2022年6月9日
Natural history trajectories of frailty in community-dwelling older Japanese adults.
The journals of gerontology. Series A, Biological sciences and medical sciences
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 77
- 号
- 10
- 開始ページ
- 2059
- 終了ページ
- 2067
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/gerona/glac130
BACKGROUND: The gap between the average life expectancy and healthy life expectancy remains wide. Understanding the natural history of frailty development is necessary to prevent and treat frailty to overcome this gap. This study elucidated the trajectories of five frailty assessment components using group-based multi-trajectory modeling. METHODS: Overall, 845 community-dwelling older adults (aged 65-91 years; 433 males and 412 females) who underwent longitudinal frailty assessments at least three times were included in the analysis. The mean follow-up period (±SD, range) was 7.1 (±2.3, 3.8-11.3) years. In each wave, the physical frailty was assessed for the following five partially modified components of the Cardiovascular Health Study criteria: shrinking, weakness, exhaustion, slowness, and low activity. Using group-based multi-trajectory modeling, we identified subgroups that followed distinctive trajectories regarding the five frailty components. RESULTS: Five frailty trajectory groups were identified: weakness-focused frail progression group (G1; 10.9%), robust maintenance group (G2; 43.7%), exhaustion-focused pre-frail group (G3; 24.3%), frail progression group (G4; 6.7%), and low activity-focused pre-frail group (G5; 14.4%). The Cox proportional hazards model analysis showed that G1, G4, and G5 had significantly higher mortality risks after adjusting for sex and age (G2 was the reference group). CONCLUSIONS: Based on the natural history of frailty, the five distinctive trajectory groups showed that some individuals remained robust, while others remained predominantly pre-frail or progressed primarily owing to physical mobility decline. Therefore, identifying individuals belonging to these progressive frailty groups and providing interventions according to the characteristics of each group may be beneficial.
- リンク情報
-
- DOI
- https://doi.org/10.1093/gerona/glac130
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/35679612
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536447
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139376497&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85139376497&origin=inward
- ID情報
-
- DOI : 10.1093/gerona/glac130
- ISSN : 1079-5006
- eISSN : 1758-535X
- PubMed ID : 35679612
- PubMed Central 記事ID : PMC9536447
- SCOPUS ID : 85139376497