論文

査読有り 国際誌
2020年4月

Diagnostic Value of FDG-PET/CT for the Identification of Extranodal Extension in Patients With Head and Neck Squamous Cell Carcinoma.

Anticancer research
  • Ryo Toya
  • ,
  • Tetsuo Saito
  • ,
  • Tomohiko Matsuyama
  • ,
  • Yudai Kai
  • ,
  • Shinya Shiraishi
  • ,
  • Daizo Murakami
  • ,
  • Ryoji Yoshida
  • ,
  • Takahiro Watakabe
  • ,
  • Fumi Sakamoto
  • ,
  • Noriko Tsuda
  • ,
  • Hidetaka Arimura
  • ,
  • Yorihisa Orita
  • ,
  • Hideki Nakayama
  • ,
  • Natsuo Oya

40
4
開始ページ
2073
終了ページ
2077
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.21873/anticanres.14165

BACKGROUND/AIM: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. RESULTS: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cut-off of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. CONCLUSION: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE.

リンク情報
DOI
https://doi.org/10.21873/anticanres.14165
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32234899

エクスポート
BibTeX RIS