Apr, 2013 - Mar, 2015
Development of novel fracture healing methods using artificical perioteum and collagen-binding growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
- Grant number
- 25670659
- Japan Grant Number (JGN)
- JP25670659
- Grant amount
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- (Total)
- 3,770,000 Japanese Yen
- (Direct funding)
- 2,900,000 Japanese Yen
- (Indirect funding)
- 870,000 Japanese Yen
We attempted to develop a functional artificial periosteum using mesenchymal stem cells (MSCs) and a fusion protein (collagen binding-bFGF, CB-bFGF) consisting of bFGF and the collagen-binding domain (CBD) of Clostridium histolyticum collagenase for bone repair. Artificial periosteum had higher expression of trophic factots than monolayer cultured MSCs. Moreover, the combination of the collage CB-bFGF with artificial periosteum induced bone formation compared to artificial periosteum alone in rat models. Taken together, these properties suggest that the CB-bFGF/artificial periosteum composite is a promising material for bone repair in the clinical setting.
- Link information
- ID information
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- Grant number : 25670659
- Japan Grant Number (JGN) : JP25670659