論文

査読有り
2014年5月

ortho-Allylation of 1-Arylpyrazoles with Allyl Phenyl Ether via Iron-Catalyzed C-H Bond Activation under Mild Conditions

ADVANCED SYNTHESIS & CATALYSIS
  • Sobi Asako
  • ,
  • Jakob Norinder
  • ,
  • Laurean Ilies
  • ,
  • Naohiko Yoshikai
  • ,
  • Eiichi Nakamura

356
7
開始ページ
1481
終了ページ
1485
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/adsc.201400063
出版者・発行元
WILEY-V C H VERLAG GMBH

An iron salt and a bipyridine-type ligand catalyze the ortho-allylation of 1-arylpyrazoles and congeners with allyl phenyl ether under mild conditions (0 degrees C). The ligand, an organozinc base, and the nature of the allylating reagent are crucial for the success of this reaction. Under these conditions, a competitive phenylation reaction is largely retarded, and cross-coupling of the organozinc with the allyl electrophile is minimized. The reaction may proceed via iron-catalyzed ortho CH activation to form a metallic intermediate, which then reacts with the allyl ether in a selective fashion.

Web of Science ® 被引用回数 : 39

リンク情報
DOI
https://doi.org/10.1002/adsc.201400063
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000336505000007&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-4525-5317

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