2013年6月1日
Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation
Journal of Immunology
- 巻
- 190
- 号
- 11
- 開始ページ
- 5702
- 終了ページ
- 5711
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.4049/jimmunol.1203155
- 出版者・発行元
- AMER ASSOC IMMUNOLOGISTS
TNFR-associated factor family member-associated NF-κB activator (TANK)-binding kinase 1 (TBK1) is critical for the activation of IFN regulatory factor 3 and type I IFN production upon virus infection. A set of TBK1-binding proteins, 5-azacytidine-induced gene 2 (AZI2; also known as NAP1), TANK, and TBK1-binding protein 1 (TBKBP1), have also been implicated in the production of type I IFNs. Among them, TANK was found to be dispensable for the responses against virus infection. However, physiological roles of AZI2 and TBKBP1 have yet to be clarified. In this study, we found that none of these TBK1-binding proteins is critical for type I IFN production in mice. In contrast, AZI2, but not TBKBP1, is critical for the differentiation of conventional dendritic cells (cDCs) from bone marrow cells in response to GM-CSF. AZI2 controls GM-CSF-induced cell cycling of bone marrow cells via TBK1. GM-CSF-derived DCs from AZI2-deficient mice show severe defects in cytokine production and T cell activation both in vitro and in vivo. Reciprocally, overexpression of AZI2 results in efficient generation of cDCs, and the cells show enhanced T cell activation in response to Ag stimulation. Taken together, AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs. Copyright © 2013 by The American Association of Immunologists, Inc.
- リンク情報
-
- DOI
- https://doi.org/10.4049/jimmunol.1203155
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/23610142
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000319205900040&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878035924&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84878035924&origin=inward
- ID情報
-
- DOI : 10.4049/jimmunol.1203155
- ISSN : 0022-1767
- eISSN : 1550-6606
- PubMed ID : 23610142
- SCOPUS ID : 84878035924
- Web of Science ID : WOS:000319205900040