2004年2月
Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium
Immunology
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- 巻
- 111
- 号
- 2
- 開始ページ
- 179
- 終了ページ
- 185
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.0019-2805.2003.01807.x
- 出版者・発行元
- BLACKWELL PUBLISHING LTD
The role of the Toll-like receptor (TLR)-2 in the generation of protective immunity to Mycobacterium avium was evaluated using gene-disrupted mice. TLR-2-/- mice were more susceptible than wild-type C57BI/6 mice to M. avium strains that were able to proliferate in vivo before the development of protective immunity and mycobacteriostasis. In contrast, the elimination of non-virulent strains was not affected by the mutation. The generation of interferon-γ (IFN-γ)-producing T cells and the expression of the interleukin-12 p40 gene were reduced in TLR-2-deficient mice as compared to C57BI/6 mice early during infection with M. avium strain 2447. The generation of protective CD4+ T cells was also compromised in the mutated mice as compared with the controls. Our data show that TLR-2 is required for optimal immunity against certain virulent M. avium strains.
- リンク情報
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- DOI
- https://doi.org/10.1111/j.0019-2805.2003.01807.x
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15027903
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000188353900007&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0842265556&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0842265556&origin=inward
- ID情報
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- DOI : 10.1111/j.0019-2805.2003.01807.x
- ISSN : 0019-2805
- PubMed ID : 15027903
- SCOPUS ID : 0842265556
- Web of Science ID : WOS:000188353900007