OMASA Takeshi

J-GLOBAL         Last updated: Dec 5, 2019 at 04:39
 
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Name
OMASA Takeshi
E-mail
omasabio.eng.osaka-u.ac.jp
Affiliation
Osaka University
Section
Graduate School of Engineering Division of Science and Biotechnology
Job title
Professor
Research funding number
00252586
ORCID ID
0000-0003-0635-3862

Research Areas

 
 

Academic & Professional Experience

 
May 2010
   
 
教授, 徳島大学大学院ソシオテクノサイエンス研究部
 

Published Papers

 
Analysis of intracellular IgG secretion in Chinese hamster ovary cells to improve IgG production
Kohei Kaneyoshi, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano, Yuichi Koga, and Takeshi Omasa*
Journal of Bioscience and Bioengineering   127(1) 107-113   Jan 2019   [Refereed]
Genome sequence comparison between Chinese hamster ovary (CHO) DG44 cells and mouse using end sequences of CHO BAC clones based on BAC-FISH results.
Shuichi Kimura, and Takeshi Omasa*
Cytotechnology   70(5) 1399-1407   Oct 2018   [Refereed]
The healing effect of human milk fat globule-EGF factor 8 protein (MFG-E8) in a rat model of Parkinson’s disease
Yoshiki Nakashima*, Chika Miyagi-Shiohira, Hirofumi Noguchi and Takeshi Omasa
Brain Science   8(9) 167   Sep 2018   [Refereed]
Atorvastatin inhibits the HIF1α-PPAR axis, which is essential for maintaining the function of human induced pluripotent stem cells
Yoshiki Nakashima*, Chika Miyagi-Shiohira, Hirofumi Noguchi, and Takeshi Omasa
Molecular Therapy   26(7) 1715-1734   Aug 2018   [Refereed]
Development of hyper osmotic resistant CHO host cells for enhanced antibody production.
Yasuharu Kamachi*, and Takeshi Omasa
Journal of Bioscience and Bioengineering   125(4) 470-478   Aug 2018   [Refereed]
Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells.
Masayoshi Onitsuka*, Yukie Kinoshita, Akitoshi Nishizawa, Tomomi Tsutsui and Takeshi Omasa
Cytotechnology   70(2) 675-685   Apr 2018   [Refereed]
The enhancement of antibody concentration and achievement of high cell density CHO cell cultivation by adding nucleoside
Yasuhiro Takagi, Takuya Kikuchi, Ryuta Wada and Takeshi Omasa*
Cytotechnology   69(3) 511-521   Jun 2017   [Refereed]
Improved recombinant antibody production by CHO cells using a production enhancer DNA element with repeated transgene integration at a predetermined chromosomal site
Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Guan Huang, Akira Ito, Takeshi Omasa, and Masamichi Kamihira
Journal of Bioscience and Bioengineering   123(3) 390-397   Mar 2017   [Refereed]
Lengthening of high-yield production levels of monoclonal antibody-producing Chinese hamster ovary cells by downregulation of breast cancer 1
Rima Matsuyama¶, Noriko Yamano¶, Namiko Kawamura, and Takeshi Omasa*(¶:equal contribution)
Journal of Bioscience and Bioengineering   123(3) 382-389   Mar 2017   [Refereed]
Identification of regulatory motifs in the CHO genome for stable monoclonal antibody production
Yasuhiro Takagi, Tomomi Yamazaki, Kenji Masuda, Shigeaki Nishii, Bunsei Kawakami and Takeshi Omasa*
Cytotechnology   69(3) 451-460   Jun 2016   [Refereed]
Increased recombinant protein production owing to expanded opportunities for vector integration in high chromosome number Chinese hamster ovary cells
Noriko Yamano, Mai Takahashi, Seyed Mohammad Ali Haghparast, Masayoshi Onitsuka, Toshitaka Kumamoto, Jana Frank, and Takeshi Omasa
Journal of Bioscience and Bioengineering   122(2) 226-231   Feb 2016   [Refereed]
Rapid colorimetric antibody detection using a dual-function peptide probe for silver nanoparticle aggregation and antibody recognition
Mina Okochi*, Tomohiro Kamiya, Takeshi Omasa, Masayoshi Tanaka, Hiroyuki Honda
Analytical Sciences   32(1) 93-97   Jan 2016   [Refereed]
Metabolic analysis of antibody producing CHO cell culture under different stresses conditions
Md. Bahadur Badsha, Hiroyuki Kurata*, Masayoshi Onitsuka, Takushi Oga, Takeshi Omasa
Journal of Bioscience and Bioengineering   122(1) 117-124   Jan 2016   [Refereed]
Improved gene amplification by cell-cycle engineering combined with the Cre-loxP system in Chinese hamster ovary cells
Rima Matsuyama, Tomomi Tsutsui, Kyoung Ho Lee, Masayoshi Onitsuka, and Takeshi Omasa
Journal of Bioscience and Bioengineering   120(6) 701-708   Jun 2015   [Refereed]
Approaches to quality risk management when using single use systems in the manufacture of biologics
Akiko Ishii-Watabe*, Akihiko Hirose, Noriko Katori, Norikata Hashii, Susumu Arai, Hirotoshi Awatsu, Akira Eiza, Yoshiaki Hara, Hideshi Hattori, Tomomi Inoue, Tetsuya Isono, Masahiro Iwakura, Daisuke Kajihara, Nobuo Kasahara, Hiroyuki Matsuda, Sei Murakami, Taishiro Nakagawa, Takehiro Okumura, Takeshi Omasa, Shinya Takuma, Iyo Terashima, Masayoshi Tsukahara, Maiko Tsutsui, Takahiro Yano, Nana Kawasaki
AAPS PharmSciTech   16(5) 993-1001   May 2015   [Refereed]
Nakamura T, Omasa T
Journal of bioscience and bioengineering      Mar 2015   [Refereed]
Okumura T, Masuda K, Watanabe K, Miyadai K, Nonaka K, Yabuta M, Omasa T
Journal of bioscience and bioengineering      Feb 2015   [Refereed]
Shirai A, Onitsuka M, Maseda H, Omasa T
Biocontrol science   20 27-33   2015   [Refereed]
Onitsuka M, Omasa T
Journal of bioscience and bioengineering      Dec 2014   [Refereed]
Haredy AM, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Mori Y, Kida H, Okamoto S, Okuno Y, Yamanishi K
The Journal of general virology   95 2365-2371   Nov 2014   [Refereed]
Kishimoto N, Momota Y, Hashimoto Y, Tatsumi S, Ando K, Omasa T, Kotani J
Clinical oral investigations   18 1893-1901   Nov 2014   [Refereed]
Asano R, Shimomura I, Konno S, Ito A, Masakari Y, Orimo R, Taki S, Arai K, Ogata H, Okada M, Furumoto S, Onitsuka M, Omasa T, Hayashi H, Katayose Y, Unno M, Kudo T, Umetsu M, Kumagai I
mAbs   6 1243-1254   2014   [Refereed]
Haredy AM, Nishizawa A, Honda K, Ohya T, Ohtake H, Omasa T
Cytotechnology      Sep 2013   [Refereed]
Haredy AM, Takenaka N, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Yamanishi K, Okamoto S
Clinical and vaccine immunology : CVI   20 998-1007   Jul 2013   [Refereed]
Lee KH, Onitsuka M, Honda K, Ohtake H, Omasa T
Applied microbiology and biotechnology   97 5731-5741   Jul 2013   [Refereed]
Lee KH, Tsutsui T, Honda K, Asano R, Kumagai I, Ohtake H, Omasa T
Journal of bioscience and bioengineering      Jun 2013   [Refereed]
Uwate M, Ichise YK, Shirai A, Omasa T, Nakae T, Maseda H
Microbiology and immunology   57 263-272   Apr 2013   [Refereed]
Ninh PH, Honda K, Yokohigashi Y, Okano K, Omasa T, Ohtake H
Applied and environmental microbiology   79 1996-2001   Mar 2013   [Refereed]
Shirai A, Fumoto Y, Shouno T, Maseda H, Omasa T
Biocontrol science   18 59-73   2013   [Refereed]
Shirai A, Endo T, Maseda H, Omasa T
Biocontrol science   18 183-191   2013   [Refereed]
Araki N, Tsuruoka S, Hasegawa G, Yanagihara H, Omasa T, Enosawa S, Yamazoe Y, Fujimura A
The Journal of pharmacy and pharmacology   64 1715-1721   Dec 2012   [Refereed]
Ye X, Honda K, Sakai T, Okano K, Omasa T, Hirota R, Kuroda A, Ohtake H
Microbial cell factories   11 120   Sep 2012   [Refereed]
Honda K, Imura M, Okano K, Omasa T, Kato J, Ohtake H
Bioscience, biotechnology, and biochemistry   76 1758-1764   2012   [Refereed]
Cao Y, Kimura S, Park JY, Yamatani M, Honda K, Ohtake H, Omasa T
BMC proceedings   5 Suppl 8 O8   2011   [Refereed]
Haredy AM, Nishizawa A, Honda K, Ohya T, Ohtake H, Omasa T
BMC proceedings   5 Suppl 8 O11   2011   [Refereed]
Park JY, Takagi Y, Yamatani M, Honda K, Asakawa S, Shimizu N, Omasa T, Ohtake H
Journal of bioscience and bioengineering   109(5) 504-511   May 2010   [Refereed]
Kashihara H, Kang BM, Omasa T, Honda K, Sameshima Y, Kuroda A, Ohtake H
Bioscience, biotechnology, and biochemistry   74(4) 865-868   Apr 2010   [Refereed]
Omasa T, Onitsuka M, Kim WD
Current pharmaceutical biotechnology   11 233-240   Apr 2010   [Refereed]
Zhou Y, Minami T, Honda K, Omasa T, Ohtake H
Applied microbiology and biotechnology   87(2) 647-655   Mar 2010   [Refereed]
Kim WD, Tokunaga M, Ozaki H, Ishibashi T, Honda K, Kajiura H, Fujiyama K, Asano R, Kumagai I, Omasa T, Ohtake H
Applied microbiology and biotechnology   85(3) 535-542   Jan 2010   [Refereed]
Omasa T, Furuichi K, Iemura T, Katakura Y, Kishimoto M, Suga K
Bioprocess and biosystems engineering   33(1) 117-125   Jan 2010   [Refereed]
Omasa T, Cao Y, Park JY, Takagi Y, Kimura S, Yano H, Honda K, Asakawa S, Shimizu N, Ohtake H
Biotechnology and bioengineering   104(5) 986-994   Dec 2009   [Refereed]
Hamada T, Maeda Y, Matsuda H, Sameshima Y, Honda K, Omasa T, Kato J, Ohtake H
Journal of bioscience and bioengineering   108(2) 116-120   Aug 2009   [Refereed]
Fujiyama K, Misaki R, Sakai Y, Omasa T, Seki T
Journal of bioscience and bioengineering   107(2) 165-172   Feb 2009   [Refereed]
Omasa T, Takami T, Ohya T, Kiyama E, Hayashi T, Nishii H, Miki H, Kobayashi K, Honda K, Ohtake H
Journal of bioscience and bioengineering   106(6) 568-573   Dec 2008   [Refereed]
Atorvastatin inhibits the HIF1α-PPAR axis, which is essential for maintaining the function of human induced pluripotent stem cells
Yoshiki Nakashima, Chika Miyagi-Shiohira, Hirofumi Noguchi, Takeshi Omasa
Molecular Therapy   26(7) 1715-1734   Jul 2018   [Refereed]
Genome sequence comparison between Chinese hamster ovary (CHO) DG44 cells and mouse using end sequences of CHO BAC clones based on BAC-FISH results
Shuichi Kimura, Takeshi Omasa
Cytotechnology   70(5) 1399-1407   Oct 2018   [Refereed]
The healing effect of human milk fat globule-EGF factor 8 protein (MFG-E8) in a rat model of Parkinson's disease
Yoshiki Nakashima, Chika Miyagi-Shiohira, Hirofumi Noguchi, Takeshi Omasa
Brain Science   8(9) 167   Oct 2018   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2007    Investigator(s): Takeshi OMASA
Gene amplification means "the selective, repeated replication of a certain gene or genes without a proportional increase in other genes in the genome". Gene amplification is a widespread phenomenon in eukaryotes. It is an important process in the ...