論文

査読有り 国際誌
2019年2月

Sox13 is a novel early marker for hair follicle development

Biochemical and Biophysical Research Communications
  • Mai Noto
  • ,
  • Natsuko Noguchi
  • ,
  • Akihiko Ishimura
  • ,
  • Hiroshi Kiyonari
  • ,
  • Takaya Abe
  • ,
  • Tomoko Suzuki
  • ,
  • Naoko Hasunuma
  • ,
  • Masanori Taira
  • ,
  • Motomu Manabe
  • ,
  • Shin-Ichi Osada

509
4
開始ページ
862
終了ページ
868
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2018.12.163
出版者・発行元
Elsevier {BV}

Sox13, a group D member of the Sry-related high-mobility group box (Sox) transcription factor family, is expressed in various tissues including the hair follicle. However, its spatiotemporal expression patterns in the hair follicle and its role in hair development remain to be elucidated. To address these questions, we generated Sox13-LacZ-knock-in mice (Sox13LacZ/+), in which the LacZ reporter gene was inserted in-frame into exon 2, which contains the translation initiation codon. X-gal staining in Sox13LacZ/+ embryos revealed that Sox13 is initially expressed in the epithelial portion of the placode, and subsequently in the hair germ and the hair peg during early hair follicle development. In postnatal catagen and anagen, Sox13 was detected in the epithelial sheath, whereas in telogen, Sox13 was localized in the bulge region, where hair follicle stem cells reside. Immunohistochemistry with an anti-β-galactosidase antibody and anti-hair keratin antibodies that specifically mark the different layers of the hair follicle revealed that Sox13 was predominantly expressed in the outer root sheath in anagen. However, the integumentary structures of Sox13LacZ/LacZ mice were grossly and histologically indistinguishable from those of wild type mice. These results suggest that although Sox13 is dispensable for epidermal and adnexal development, Sox13 is a useful marker for early hair follicle development.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2018.12.163
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30638933
ID情報
  • DOI : 10.1016/j.bbrc.2018.12.163
  • ORCIDのPut Code : 52530287
  • PubMed ID : 30638933

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