Corneal Endothelial Disease,27th Asia-Pacific Academy of Ophthalmology Congress.2012.4.
Okumura N
2012   
Elevated keratan sulphate in the corneal stroma cultured at low oxygen tension,角膜カンファランス2012第36回日本角膜学会総会・第28回日本角膜移植学会,東京,2012.2.23.
Leona T.Y.Ho,Bruce Caterson,Keith M.Meek,Andrew J.Quantock,Okumura N,Koizumi N
2012   
The New Therapeutic Modality of Using a Rho Kinase (ROCK) Inhibitor for the Treatment of Corneal Endothelial Dysfunction.TERMIS Singapore.2011.8.5.
Okumura N
Aug 2011   
New strategy for corneal endothelial tissue engineering, Schepens Eye Research Institute 27th Biennial Cornea Conference.2011.
Koizumi N,Okumura N,Kinoshita S
2011   
ROCK inhibitor as a new therapeutic modality for corneal endothelial dysfunction.5th International Symposium of the UCSD-Doshisha Medical Imaging Research Center,San Diego,USA,2011.12.5.
Okumura N
2011   
Effect of PPARγ agonist on the fibrotic change in retinal pigment epithelium and vitreous cells.Annual Meeting of the Association for Research in Vision and Ophthalmology,Fort Lauderdale,Florida,USA.2011.5.3.(ポスター)
Hatanaka H,Okumura N,Koizumi N,Hamuro J,Kinoshita S
2011   
ROCK Inhibitor Regulates the G1-S Progression of Corneal Endothelial Cells.Annual Meeting of the Association for Research in Vision and Ophthalmology,Fort Lauderdale,Florida,USA.2011.5.5.
Okumura N,Koizumi N,Yamasaki K,Ueno M,Sakamoto Y,Sowa Y,Sakai T,Hamuro J,Kinoshita S
2011   
Cell-Injection Therapy using Cultivated Corneal Endothelial Cells Combined with a ROCK Inhibitor in a Primate Model.Annual Meeting of the Association for Research in Vision and Ophthalmology,Fort Lauderdale,Florida,USA.2011.5.5.
Koizumi N,Okumura N,Yamasaki K,Ueno M,Sakamoto Y,Takahashi H,Torii R,Hamuro J,Kinoshita S
2011