Osamu Onodera

Profile Information

Affiliation: 所長・教授 (Director， Professor), 脳研究所, 新潟大学

Researcher number: 20303167
ORCID ID: https://orcid.org/0000-0003-3354-5472
J-GLOBAL ID: 200901075757507232
researchmap Member ID: 5000034028

External link: https://scholar.google.co.jp/citations?hl=ja&user=GlabWvwAAAAJ&view_op=list_works

神経疾患の臨床と病態研究をしています

Research Interests

Research Areas

Major Research History

Sep, 2022 - Present

新潟大学医歯学付属病院病院長補佐
Apr, 2020 - Present

Professor, Brain Research Institute Clinical Neuroscience Branch Department of Neurology, Niigata University
Feb, 2020 - Present

Director of Brain Research Institute
Jul, 2020 - Aug, 2022

新潟大学医歯学総合病院副院長
Apr, 2016 - Mar, 2020

Professor, Brain Research Institute Clinical Neuroscience Branch Department of Neurology, Niigata University
Oct, 2010 - Mar, 2016

Brain Research Institute, Niigata University

Education

Apr, 1989 - Mar, 1993

Niigata University
Apr, 1981 - Mar, 1987

Faculty of Medicine, Niigata University

Committee Memberships

Aug, 2018 - Present

Associate Editor, Neurochemistry International
May, 2018 - Present

理事, 日本神経学会
Oct, 2017 - Present

理事, 日本認知症学会

Awards

Nov, 2021

新潟日報文化賞
2009

新潟大学学長表彰, 新潟大学

小野寺理ら
2008

日本神経学会賞, 日本神経学会

小野寺理
2002

ベルツ賞佳作賞

辻省次, 小野寺, 理ら

Major Papers

449

TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models.

Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno

Acta neuropathologica, Aug 9, 2023
Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.

Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Ramil Gabdulkhaev, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka …

Proceedings of the National Academy of Sciences of the United States of America, 120(23) e2214652120, Jun 6, 2023
Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model.

Taisuke Kato, Ri-Ichiroh Manabe, Hironaka Igarashi, Fuyuki Kametani, Sachiko Hirokawa, Yumi Sekine, Natsumi Fujita, Satoshi Saito, Yusuke Kawashima, Yuya Hatano …

The Journal of clinical investigation, 131(22), Nov 15, 2021 Peer-reviewed
Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex.

Yuka Koike, Akihiro Sugai, Norikazu Hara, Junko Ito, Akio Yokoseki, Tomohiko Ishihara, Takuma Yamagishi, Shintaro Tsuboguchi, Mari Tada, Takeshi Ikeuchi …

Communications biology, 4(1) 1107-1107, Sep 21, 2021
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons.

Seiichi Nagano, Junki Jinno, Rehab F Abdelhamid, Yinshi Jin, Megumi Shibata, Shohei Watanabe, Sachiko Hirokawa, Masatoyo Nishizawa, Kenji Sakimura, Osamu Onodera …

Acta neuropathologica, 140(5) 695-713, Nov, 2020 Peer-reviewed
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.

Mercedes Prudencio, Hector Garcia-Moreno, Karen R Jansen-West, Rana Hanna Al-Shaikh, Tania F Gendron, Michael G Heckman, Matthew R Spiegel, Yari Carlomagno, Lillian M Daughrity, Yuping Song …

Science translational medicine, 12(566), Oct 21, 2020 Peer-reviewed
Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation.

Eiko N Minakawa, Helena Akiko Popiel, Masayoshi Tada, Toshiaki Takahashi, Hiroshi Yamane, Yuji Saitoh, Yasuo Takahashi, Daisaku Ozawa, Akiko Takeda, Toshihide Takeuchi …

Brain : a journal of neurology, 143(6) 1811-1825, Jun 1, 2020 Peer-reviewed
Effect of rovatirelin in patients with cerebellar ataxia: two randomised double-blind placebo-controlled phase 3 trials.

Masatoyo Nishizawa, Osamu Onodera, Akihiro Hirakawa, Yoshitaka Shimizu, Masayuki Yamada

Journal of neurology, neurosurgery, and psychiatry, 91(3) 254-262, Mar, 2020 Peer-reviewed
Amyotrophic Lateral Sclerosis with Pallidonigroluysian Degeneration: A Clinicopathological Study.

Junko Ito, Hiroshi Shimizu, Kentaro Ohta, Jiro Idezuka, Hajime Tanaka, Hiroshi Kondo, Takashi Nakajima, Hitoshi Takahashi, Kohei Akazawa, Osamu Onodera …

Annals of neurology, 87(2) 302-312, Feb, 2020 Peer-reviewed
HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature.

Masahiro Uemura, Hiroaki Nozaki, Taisuke Kato, Akihide Koyama, Naoko Sakai, Shoichiro Ando, Masato Kanazawa, Nozomi Hishikawa, Yoshinori Nishimoto, Kiran Polavarapu …

Frontiers in neurology, 11 545-545, 2020 Peer-reviewed
Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation.

Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike, Takuya Konno, Tomohiko Ishihara, Osamu Onodera

Neurobiology of disease, 130 104534-104534, Oct, 2019 Peer-reviewed
Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation.

Rie Saito, Hiroaki Nozaki, Taisuke Kato, Yasuko Toyoshima, Hajime Tanaka, Yutaka Tsubata, Tetsuo Morioka, Yoh Horikawa, Kiyomitsu Oyanagi, Takashi Morita …

Journal of neuropathology and experimental neurology, 78(2) 181-186, Feb 1, 2019 Peer-reviewed
HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade.

Masahiro Uemura, Hiroaki Nozaki, Akihide Koyama, Naoko Sakai, Shoichiro Ando, Masato Kanazawa, Taisuke Kato, Osamu Onodera

Frontiers in neurology, 10 693-693, 2019 Peer-reviewed
Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on in Silico Data.

Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike, Sou Kasahara, Takuya Konno, Tomohiko Ishihara, Osamu Onodera

Frontiers in neuroscience, 12 28-28, 2018 Peer-reviewed
Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

Akihide Koyama, Akihiro Sugai, Taisuke Kato, Tomohiko Ishihara, Atsushi Shiga, Yasuko Toyoshima, Misaki Koyama, Takuya Konno, Sachiko Hirokawa, Akio Yokoseki …

NUCLEIC ACIDS RESEARCH, 44(12) 5820-5836, Jul, 2016 Peer-reviewed
Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.

Hiroaki Nozaki, Taisuke Kato, Megumi Nihonmatsu, Yohei Saito, Ikuko Mizuta, Tomoko Noda, Ryoko Koike, Kazuhide Miyazaki, Muichi Kaito, Shoichi Ito …

Neurology, 86(21) 1964-74, May 24, 2016 Peer-reviewed
Characteristic features and progression of abnormalities on MRI for CARASIL

Hiroaki Nozaki, Yumi Sekine, Toshio Fukutake, Yoshinori Nishimoto, Yutaka Shimoe, Akiko Shirata, Sohei Yanagawa, Mikio Hirayama, Masato Tamura, Masatoyo Nishizawa …

NEUROLOGY, 85(5) 459-463, Aug, 2015 Peer-reviewed
Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis

Tomohiko Ishihara, Yuko Ariizumi, Atsushi Shiga, Taisuke Kato, Chun-Feng Tan, Tatsuya Sato, Yukari Miki, Mariko Yokoo, Takeshi Fujino, Akihide Koyama …

HUMAN MOLECULAR GENETICS, 22(20) 4136-4147, Oct, 2013 Peer-reviewed
MRI Features of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Hiroaki Nozaki, Yumi Sekine, Toshio Fukutake, Yoshinori Nishimoto, Mamoru Shibata, Shimoe Yutaka, Akiko Shirata, Sohei Yanagawa, Mikio Hirayama, Kiyomi Yamane …

NEUROLOGY, 80 560-566, Feb, 2013 Peer-reviewedCorresponding author
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta 1 via cleavage of proTGF-beta 1

Atsushi Shiga, Hiroaki Nozaki, Akio Yokoseki, Megumi Nihonmatsu, Hirotoshi Kawata, Taisuke Kato, Akihide Koyama, Kunimasa Arima, Mari Ikeda, Shinichi Katada …

HUMAN MOLECULAR GENETICS, 20(9) 1800-1810, May, 2011 Peer-reviewed
Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia

Akio Yokoseki, Tomohiko Ishihara, Akihide Koyama, Atsushi Shiga, Mitsunori Yamada, Chieko Suzuki, Yoshiki Sekijima, Kyoko Maruta, Miyuki Tsuchiya, Hidetoshi Date …

BRAIN, 134(Pt 5) 1387-1399, May, 2011 Peer-reviewed
Polyglutamine Diseases: Where does Toxicity Come from? What is Toxicity? Where are We Going?

Toshiaki Takahashi, Shinichi Katada, Osamu Onodera

JOURNAL OF MOLECULAR CELL BIOLOGY, 2(4) 180-191, Aug, 2010 Peer-reviewed
Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

Kenju Hara, Atsushi Shiga, Toshio Fukutake, Hiroaki Nozaki, Akinori Miyashita, Akio Yokoseki, Hirotoshi Kawata, Akihide Koyama, Kunimasa Arima, Toshiaki Takahashi …

NEW ENGLAND JOURNAL OF MEDICINE, 360(17) 1729-1739, Apr, 2009 Peer-reviewed
TDP-43 mutation in familial amyotrophic lateral sclerosis

Akio Yokoseki, Atsushi Shiga, Chun-Feng Tan, Asako Tagawa, Hiroyuki Kaneko, Akihide Koyama, Hiroto Eguchi, Akira Tsujino, Takeshi Ikeuchi, Akiyoshi Kakita …

ANNALS OF NEUROLOGY, 63(4) 538-542, Apr, 2008 Peer-reviewed
Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

Toshiaki Takahashi, Shinya Kikuchi, Shinichi Katada, Yoshitaka Nagai, Masatoyo Nishizawa, Osamu Onodera

HUMAN MOLECULAR GENETICS, 17(3) 345-356, Feb, 2008 Peer-reviewed
Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3 '-phosphate and 3 '-phosphoglycolate ends

Tetsuya Takahashi, Masayoshi Tada, Shuichi Igarashi, Akihide Koyama, Hidetoshi Date, Akio Yokoseki, Atsushi Shiga, Yutaka Yoshida, Shoji Tsuji, Masatoyo Nishizawa …

NUCLEIC ACIDS RESEARCH, 35(11) 3797-3809, Jun, 2007 Peer-reviewed
Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy

Mari Tada, Osamu Onodera, Masayoshi Tada, Tetsutaro Ozawa, Yue-Shan Piao, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa

ARCHIVES OF NEUROLOGY, 64(2) 256-260, Feb, 2007 Peer-reviewed
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

H Date, O Onodera, H Tanaka, K Iwabuchi, K Uekawa, S Igarashi, R Koike, T Hiroi, T Yuasa, Y Awaya …

NATURE GENETICS, 29(2) 184-188, Oct, 2001 Peer-reviewed
Progressive atrophy of cerebellum and brainstem as a function of age and the size of the expanded CAG repeats in the MJD1 gene in Machado-Joseph disease

O Onodera, J Idezuka, S Igarashi, Y Takiyama, K Endo, H Takano, M Oyake, H Tanaka, T Inuzuka, T Hayashi …

ANNALS OF NEUROLOGY, 43(3) 288-296, Mar, 1998 Peer-reviewed
Somatic mosaicism of expanded CAG repeats in brains of patients with dentatorubral-pallidoluysian atrophy: Cellular population-dependent dynamics of mitotic instability

H Takano, O Onodera, H Takahashi, S Igarashi, M Yamada, M Oyake, T Ikeuci, R Koide, H Tanaka, K Iwabuchi …

AMERICAN JOURNAL OF HUMAN GENETICS, 58(6) 1212-1222, Jun, 1996 Peer-reviewed
MOLECULAR-CLONING OF A FULL-LENGTH CDNA FOR DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY AND REGIONAL EXPRESSIONS OF THE EXPANDED ALLELES IN THE CNS

O ONODERA, M OYAKE, H TAKANO, T IKEUCHI, S IGARASHI, S TSUJI

AMERICAN JOURNAL OF HUMAN GENETICS, 57(5) 1050-1060, Nov, 1995 Peer-reviewed
GENETIC ASSOCIATION OF THE VERY-LOW-DENSITY LIPOPROTEIN (VLDL) RECEPTOR GENE WITH SPORADIC ALZHEIMERS-DISEASE

K OKUIZUMI, O ONODERA, Y NAMBA, K IKEDA, T YAMAMOTO, K SEKI, A UEKI, S NANKO, H TANAKA, H TAKAHASHI …

NATURE GENETICS, 11(2) 207-209, Oct, 1995 Peer-reviewed
UNSTABLE EXPANSION OF CAG REPEAT IN HEREDITARY DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY (DRPLA)

R KOIDE, T IKEUCHI, O ONODERA, H TANAKA, S IGARASHI, K ENDO, H TAKAHASHI, R KONDO, A ISHIKAWA, T HAYASHI …

NATURE GENETICS, 6(1) 9-13, Jan, 1994 Peer-reviewed

Misc.

858

研究手法 MOVA:AlphaFold2によるミスセンスバリアントの効果予測

畠野雄也, 畠野雄也, 石原智彦, 小野寺理

遺伝子医学, 14(1), 2024
TDP-43 differentially propagates to induce degeneration in the motor circuit

坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理 …

Dementia Japan, 37(4), 2023
TDP-43変異型により異なる病態進展特性の解析

森秀樹, 坪口晋太朗, 佐藤時春, 中村由香, 加藤泰介, 須貝章弘, 小野寺理, 上野将紀

Dementia Japan, 37(4), 2023
脳血管造影検査後の発熱・意識障害で診断された神経核内封入体病(NIID)の一例

小出伸, 坪口晋太朗, 二宮格, 齋藤太希, 石黒敬信, 佐治越爾, 鈴木倫明, 金澤雅人, 小野寺理

臨床神経学(Web), 63(3), 2023
初期にCastleman病が疑われ特徴的な神経伝導検査所見を呈した61歳男性例

畠山祐樹, 坪口晋太朗, 石黒敬信, 佐治越爾, 細島康宏, 片桐隆幸, 金澤雅人, 小野寺理

臨床神経学(Web), 63(4), 2023
CSF1R関連白質脳症:部分欠失を含む新規CSF1R変異の同定と臨床・画像的特徴

石黒敬信, 今野卓哉, 原範和, 朱斌, 岡田聡, 柴田護, 雑賀玲子, 北野貴也, 祢津智久, 浜由香 …

日本神経学会学術大会プログラム・抄録集, 64th, 2023
Long insular artery梗塞の臨床的検討と冠状断画像の有用性

羽入龍太郎, 坪口晋太朗, 二宮格, 石黒敬信, 今野卓哉, 金澤雅人, 小野寺理

日本神経学会学術大会プログラム・抄録集, 64th, 2023
血漿ニューロフィラメント軽鎖と脳脊髄液バイオマーカーの臨床的有用性の検討

春日健作, 月江珠緒, 五十嵐一也, 五十嵐一也, 石黒敬信, 徳武孝允, 小野寺理, 池内健

日本神経学会学術大会プログラム・抄録集, 64th, 2023
脳生検症例における診断と予後についての後方視的検討

木崎利哉, 石黒敬信, 棗田学, 大石誠, 柿田明美, 藤井幸彦, 小野寺理, 金澤雅人

日本神経学会学術大会プログラム・抄録集, 64th, 2023
脳脊髄液中CEA測定を行った髄膜癌腫症9例の検討

渡邉緑, 石黒敬信, 庄子聡, 金澤雅人, 小野寺理

日本神経学会学術大会プログラム・抄録集, 64th, 2023
ポリグルタミン病治療に向けた次の10年に向けて

小野寺理

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 16回 62-62, Jul, 2022
【神経核内封入体病・白質脳症】HTRA1遺伝子変異に関連する脳小血管病

北原匠, 加藤泰介, 小野寺理

脳神経内科, 97(1) 71-73, Jul, 2022
【神経核内封入体病・白質脳症】HDLS(hereditary diffuse leukoencephalopathy with spheroids)

今野卓哉, 池内健, 小野寺理

脳神経内科, 97(1) 101-109, Jul, 2022
細胞内環境に応じて変形しゲノム編集分子を高効率に送達可能な変幻自在ポリマー

東大志, 田原春徹, 木原拓也, 小野寺理沙子, 本山敬一

日本DDS学会学術集会プログラム予稿集, 38回 95-95, Jun, 2022
組織選択的環状オリゴ糖のニーマン・ピック病C型に対する脂質蓄積改善効果

本山敬一, 西田拓実, 横山龍馬, 竹尾透, 中潟直己, 石塚洋一, 近藤悠希, 入江徹美, 小野寺理沙子, 東大志

日本DDS学会学術集会プログラム予稿集, 38回 98-98, Jun, 2022
家族性アルツハイマー病に対するshRNAポリプレックスの多段階治療戦略

井上雅理, 城野博史, 齊藤貴志, 小野寺理沙子, 東大志, 本山敬一

日本DDS学会学術集会プログラム予稿集, 38回 127-127, Jun, 2022
全身性疾患に伴う脊椎病変頸椎除圧術後の上肢型筋萎縮側索硬化症の臨床経過

五十嵐哲也, 渡辺慶, 大橋正幸, 川島寛之, 三瓶一弘, 五十嵐修一, 黒羽泰子, 小池亮子, 石原智彦, 大津裕 …

東北整形災害外科学会雑誌, 65(1) 167-168, Jun, 2022
一般消費者を対象としたプエラリア・ミリフィカの消費者向け安全性情報におけるピクトグラム活用の有用性に関するランダム化比較調査

種村菜奈枝, 柿崎真沙子, 小野寺理恵, 千葉剛

日本臨床栄養学会雑誌, 43(1) 20-31, Jun, 2022
臨床医のための神経病理再入門 CARASIL

齋藤理恵, 小野寺理, 柿田明美

Clinical Neuroscience, 40(6) 700-702, Jun, 2022
海綿静脈洞に炎症が波及したリンパ球性下垂体炎の41歳女性例

木村嘉克, 上村昌寛, 森秀樹, 今野卓哉, 金澤雅人, 小野寺理, 岡本浩一郎

臨床神経学, 62(4) 307-307, Apr, 2022

Books and Other Publications

厚生労働科学研究費補助金難治性疾患克服研究事業遺伝性脳小血管病の病態機序の解明と治療法の開発班研究報告書

小野寺, 理

[小野寺理], Mar, 2010
転写障害に注目した神経変性過程の解明

小野寺, 理

[小野寺理], Mar, 2005
アプラタキシン欠損症の臨床遺伝学的検討および病態機序の解明

辻, 省次, 後藤, 順, 小野寺, 理, 小宅, 睦郎

辻省次, Mar, 2004

Professional Memberships

Research Projects

脳小血管の細胞外基質の摂動を起こす細胞群の同定と、その制御機構の解読

科学研究費助成事業基盤研究(A), 基盤研究(A), 日本学術振興会, Apr, 2022 - Mar, 2025

小野寺理, 加藤泰介, 塚田啓道, 齋藤理恵
脊髄運動ニューロン固有のRNA制御プログラムとALS病態の関連

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2019 - Mar, 2023

矢野真人, 小野寺理, 矢野佳芳
Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

ONODERA OSMAU
Tauopathy affecting astrocytes: diversity in the tau pathology and the astrocytic molecular feature

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Takahashi Hitoshi
成人発症白質脳症の実際と有効な医療施策に関する研究班

領域別基盤研究分野における難病の医療水準の向上や患者のQOL向上に資する研究（３００８０２０１）, 厚生労働科学研究費補助金, 2018 - 2020

小野寺理
Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Onodera Osamu
Brain Protein Aging and Dementia Control(International Research Activities Supporting Program)

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Nov, 2015 - Mar, 2019

Sobue Gen, YANAI kazuhiko, TAKASHIMA akihiko, HASEGAWA masato, ONODERA osamu, OKANO hideyuki, SAHARA naruhiko, ADACHI hiroaki, ANDO kanae, AKAMATSU wado, UCHIYAMA keiji, OHTA etsuro, OKADA yohei, ONO masahiro, KAIBUCHI kozo, KATO koichi, SAKAGUCHI suehiro, TAINAKA kazuki, TAKAHASHI ryosuke, TANAKA hiromitsu, NAGAI yoshitaka, HASHIMOTO tadafumi, HASEGAWA takafumi, HAMADA kozo, FUKADA masaki, FUKUDA mitsunori, FURUKAWA yoshiaki, MATSUI hideaki, MIZUTA kotaro, MOCHIZUKI hideki, YAMADA kaoru, MORISHITA hideaki, HISANAGA shinichi
Mechanism of protein aging from the point of turbulence of nucleic acid metabolism or its exclusion mechanism.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019

Onodera Osamu, Kakita Akiyoshi
TGF-βシグナルを標的にしたCARASILの新規治療シーズの探索

希少難治性疾患に対する画期的な医薬品医療機器等の実用化に関する研究：薬事承認を目指すシーズ探索研究（ステップ0）, 日本医療研究開発機構研究費, 2017 - 2019

小野寺理
ゲノム編集を用いた優性遺伝性中枢神経疾患の治療方法の開発

【IRUD Beyond+ゲノム編集】希少難治性疾患・未診断疾患領域における革新的開発候補物の非臨床POC確立を目指す研究, 日本医療研究開発機構研究費, 2017 - 2019

小野寺理
ポリグルタミン病に対する蛋白質凝集阻害薬の開発（大阪大学B-49）

シーズB, 医療研究開発推進事業費補助金, 2017 - 2019

小野寺理
重合体形成阻害を標的としたポリグルタミン病の新規治療法開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2016 - Mar, 2018

他田正義, 小野寺理
Elucidation of the significance of MAPT polymorphism associated with sporadic tauopathies by using genome editing method.

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Onodera Osamu
Crosstalk between stress granules and autophagy in protein degradation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Fujii Masahiro, Komatsu Masaaki, Takahashi Masahiko, Kageyama Shun, Hara Toshifumi, Higuchi Masaya, Saito Kousuke, Koyama Akihide, Katsuragi Yoshinori, Kakihana Taichi
Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Takahashi Hitoshi, KAKITA Akiyoshi, SAKIMURA Kenji, IKEUCHI Takeshi
成人発症白質脳症の医療基盤に関する調査研究班

領域別基盤研究分野（客観的な指標に基づく疾病概念が確立されている疾病が対象）（２８０８０４０１）, 厚生労働科学研究費補助金, 2016 - 2017

小野寺理
Heterogeneity of TDP-43 pathology and clinicopathologic correlations in sporadic amyotrophic lateral sclerosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

TAKAHASHI Hitoshi, TOYOSHIMA Yasuko, TADA Mari, ONODERA Osamu
Establishment of TDP-43 C-terminal deficient mice using zinc finger nuclease and application to the model for amyotrophic lateral sclerosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

SATO TOSHIYA, KODERA YOSHIO, ONODERA OSAMU
Approach to cerebral small vessel disease: lesson from CARASIL.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Onodera Osamu, SATO Toshiya, TOYOSHIMA Yasuko, KOYAMA Akihide
Identification of splicing factors that bind to expanded GGGGCC repeat and TDP-43 mRNA

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Onodera Osamu

Industrial Property Rights

特許第5737721号 HTRA1変異と家族性虚血性脳小血管病との関連

辻省次, 小野寺理
特表2012-523819 HTRA1変異と家族性虚血性脳小血管病との関連

辻省次, 小野寺理

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