Osamu Takeuchi

Profile Information

Affiliation: Graduate School of Medicine, Kyoto University

Degree: 博士（医学）(大阪大学)

Contact information: otakemfour.med.kyoto-u.ac.jp
J-GLOBAL ID: 201201008533281839
researchmap Member ID: B000224947

External link: https://mc.mfour.med.kyoto-u.ac.jp/

Research Interests

Research Areas

Research History

Oct, 2018 - Present

Graduate School of Medicine, Kyoto University
Apr, 2012 - Sep, 2018

Kyoto University
2007 - 2012

Research Institute for Microbial Diseases, Osaka University
Apr, 2004 - Mar, 2007

Research Institute for Microbial Diseases, Osaka University
Apr, 2002 - Mar, 2004

Post doctoral fellow, Harvard University

Education

Apr, 1997 - Mar, 2001

Graduate School of Medicine, Osaka University
Apr, 1989 - Mar, 1995

Medical School, Faculty of Medicine, Osaka University

Awards

Apr, 2023

令和5年度科学技術分野の文部科学大臣表彰科学技術賞（研究部門）, 文部科学省

竹内理
Dec, 2020

第23回日本免疫学会賞

竹内理
Feb, 2016

第 12回日本学士院学術奨励賞

竹内理
Feb, 2016

第 12回日本学術振興会賞

竹内理

Papers

278

TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for TLR-induced cytokine production in macrophages

Tanveer Ali, Huong Minh Nguyen, Naeem Abbas, Osamu Takeuchi, Shizuo Akira, Toshihiko Suzuki, Goro Matsuzaki, Giichi Takaesu

International Immunology, Apr 3, 2024
Regulation of inflammatory diseases via the control of mRNA decay

Masanori Yoshinaga, Osamu Takeuchi

Inflammation and Regeneration, Mar 15, 2024
RNA Metabolism Governs Immune Function and Response.

Masanori Yoshinaga, Osamu Takeuchi

Advances in experimental medicine and biology, 1444 145-161, 2024
Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.

Takuya Uehata, Shinnosuke Yamada, Daisuke Ori, Alexis Vandenbon, Amir Giladi, Adam Jelinski, Yasuhiro Murakawa, Hitomi Watanabe, Kazuhiro Takeuchi, Kazunori Toratani …

Blood, Nov 3, 2023
Regnase-1 plays an essential role in maintaining skin immune homeostasis via regulation of chemokine expression.

Gabsik Yang, Hye Eun Lee, Magdalena Trzeciak, Tadeusz Pawelczyk, Osamu Takeuchi, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 162 114558-114558, Jun, 2023 Peer-reviewed
Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins.

Ka Man Tse, Osamu Takeuchi

Archives of pharmacal research, 46(2) 65-77, Feb, 2023 Peer-reviewedInvitedLast authorCorresponding author
免疫学 RNA分解酵素Regnase-1を標的とした炎症制御法の開発

吉永正憲, 竹内理

医学のあゆみ, 284(2) 152-153, Jan, 2023
The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.

Masanori Yoshinaga, Kyuho Han, David W Morgens, Takuro Horii, Ryosuke Kobayashi, Tatsuaki Tsuruyama, Fabian Hia, Shota Yasukura, Asako Kajiya, Ting Cai …

Nature communications, 13(1) 6435-6435, Oct 28, 2022 Peer-reviewedLast authorCorresponding author
Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.

Ai Yaku, Tadakatsu Inagaki, Ryotaro Asano, Makoto Okazawa, Hiroyoshi Mori, Ayuko Sato, Fabian Hia, Takeshi Masaki, Yusuke Manabe, Tomohiko Ishibashi …

Circulation, 101161CIRCULATIONAHA122059435, Aug 23, 2022 Peer-reviewedLast authorCorresponding author
Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells.

Aki Ejima, Shinya Abe, Akihiro Shimba, Susumu Sato, Takuya Uehata, Shizue Tani-Ichi, Satoru Munakata, Guangwei Cui, Osamu Takeuchi, Toyohiro Hirai …

Journal of immunology (Baltimore, Md. : 1950), 209(6) 1083-1094, Aug 17, 2022 Peer-reviewed
Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases.

Ka Man Tse, Alexis Vandenbon, Xiaotong Cui, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga …

Science translational medicine, 14(644) eabo2137, May 11, 2022 Peer-reviewedLast authorCorresponding author
Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism.

Yee Kien Chong, Sarang Tartey, Yuki Yoshikawa, Koshi Imami, Songling Li, Masanori Yoshinaga, Ai Hirabayashi, Guohao Liu, Alexis Vandenbon, Fabian Hia …

Science signaling, 15(729) eabm5011, Apr 12, 2022 Peer-reviewedLast authorCorresponding author
TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation.

Atsuko Wakabayashi, Masanori Yoshinaga, Osamu Takeuchi

Life science alliance, 5(2), Feb, 2022 Peer-reviewedLast authorCorresponding author
DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex

Kotaro Akaki, Takashi Mino, Osamu Takeuchi

BIO-PROTOCOL, 12(15), 2022 Peer-reviewedInvitedLast authorCorresponding author
Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin.

Yuki Hikichi, Yasutaka Motomura, Osamu Takeuchi, Kazuyo Moro

The Journal of experimental medicine, 218(12), Dec 6, 2021 Peer-reviewed
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay.

Kotaro Akaki, Kosuke Ogata, Yuhei Yamauchi, Noriki Iwai, Ka Man Tse, Fabian Hia, Atsushi Mochizuki, Yasushi Ishihama, Takashi Mino, Osamu Takeuchi

eLife, 10, Oct 12, 2021 Peer-reviewedLast authorCorresponding author
Regnase-1-related endoribonucleases in health and immunological diseases.

Takashi Mino, Osamu Takeuchi

Immunological reviews, Sep 12, 2021 Peer-reviewedInvitedLast authorCorresponding author
Post-transcriptional regulation of immunological responses by Regnase-1-related RNases.

Takuya Uehata, Osamu Takeuchi

International immunology, Jul 28, 2021 Peer-reviewedInvitedLast authorCorresponding author
Extracellular mRNA transported to the nucleus exerts translation-independent function.

Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-Ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi …

Nature communications, 12(1) 3655-3655, Jun 16, 2021 Peer-reviewed
PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.

Ankur Garg, Yvette Roske, Shinnosuke Yamada, Takuya Uehata, Osamu Takeuchi, Udo Heinemann

Nucleic acids research, May 5, 2021 Peer-reviewed

Misc.

Identification of a novel post-transcriptional regulator in erythroid differentiation

吉永正憲, 竹内理

日本分子生物学会年会プログラム・要旨集(Web), 44th, 2021
Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability

Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Akaki Kotaro, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Tomonori Hirano …

CANCER RESEARCH, 80(16), Aug, 2020
特発性肺線維症における2型自然リンパ球の意義に関する包括的検討

中塚賀也, 半田知宏, 渡邉創, 谷澤公伸, 村瀬裕子, 池上直弥, 庭本崇史, 中西智子, 陳和夫, 竹内理 …

日本呼吸器学会誌, 8(増刊) 193-193, Mar, 2019
免疫細胞を制御するRNA結合タンパク質の機能解析

植畑拓也, 山田信之輔, 織大祐, 今見考志, 宮崎正輝, 石濱泰, 河本宏, 竹内理

日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019
生理学・医学賞免疫を抑制する分子"PD-1"とがん免疫療法 (2018年ノーベル賞を読み解く)

吉永正憲, 竹内理

化学 = Chemistry, 73(12) 26-29, Dec, 2018
Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow

Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Hiroshi Kawamoto, Osamu Takeuchi

日本免疫学会学術集会, 2018年度, Dec, 2018
鉄代謝を制御する転写後調節機構の解明

吉永正憲, 三野享史, BASSIK Michael C, 竹内理

日本RNA学会年会要旨集, 20th, 2018
Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

吉永正憲, 三野享史, 竹内理

日本分子生物学会年会プログラム・要旨集(Web), 41st, 2018
RNA分解酵素Regnase-1による鉄代謝制御機構

竹内理, 吉永正憲

日本鉄バイオサイエンス学会学術集会プログラム・抄録集, 42nd, 2018
A型肝炎ウイルスIRES依存的翻訳は肝臓特異的因子により活性化される

貞廣暁利, 深尾亜喜良, 小坂実央, 滝沢直己, 船上仁範, 竹内理, DUNCAN Kent E., 藤原俊伸

日本RNA学会年会要旨集, 20th, 2018
+鎖型一体鎖RNAウイルスの組織特異的IRES依存的翻訳機構の解析

貞廣暁利, 深尾亜喜良, 滝沢直己, 船上仁範, 竹内理, 藤原俊伸

RNAフロンティアミーティング, 2018, 2018
新規RNA分解酵素によるHIV-1感染制御機構の解明

山岨大智, 佐藤佳, 佐藤佳, 小柳義夫, 竹内理

日本生体防御学会学術総会講演抄録集, 29th, 2018
MALT1によるN4BP1の分解は潜伏感染HIV-1の再活性化を促進する

山岨大智, 佐藤佳, 小柳義夫, 竹内理

日本エイズ学会誌, 20(4), 2018
Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity

Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi

CYTOKINE, 100 39-39, Dec, 2017
Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

吉永正憲, 三野享史, 竹内理

日本生化学会大会(Web), 90th, 2017
Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

吉永正憲, 三野享史, 竹内理

日本RNA学会年会要旨集, 19th, 2017
A型肝炎ウイルスの細胞種特異性を生み出す,IRES依存的翻訳制御機構の解析

貞廣暁利, 小坂実央, 深尾亜喜良, 竹内理, 藤原俊伸

日本生化学会大会(Web), 90th, 2017
Poliovirusの組織特異的増殖を生み出すIRES依存的翻訳機構の解明

貞廣暁利, 深尾亜喜良, 竹内理, 藤原俊伸

日本生化学会大会(Web), 90th, 2017
ポリオウイルスの細胞種特異的なIRES依存的翻訳の解析

貞廣暁利, 足達俊吾, 深尾亜喜良, 船上仁範, 夏目徹, 竹内理, 藤原俊伸

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.3LBA‐022 (WEB ONLY), 2016
Arl5BによるMDA5依存的な抗ウイルス自然免疫応答の抑制機構の解明

鍛代悠一, 織大祐, 末吉拓也, 川崎拓実, 竹内理, 松田正, 審良静男, 河合太郎

日本薬学会年会要旨集(CD-ROM), 136th ROMBUNNO.29AB‐AM249, 2016

Presentations

Antiviral innate immunity targeting RNA

Osamu Takeuchi

6th European Congress of Immunology, Sep 1, 2021 Invited
Post-transcriptional control of inflammation-induced immune cell differentiation

Osamu Takeuchi

Jun 29, 2021 Invited
Post-transcriptional regulation of innate immunity by Regnase-1

Osamu Takeuchi

The 27th International Symposium on Molecular Cell Biology of Macrophages (MMCB2020), Jun 15, 2021 Invited
RNA分解による免疫応答の制御機構

竹内理

2020年度東京大学医科学研究所国際共同利用・共同研究拠点成果報告会, Mar 10, 2021 Invited
Regnase-1による免疫調節機構

竹内理

第7回免疫セミナー, Feb 5, 2021 Invited
Immune regulation by translation-dependent mRNA decay

Dec 2, 2020
Manipulation of Regnase-1 mRNA stability alleviates inflammatory responses in diseased models

Tse, K.M, Cui, X, Uehata, T, Takeuchi, O

Invited
RNA代謝による自然免疫応答の惹起と制御

竹内理

日本臨床免疫学会総会, Oct 15, 2020 Invited
Regulatory mechanisms of innate immune responses

Osamu Takeuchi

Oct 8, 2020 Invited

Professional Memberships

Oct, 1998 - Present

Japanese Society for Immunology

Research Projects

ウイルスー人体相互ネットワークの理解と操作

Nov, 2020 - Mar, 2025
Analysis of immune regulatory mechanisms mediated by mRNA metabolism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2023
コドンに隠された暗号の解明：ヒトコドン最適化制御による治療戦略

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, Apr, 2020 - Mar, 2022

竹内理, HIA FABIAN
Control of immune responses via spatiotemporal regulation of mRNA decay

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2019
Study of UPF1-mediated mRNA regulation in immune system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MINO Takashi, TAKEUCHI Osamu
The pathogenic role of Arid5a in infection and autoimmunity.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

MASUDA Kazuya, KISHIMOTO Tadamitsu, TAKEUCHI Osamu
Analysis of the mechanisms of an RNase, Zc3h12a-mediated immune regulation.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, 2010 - 2012

TAKEUCHI Osamu
Comprehensive study of innate immunity

Grants-in-Aid for Scientific Research Grant-in-Aid for Specially Promoted Research, Grant-in-Aid for Specially Promoted Research, Japan Society for the Promotion of Science, 2008 - 2012

AKIRA Shizuo, TAKEUCHI Osamu, KAWAI Taro, SAITOH Tatsuya, SATOH Takashi
自然免疫系によるウイルス特異的分子パターン認識機構の解析

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2005 - 2006

竹内理

Major Industrial Property Rights

特許7258362号 INFLAMMATION-SUPPRESSING COMPOSITION

Osamu Takeuchi

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Presentations

Professional Memberships

Research Projects

Major Industrial Property Rights

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