2005年10月
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Nature Immunology
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- 巻
- 6
- 号
- 10
- 開始ページ
- 981
- 終了ページ
- 988
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ni1243
- 出版者・発行元
- NATURE PUBLISHING GROUP
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon inducers, we have identified here a molecule we call interferon-β promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I interferon and interferon-inducible genes through activation of IRF3, IRF7 and NF-κB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses. © 2005 Nature Publishing Group.
- リンク情報
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- DOI
- https://doi.org/10.1038/ni1243
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902232024513181
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16127453
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000232027200016&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=27144440523&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=27144440523&origin=inward
- ID情報
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- DOI : 10.1038/ni1243
- ISSN : 1529-2908
- J-Global ID : 200902232024513181
- PubMed ID : 16127453
- SCOPUS ID : 27144440523
- Web of Science ID : WOS:000232027200016