OMASA Takeshi Last updated: Dec 5, 2019 at 04:39
Name
OMASA Takeshi E-mail
omasa bio.eng.osaka-u.ac.jp Affiliation
Osaka University Section
Graduate School of Engineering Division of Science and Biotechnology Job title
Professor Research funding number
00252586 ORCID ID
0000-0003-0635-3862
Academic & Professional Experience
May 2010
教授, 徳島大学大学院ソシオテクノサイエンス研究部
Published Papers
Analysis of intracellular IgG secretion in Chinese hamster ovary cells to improve IgG production
Kohei Kaneyoshi, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano, Yuichi Koga, and Takeshi Omasa*
Journal of Bioscience and Bioengineering 127(1) 107-113 Jan 2019 [Refereed]
Genome sequence comparison between Chinese hamster ovary (CHO) DG44 cells and mouse using end sequences of CHO BAC clones based on BAC-FISH results.
Shuichi Kimura, and Takeshi Omasa*
Cytotechnology 70(5) 1399-1407 Oct 2018 [Refereed]
The healing effect of human milk fat globule-EGF factor 8 protein (MFG-E8) in a rat model of Parkinson’s disease
Yoshiki Nakashima*, Chika Miyagi-Shiohira, Hirofumi Noguchi and Takeshi Omasa
Brain Science 8(9) 167 Sep 2018 [Refereed]
Atorvastatin inhibits the HIF1α-PPAR axis, which is essential for maintaining the function of human induced pluripotent stem cells
Yoshiki Nakashima*, Chika Miyagi-Shiohira, Hirofumi Noguchi, and Takeshi Omasa
Molecular Therapy 26(7) 1715-1734 Aug 2018 [Refereed]
Development of hyper osmotic resistant CHO host cells for enhanced antibody production.
Yasuharu Kamachi*, and Takeshi Omasa
Journal of Bioscience and Bioengineering 125(4) 470-478 Aug 2018 [Refereed]
Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells.
Masayoshi Onitsuka*, Yukie Kinoshita, Akitoshi Nishizawa, Tomomi Tsutsui and Takeshi Omasa
Cytotechnology 70(2) 675-685 Apr 2018 [Refereed]
The enhancement of antibody concentration and achievement of high cell density CHO cell cultivation by adding nucleoside
Yasuhiro Takagi, Takuya Kikuchi, Ryuta Wada and Takeshi Omasa*
Cytotechnology 69(3) 511-521 Jun 2017 [Refereed]
Improved recombinant antibody production by CHO cells using a production enhancer DNA element with repeated transgene integration at a predetermined chromosomal site
Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Guan Huang, Akira Ito, Takeshi Omasa, and Masamichi Kamihira
Journal of Bioscience and Bioengineering 123(3) 390-397 Mar 2017 [Refereed]
Lengthening of high-yield production levels of monoclonal antibody-producing Chinese hamster ovary cells by downregulation of breast cancer 1
Rima Matsuyama¶, Noriko Yamano¶, Namiko Kawamura, and Takeshi Omasa*(¶:equal contribution)
Journal of Bioscience and Bioengineering 123(3) 382-389 Mar 2017 [Refereed]
Identification of regulatory motifs in the CHO genome for stable monoclonal antibody production
Yasuhiro Takagi, Tomomi Yamazaki, Kenji Masuda, Shigeaki Nishii, Bunsei Kawakami and Takeshi Omasa*
Cytotechnology 69(3) 451-460 Jun 2016 [Refereed]
Increased recombinant protein production owing to expanded opportunities for vector integration in high chromosome number Chinese hamster ovary cells
Noriko Yamano, Mai Takahashi, Seyed Mohammad Ali Haghparast, Masayoshi Onitsuka, Toshitaka Kumamoto, Jana Frank, and Takeshi Omasa
Journal of Bioscience and Bioengineering 122(2) 226-231 Feb 2016 [Refereed]
Rapid colorimetric antibody detection using a dual-function peptide probe for silver nanoparticle aggregation and antibody recognition
Mina Okochi*, Tomohiro Kamiya, Takeshi Omasa, Masayoshi Tanaka, Hiroyuki Honda
Analytical Sciences 32(1) 93-97 Jan 2016 [Refereed]
Metabolic analysis of antibody producing CHO cell culture under different stresses conditions
Md. Bahadur Badsha, Hiroyuki Kurata*, Masayoshi Onitsuka, Takushi Oga, Takeshi Omasa
Journal of Bioscience and Bioengineering 122(1) 117-124 Jan 2016 [Refereed]
Improved gene amplification by cell-cycle engineering combined with the Cre-loxP system in Chinese hamster ovary cells
Rima Matsuyama, Tomomi Tsutsui, Kyoung Ho Lee, Masayoshi Onitsuka, and Takeshi Omasa
Journal of Bioscience and Bioengineering 120(6) 701-708 Jun 2015 [Refereed]
Approaches to quality risk management when using single use systems in the manufacture of biologics
Akiko Ishii-Watabe*, Akihiko Hirose, Noriko Katori, Norikata Hashii, Susumu Arai, Hirotoshi Awatsu, Akira Eiza, Yoshiaki Hara, Hideshi Hattori, Tomomi Inoue, Tetsuya Isono, Masahiro Iwakura, Daisuke Kajihara, Nobuo Kasahara, Hiroyuki Matsuda, Sei Murakami, Taishiro Nakagawa, Takehiro Okumura, Takeshi Omasa, Shinya Takuma, Iyo Terashima, Masayoshi Tsukahara, Maiko Tsutsui, Takahiro Yano, Nana Kawasaki
AAPS PharmSciTech 16(5) 993-1001 May 2015 [Refereed]
Nakamura T, Omasa T
Journal of bioscience and bioengineering Mar 2015 [Refereed]
Okumura T, Masuda K, Watanabe K, Miyadai K, Nonaka K, Yabuta M, Omasa T
Journal of bioscience and bioengineering Feb 2015 [Refereed]
Shirai A, Onitsuka M, Maseda H, Omasa T
Biocontrol science 20 27-33 2015 [Refereed]
Onitsuka M, Omasa T
Journal of bioscience and bioengineering Dec 2014 [Refereed]
Haredy AM, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Mori Y, Kida H, Okamoto S, Okuno Y, Yamanishi K
The Journal of general virology 95 2365-2371 Nov 2014 [Refereed]
Kishimoto N, Momota Y, Hashimoto Y, Tatsumi S, Ando K, Omasa T, Kotani J
Clinical oral investigations 18 1893-1901 Nov 2014 [Refereed]
Asano R, Shimomura I, Konno S, Ito A, Masakari Y, Orimo R, Taki S, Arai K, Ogata H, Okada M, Furumoto S, Onitsuka M, Omasa T, Hayashi H, Katayose Y, Unno M, Kudo T, Umetsu M, Kumagai I
mAbs 6 1243-1254 2014 [Refereed]
Haredy AM, Nishizawa A, Honda K, Ohya T, Ohtake H, Omasa T
Cytotechnology Sep 2013 [Refereed]
Haredy AM, Takenaka N, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Yamanishi K, Okamoto S
Clinical and vaccine immunology : CVI 20 998-1007 Jul 2013 [Refereed]
Lee KH, Onitsuka M, Honda K, Ohtake H, Omasa T
Applied microbiology and biotechnology 97 5731-5741 Jul 2013 [Refereed]
Lee KH, Tsutsui T, Honda K, Asano R, Kumagai I, Ohtake H, Omasa T
Journal of bioscience and bioengineering Jun 2013 [Refereed]
Uwate M, Ichise YK, Shirai A, Omasa T, Nakae T, Maseda H
Microbiology and immunology 57 263-272 Apr 2013 [Refereed]
Ninh PH, Honda K, Yokohigashi Y, Okano K, Omasa T, Ohtake H
Applied and environmental microbiology 79 1996-2001 Mar 2013 [Refereed]
Shirai A, Fumoto Y, Shouno T, Maseda H, Omasa T
Biocontrol science 18 59-73 2013 [Refereed]
Shirai A, Endo T, Maseda H, Omasa T
Biocontrol science 18 183-191 2013 [Refereed]
Araki N, Tsuruoka S, Hasegawa G, Yanagihara H, Omasa T, Enosawa S, Yamazoe Y, Fujimura A
The Journal of pharmacy and pharmacology 64 1715-1721 Dec 2012 [Refereed]
Ye X, Honda K, Sakai T, Okano K, Omasa T, Hirota R, Kuroda A, Ohtake H
Microbial cell factories 11 120 Sep 2012 [Refereed]
Honda K, Imura M, Okano K, Omasa T, Kato J, Ohtake H
Bioscience, biotechnology, and biochemistry 76 1758-1764 2012 [Refereed]
Cao Y, Kimura S, Park JY, Yamatani M, Honda K, Ohtake H, Omasa T
BMC proceedings 5 Suppl 8 O8 2011 [Refereed]
Haredy AM, Nishizawa A, Honda K, Ohya T, Ohtake H, Omasa T
BMC proceedings 5 Suppl 8 O11 2011 [Refereed]
Park JY, Takagi Y, Yamatani M, Honda K, Asakawa S, Shimizu N, Omasa T, Ohtake H
Journal of bioscience and bioengineering 109(5) 504-511 May 2010 [Refereed]
Kashihara H, Kang BM, Omasa T, Honda K, Sameshima Y, Kuroda A, Ohtake H
Bioscience, biotechnology, and biochemistry 74(4) 865-868 Apr 2010 [Refereed]
Omasa T, Onitsuka M, Kim WD
Current pharmaceutical biotechnology 11 233-240 Apr 2010 [Refereed]
Zhou Y, Minami T, Honda K, Omasa T, Ohtake H
Applied microbiology and biotechnology 87(2) 647-655 Mar 2010 [Refereed]
Kim WD, Tokunaga M, Ozaki H, Ishibashi T, Honda K, Kajiura H, Fujiyama K, Asano R, Kumagai I, Omasa T, Ohtake H
Applied microbiology and biotechnology 85(3) 535-542 Jan 2010 [Refereed]
Omasa T, Furuichi K, Iemura T, Katakura Y, Kishimoto M, Suga K
Bioprocess and biosystems engineering 33(1) 117-125 Jan 2010 [Refereed]
Omasa T, Cao Y, Park JY, Takagi Y, Kimura S, Yano H, Honda K, Asakawa S, Shimizu N, Ohtake H
Biotechnology and bioengineering 104(5) 986-994 Dec 2009 [Refereed]
Hamada T, Maeda Y, Matsuda H, Sameshima Y, Honda K, Omasa T, Kato J, Ohtake H
Journal of bioscience and bioengineering 108(2) 116-120 Aug 2009 [Refereed]
Fujiyama K, Misaki R, Sakai Y, Omasa T, Seki T
Journal of bioscience and bioengineering 107(2) 165-172 Feb 2009 [Refereed]
Omasa T, Takami T, Ohya T, Kiyama E, Hayashi T, Nishii H, Miki H, Kobayashi K, Honda K, Ohtake H
Journal of bioscience and bioengineering 106(6) 568-573 Dec 2008 [Refereed]
Atorvastatin inhibits the HIF1α-PPAR axis, which is essential for maintaining the function of human induced pluripotent stem cells
Yoshiki Nakashima, Chika Miyagi-Shiohira, Hirofumi Noguchi, Takeshi Omasa
Molecular Therapy 26(7) 1715-1734 Jul 2018 [Refereed]
Genome sequence comparison between Chinese hamster ovary (CHO) DG44 cells and mouse using end sequences of CHO BAC clones based on BAC-FISH results
Shuichi Kimura, Takeshi Omasa
Cytotechnology 70(5) 1399-1407 Oct 2018 [Refereed]
The healing effect of human milk fat globule-EGF factor 8 protein (MFG-E8) in a rat model of Parkinson's disease
Yoshiki Nakashima, Chika Miyagi-Shiohira, Hirofumi Noguchi, Takeshi Omasa
Brain Science 8(9) 167 Oct 2018 [Refereed]
Research Grants & Projects
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2007 Investigator(s): Takeshi OMASA
Gene amplification means "the selective, repeated replication of a certain gene or genes without a proportional increase in other genes in the genome". Gene amplification is a widespread phenomenon in eukaryotes. It is an important process in the ...