大喜多守 (Mamoru Ohkita) - マイポータル

基本情報

所属: 大阪医科薬科大学病態分子薬理学研究室

学位: 博士（薬学）(2002年3月大阪薬科大学)

J-GLOBAL ID: 201801006326290340
researchmap会員ID: B000332727

研究分野

経歴

2020年4月 - 現在

大阪医科薬科大学, 病態分子薬理学研究室, 教授 (博士（薬学）)

論文

Vasoprotection by Dietary Nitrate in Rats with Vitamin D3-Induced Vascular Calcification

Masashi Tawa, Keisuke Nakagawa, Mamoru Ohkita

Journal of Vascular Diseases 5(1) 3-3 2026年1月20日
Roxadustat has beneficial effects on the vascular tone of the rat thoracic aorta.

Keisuke Nakagawa, Yoriko Oshiba, Reo Sukita, Ayaka Hosomi, Masashi Tawa, Mamoru Ohkita

Journal of cardiovascular pharmacology 2025年4月8日
Soluble guanylate cyclase stimulators and activators as potential antihypertensive drugs.

Masashi Tawa, Keisuke Nakagawa, Mamoru Ohkita

Hypertension research : official journal of the Japanese Society of Hypertension 48(4) 1458-1470 2025年4月
Different sensitivities of porcine coronary arteries and veins to BAY 60-2770, a soluble guanylate cyclase activator.

Masashi Tawa, Keisuke Nakagawa, Mamoru Ohkita

Journal of pharmacological sciences 157(1) 1-7 2025年1月
Efficacy of BAY 60-2770, a Soluble Guanylate Cyclase Activator, for Coronary Spasm in Animal Models.

Masashi Tawa, Keisuke Nakagawa, Mamoru Ohkita

The Journal of pharmacology and experimental therapeutics 390(3) 280-287 2024年8月19日査読有り
Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice.

Masashi Tawa, Keisuke Nakagawa, Mamoru Ohkita

Physiological reports 11(12) e15755 2023年6月査読有り
Ameliorative Effects of Beetroot Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats

Masashi Tawa, Junya Nagano, Junpei Kitama, Shunto Abe, Ako Fujita, Keisuke Nakagawa, Mamoru Ohkita

Future Pharmacology 2(4) 547-557 2022年11月16日査読有り
Soluble Guanylate Cyclase-Mediated Relaxation in Aortas from Rats with Renovascular Hypertension.

Masashi Tawa, Takashi Shimosato, Keisuke Nakagawa, Tomio Okamura, Mamoru Ohkita

Pharmacology 107(3-4) 235-240 2022年査読有り
Acute Kynurenine Exposure of Rat Thoracic Aorta Induces Vascular Dysfunction via Superoxide Anion Production.

Keisuke Nakagawa, Fumika Kobayashi, Yoshiki Kamei, Masashi Tawa, Mamoru Ohkita

Biological & pharmaceutical bulletin 45(4) 522-527 2022年査読有り
Vascular Endothelial Dysfunction in the Thoracic Aorta of Rats with Ischemic Acute Kidney Injury: Contribution of Indoxyl Sulfate.

Keisuke Nakagawa, Ryosuke Tanaka, Masahide Donouchi, Masaya Kanda, Saaya Kamada, Shuhei Kobuchi, Masashi Tawa, Yasuo Matsumura, Mamoru Ohkita

Oxidative medicine and cellular longevity 2022 7547269-7547269 2022年査読有り
Indoxyl sulfate induces ROS production via the aryl hydrocarbon receptor-NADPH oxidase pathway and inactivates NO in vascular tissues.

Keisuke Nakagawa, Mayuko Itoya, Nao Takemoto, Yuika Matsuura, Masashi Tawa, Yasuo Matsumura, Mamoru Ohkita

Life sciences 265 118807-118807 2021年1月15日査読有り
Preventive effects of nitrate-rich beetroot juice supplementation on monocrotaline-induced pulmonary hypertension in rats.

Masashi Tawa, Rikako Nagata, Yuiko Sumi, Keisuke Nakagawa, Tatsuya Sawano, Mamoru Ohkita, Yasuo Matsumura

PloS one 16(4) e0249816 2021年査読有り
Grape Extract from Chardonnay Seeds Restores Deoxycorticosterone Acetate-Salt-Induced Endothelial Dysfunction and Hypertension in Rats.

Akihiro Sato, Satoshi Nishioka, Mika Kiuchi, Yuki Imada, Kotaro Makino, Keisuke Nakagawa, Ryosuke Tanaka, Yasuo Matsumura, Mamoru Ohkita

Biological & pharmaceutical bulletin 43(1) 59-67 2020年査読有り
Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation.

Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Chinthika Gunasekara, Yuki Anbe, Yuichi Hiraoka, Jun Liu, Helmut Grasberger, Mamoru Ohkita, Yasuo Matsumura …

Journal of immunology (Baltimore, Md. : 1950) 202(9) 2546-2557 2019年5月1日査読有り
Preventive Effects of Grape Extract on Ischemia/Reperfusion-Induced Acute Kidney Injury in Mice.

Mamoru Ohkita, Haruna Hayashi, Kohei Ito, Natsuko Shigematsu, Ryosuke Tanaka, Hidenobu Tsutsui, Yasuo Matsumura

Biological & pharmaceutical bulletin 42(11) 1883-1890 2019年査読有り
Involvement of γ-Glutamyl Transpeptidase in Ischemia/Reperfusion-Induced Cardiac Dysfunction in Isolated Rat Hearts

Koyama, T, Tsubota, A, Sawano, T, Tawa, M, Watanabe, B, Hiratake, J, Nakagawa, K, Matsumura, Y, Ohkita, M

Biol. Pharm. Bull. 42(11) 1947-1952 2019年査読有り
Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.

Tawa M, Yano Y, Yamanaka M, Sawano T, Iesaki K, Murata Y, Tanaka R, Nakagawa K, Ohkita M, Matsumura Y

American journal of hypertension 32(2) 216-222 2018年9月査読有り
Stimulation of nitric oxide-sensitive soluble guanylate cyclase in monocrotaline-induced pulmonary hypertensive rats

Tawa M, Furukawa T, Tongu H, Sugihara M, Taguwa S, Yamanaka M, Yano Y, Matsumori H, Kitada R, Sawano T …

Life Sci 203 203-209 2018年査読有り
Sex differences in ischaemia/reperfusion-induced acute kidney injury depends on the degradation of noradrenaline by monoamine oxidase

Ryosuke Tanaka, Maki Yazawa, Yuri Morikawa, Hidenobu Tsutsui, Mamoru Ohkita, Tokihito Yukimura, Yasuo Matsumura

Clinical and Experimental Pharmacology and Physiology 44(3) 371-377 2017年3月1日査読有り
Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats

Shuhei Kobuchi, Ryosuke Tanaka, Takuya Shintani, Rie Suzuki, Hidenobu Tsutsui, Mamoru Ohkita, Yasuo Matsumura, Kazuhide Ayajiki

Clinical and Experimental Pharmacology and Physiology 42(3) 278-286 2015年3月1日査読有り

もっとみる

MISC

正常ラットに対する尿毒素indoxyl sulfate飲水投与が血管内皮機能に及ぼす影響

中川恵輔, 戸田成美, 小渕修平, 田和正志, 大喜多守

日本薬学会年会要旨集(Web) 143rd 2023年
α-Lipoic acid exerts a primary prevention for the cardiac dysfunction in aortocaval fistula-created rat hearts.

Daisuke Kurumazuka, Kento Kitada, Ryosuke Tanaka, Tatsuhiko Mori, Mamoru Ohkita, Masanori Takaoka, Yasuo Matsumura

Heliyon 5(8) e02371 2019年8月
心虚血再灌流障害におけるGPER活性化による心保護作用

澤野達哉, 大喜多守, 田和正志, 市原克則, 三明淳一朗, 今村武史, 松村靖夫

血管 42(1) 47-47 2019年1月
Sex differences in ischemia/reperfusion-induced acute kidney injury are dependent on the degradation of noradrenalin by monoamine oxidase

Ryosuke Tanaka, Maki Yazawa, Yuri Morikawa, Hidenobu Tsutsui, Mamoru Ohkita, Tokihito Yukimura, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 226P-226P 2014年
Effect of SM-368229, a novel mineralocorticoid receptor antagonist, in volume-overloaded rats with heart failure

Maki Koyama, Eiko Kawakami, Hiroto Akai, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 192P-192P 2014年
Activation of G protein-coupled estrogen receptor (GPER/GPR30) ameliorates myocardial ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow

Tatsuya Sawano, Masashi Tawa, Takeshi Koyama, Tomoyo Wada, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 158P-158P 2014年
Celiprolol attenuates hypoxia-induced left ventricular remodeling in mice

Satoshi Nishioka, Atsuo Nomura, Ryuji Kato, Masatoshi Miyamura, Mamoru Ohkita, Yoshikatsu Okada, Nobukazu Ishizaka, Tetsuya Hayashi, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 203P-203P 2013年
Role of superoxide in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts

Takeshi Koyama, Masashi Tawa, Akari Tsubota, Noriko Yamagishi, Tatsuya Sawano, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 162P-162P 2013年
Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice

S. Nishioka, T. Yoshioka, M. Ohkita, Y. Matsumura, N. Ishizaka, Y. Okada, T. Hayashi

EUROPEAN HEART JOURNAL 33 794-794 2012年8月
Endothelin-1 and norepinephrine overflow from cardiac sympathetic nerve endings in myocardial ischemia

Masashi Tawa, Satoshi Yamamoto, Mamoru Ohkita, Yasuo Matsumura

Cardiology Research and Practice 1(1) 2012年
Preventive effect of GGsTop (TM), a novel and selective gamma-glutamyl transpeptidase inhibitor, on ischemic acute kidney injury in rats

Ryosuke Tanaka, Shinya Yamamoto, Bunta Watanabe, Jun Hiratake, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 161P-161P 2012年
Gender difference of ischemia/reperfusion-induced acute kidney injury is dependent on renal sympathetic nervous system

Hidenobu Tsutsui, Ryosuke Tanaka, Toshihide Fujii, Shuhei Kobuchi, Takao Tanba, Yui Bonkohara, Masayo Yamagata, Mamoru Ohkita, Masanori Takaoka, Yasuo Matsumura …

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 212P-212P 2011年
L-Citrulline supplementation dose-dependently ameliorated renal injury in DOCA-salt hypertensive rats

Lisa Yamanaka, Ikumi Senzaki, Tomoki Hosokawa, Mamoru Ohkita, Masahiko Morita, Masayuki Ochiai, Koji Morishita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 161P-161P 2011年
Low salt condition deteriorates renal insufficiency induced by infusion of radiocontrast medium

Kenichi Hasegawa, Tatsuhiko Mori, Kento Kitada, Momoko Aoki, Yuri Kitikawa, Hirohisa Matsuda, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 213P-213P 2011年
gamma-Aminobutyric acid attenuates monocrotaline-induced pulmonary hypertension in rats by suppressing plasma norepinephrine level

Rie Suzuki, Rumi Maehara, Shuhei Kobuchi, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 151P-151P 2011年
Role of angiotensin II on norepinephrine release induced by perivascular nerve stimulation in the rat mesenteric artery

Yuri Nishimura, Akiko Minami, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 152P-152P 2011年
Protective effect of 17 beta-estradiol on ischemic acute kidney injury through renal sympathetic nervous system

Ryosuke Tanaka, Hidenobu Tsutsui, Takahiro Sugiura, Shuhei Kobuchi, Asami Funai, Masayo Yamagata, Mamoru Ohkita, Masanori Takaoka, Tokihito Yukimura, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 161P-161P 2011年
Acarbose prevents postprandial hyperglycemia and left ventricular remodeling accelerated by intermittent hypoxia in lean mice

Toshitaka Yoshioka, Kenichi Hasegawa, Mamoru Ohkita, Yasuo Matsumura

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 155P-155P 2011年
Preventive effect of AK2-110, a novel .GAMMA.-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats

YAMAMOTO Shinya, WATANABE Bunta, HIRATAKE Jun, OHKITA Mamoru, MATSUMURA Yasuo

J Pharmacol Sci 112(Supplement 1) 152P 2010年2月15日
ラット腎虚血再灌流障害に対する内因性モノアミンオキシダーゼ阻害物質イサチンの効果

三浦健, 三浦健, 筒居秀伸, 筒居秀伸, 小渕修平, 田中亮輔, 山形雅代, 大喜多守, 松村靖夫, 雪村時人 …

日本薬学会年会要旨集 130th(3) 2010年

もっとみる

共同研究・競争的資金等の研究課題

エンドセリンとエストロゲンによる虚血性臓器障害の制御と性差

日本学術振興会科学研究費助成事業基盤研究(C) 2015年4月 - 2018年3月

大喜多守
一酸化窒素産生を絶対的に支配するエンドセリン－１およびその受容体の意義

日本学術振興会科学研究費助成事業基盤研究(C) 2011年 - 2013年

大喜多守, 松村靖夫
虚血性臓器障害と交感神経:エンドセリンおよびアンジオテンシン系の役割と性差

日本学術振興会科学研究費助成事業基盤研究(C) 2008年 - 2010年

松村靖夫, 大喜多守

大喜多守

基本情報

研究分野

経歴

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧