論文

査読有り 国際誌
2020年10月16日

Effect of monoterpene ester from Blumea axillaris (Lam.) DC and its acetyl derivative against plant pathogenic fungi and their in silico molecular docking.

Natural product research
  • Subramaniyan Sivanandhan
  • ,
  • Ganesan Pathalam
  • ,
  • Stalin Antony
  • ,
  • Gabriel Paulraj Michael
  • ,
  • Kedike Balakrishna
  • ,
  • Ahilan Boovaragamurthy
  • ,
  • Osamu Shirota
  • ,
  • Mona S Alwahibi
  • ,
  • Mohamed Soliman El-Shikh
  • ,
  • Savarimuthu Ignacimuthu

35
24
開始ページ
1
終了ページ
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/14786419.2020.1833197
出版者・発行元
TAYLOR & FRANCIS LTD

The present study was aimed to isolate active constituents from Blumea axillaris (Lam.) DC (Asteraceae) against phytopathogenic fungi. Bioactivity guided fractionation of the successive n-hexane, chloroform and methanol extract led to the isolation of the monoterpene ester (4 R,5S)-4-hydroxy-7-tigloyloxycarvotanacetone (1). The compound 1 was converted into acetyl derivative (2). The acetyl derivative (2) and the parent compound 1 were tested again phytopathogenic fungi by using mycelial inhibition and minimal inhibitory concentration values were found out by the broth microdilution method. The acetyl derivative (2) showed the highest antifungal activity against Rhizoctonia solani and Aspergillus niger. Based upon in vitro results, compound 1 was tested against Fusarium oxyporum (wilting disease) and compound 2 was tested against R. solani (leaf blight disease) in vivo using the foliar spray method. Both compounds had no phytotoxicity and also in silico docking study showed that both compounds were binding similarly as commercial fungicide carbendazim.

リンク情報
DOI
https://doi.org/10.1080/14786419.2020.1833197
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33059480
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000577679900001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1080/14786419.2020.1833197
  • ISSN : 1478-6419
  • eISSN : 1478-6427
  • PubMed ID : 33059480
  • Web of Science ID : WOS:000577679900001

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