Apr, 2020
Diagnostic value of FDG-PET/CT for the identification of extranodal extension in patients with head and neck squamous cell carcinoma
Anticancer Research
- Volume
- 40
- Number
- 4
- First page
- 2073
- Last page
- 2077
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.21873/anticanres.14165
Background/Aim: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. Results: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cutoff of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. Conclusion: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE.
- Link information
-
- DOI
- https://doi.org/10.21873/anticanres.14165
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/32234899
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85082731445&origin=inward Open access
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85082731445&origin=inward
- ID information
-
- DOI : 10.21873/anticanres.14165
- ISSN : 0250-7005
- eISSN : 1791-7530
- Pubmed ID : 32234899
- SCOPUS ID : 85082731445