MISC

査読有り 本文へのリンクあり
2011年

Functional characterization of protein domains common to animal viruses and mouse

10th Int. Conference on Bioinformatics - 1st ISCB Asia Joint Conference 2011, InCoB 2011/ISCB-Asia 2011: Computational Biology - Proceedings from Asia Pacific Bioinformatics Network (APBioNet)
  • Akira R. Kinjo
  • ,
  • Yutaro Kumagai
  • ,
  • Huy Dinh
  • ,
  • Osamu Takeuchi
  • ,
  • Daron M. Standley

12
SUPPL. 3
記述言語
英語
掲載種別
DOI
10.1186/1471-2164-12-S3-S21
出版者・発行元
BIOMED CENTRAL LTD

Background: Many viruses contain genes that originate from their hosts. Some of these acquired genes give viruses the ability to interfere with host immune responses by various mechanisms. Genes of host origin that appear commonly in viruses code for proteins that span a wide range of functions, from kinases and phosphotases, to cytokines and their receptors, to ubiquitin ligases and proteases. While many important cases of such lateral gene transfer in viruses have been documented, there has yet to be a genome-wide survey of viralencoded genes acquired from animal hosts. Results: Here we carry out such a survey in order to gain insight into the host immune system. We made the results available in the form of a web-based tool that allows viral-centered or host-centered queries to be performed (http://imm.ifrec.osaka-u.ac.jp/musvirus/) . We examine the relationship between acquired genes and immune function, and compare host-virus homology with gene expression data in stimulated dendritic cells and T-cells. We found that genes whose expression changes significantly during the innate antiviral immune response had more homologs in animal virus than genes whose expression did not change or genes involved in the adaptive immune response. Conclusions: Statistics gathered from the MusVirus database support earlier reports of gene transfer from host to virus and indicate that viruses are more likely to acquire genes involved in innate antiviral immune responses than those involved in acquired immune responses. © 2011 licensee BioMed Central Ltd.

リンク情報
DOI
https://doi.org/10.1186/1471-2164-12-S3-S21
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22369715
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000303447900001&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862243097&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84862243097&origin=inward
ID情報
  • DOI : 10.1186/1471-2164-12-S3-S21
  • ISSN : 1471-2164
  • PubMed ID : 22369715
  • SCOPUS ID : 84862243097
  • Web of Science ID : WOS:000303447900001

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