2010年
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
Nature Immunology
- 巻
- 11
- 号
- 4
- 開始ページ
- 335
- 終了ページ
- 343
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ni.1847
- 出版者・発行元
- NATURE PUBLISHING GROUP
Here we describe a previously unknown form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra. Mice homozygous for this mutation showed enhanced susceptibility to bacterial and viral infection and diminished numbers of T cells and inflammatory monocytes that failed to proliferate after infection and died via the intrinsic apoptotic pathway in response to diverse proliferative stimuli. They also had a greater proportion of T cells poised to replicate DNA, and their T cells expressed a subset of activation markers, suggestive of a semi-activated state. We positionally ascribe the elektra phenotype to a mutation in the gene encoding Schlafen-2 (Slfn2). Our findings identify a physiological role for Slfn2 in the defense against pathogens through the regulation of quiescence in T cells and monocytes. © 2010 Nature America, Inc. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1038/ni.1847
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20190759
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000275849500013&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77949837209&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=77949837209&origin=inward
- ID情報
-
- DOI : 10.1038/ni.1847
- ISSN : 1529-2908
- eISSN : 1529-2916
- PubMed ID : 20190759
- SCOPUS ID : 77949837209
- Web of Science ID : WOS:000275849500013