論文

査読有り 国際誌
2020年5月27日

Hypofractionated palliative volumetric modulated arc radiotherapy with the Radiation Oncology Study Group 8502 "QUAD shot" regimen for incurable head and neck cancer.

Radiation oncology (London, England)
  • Ryo Toya
  • ,
  • Tetsuo Saito
  • ,
  • Kohsei Yamaguchi
  • ,
  • Tomohiko Matsuyama
  • ,
  • Takahiro Watakabe
  • ,
  • Tadashi Matsumoto
  • ,
  • Ryoji Yoshida
  • ,
  • Akiyuki Hirosue
  • ,
  • Daizo Murakami
  • ,
  • Yorihisa Orita
  • ,
  • Hideki Nakayama
  • ,
  • Natsuo Oya

15
1
開始ページ
123
終了ページ
123
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s13014-020-01548-w

BACKGROUND: To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 "QUAD shot" regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC). METHODS: Thirty-four consecutive patients with HNC were treated with at least one cycle of the RTOG 8502 regimen. Treatment plans included the use of VMAT with 6 MV photons generated by a linear accelerator. Two daily fractions of 3.7 Gy were delivered with an interval of at least 6 h for 2 consecutive days, totaling 14.8 Gy over 4 fractions. This was repeated every 3-4 weeks for a total of three cycles. No concurrent systemic therapy was performed. RESULTS: The number of completed cycles was 1 in 6 (18%) patients, 2 in 5 (15%), and 3 in 23 (68%). Tumor response was achieved in 29 (85%) patients and symptom relief in 20 (77%) of 26 patients. Overall response (tumor response or symptom relief) was achieved in 32 (94%) patients. All patients who received 2 or more treatment cycles achieved overall response. Median overall survival (OS) was 5.7 months. Multivariate analysis revealed that completion of all three treatment cycles was significantly associated with better OS (P = 0.002). Grade 2 toxicity was observed in four (12%) patients, but no acute Grade ≥ 3 or late toxicity was observed. CONCLUSIONS: The RTOG 8502 "QUAD shot" regimen using VMAT is effective for incurable HNC with highly reduced toxicity. Treatment with multiple cycles is recommended for better treatment response and/or survival.

リンク情報
DOI
https://doi.org/10.1186/s13014-020-01548-w
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32460865

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