論文

査読有り 国際誌
2017年5月

Association between preoperative characteristics and risk of anaesthesia-related death in dogs in small-animal referral hospitals in Japan.

Veterinary anaesthesia and analgesia
  • Takaharu Itami
  • Hiroko Aida
  • Makoto Asakawa
  • Yoko Fujii
  • Tomoya Iizuka
  • Ayako Imai
  • Toshie Iseri
  • Tomohito Ishizuka
  • Kei Kakishima
  • Masatoshi Kamata
  • Takako Miyabe-Nishiwaki
  • Shotaro Nagahama
  • Kiyokazu Naganobu
  • Ryohei Nishimura
  • Shozo Okano
  • Tadashi Sano
  • Kazuto Yamashita
  • Yoshiki Yamaya
  • Masashi Yanagawa
  • 全て表示

44
3
開始ページ
461
終了ページ
472
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.vaa.2016.08.007
出版者・発行元
ELSEVIER

OBJECTIVE: To explore the major risk factors linking preoperative characteristics and anaesthesia-related death in dogs in referral hospitals in Japan. STUDY DESIGN: Observational cohort study. ANIMALS: From April 1, 2010 to March 31, 2011, 4323 dogs anaesthetized in 18 referral hospitals in Japan. METHODS: Questionnaire forms were collated anonymously. Death occurring within 48 hours after extubation was considered as an anaesthesia-related death. Patient outcome (alive or dead) was set as the outcome variable. Preoperative general physical characteristics, complete blood cell counts, serum biochemical examinations and intraoperative complications were set as explanatory variables. The risk factors for anaesthesia-related death were evaluated using chi-square test or Fisher's exact test, followed by multivariable logistic regression analysis of the data. Significance was set at p < 0.05. RESULTS: Thirteen dogs that died from surgical error or euthanasia were excluded from statistical analysis. The total mortality rate in this study was 0.65% [28/4310 dogs; 95% confidence interval (CI), 0.41-0.89]. Furthermore, 75% (95% CI, 55.1-89.3) of anaesthesia-related deaths occurred in dogs with pre-existing diseases. Most of the deaths occurred postoperatively (23/28; 82.1%; 95% CI, 63.1-93.9). Preoperative serum glucose concentration <77 mg dL-1 (6/46; 13.0%; 95% CI, 4.9-26.3), disturbance of consciousness (6/50; 12.0%; 95% CI, 4.5-24.3), white cell count >15,200 μL-1 (16/499; 3.4%; 95% CI, 1.9-5.5) and American Society of Anesthesiologists grade III-V (19/1092; 1.7%; 95% CI, 1.1-2.7) were identified as risk factors for anaesthesia-related death. Intraoperative hypoxaemia (8/34; 23.5%; 95% CI, 10.7-41.2) and tachycardia (4/148; 2.7%; 95% CI, 0.7-6.8) were also risk factors for anaesthesia-related death. CONCLUSIONS AND CLINICAL RELEVANCE: The results revealed that certain preoperative characteristics were associated with increased odds of anaesthesia-related death, specifically low serum glucose concentration and disturbances of consciousness. Greater attention to correcting preanaesthetic patient abnormalities may reduce the risk of anaesthesia-related death.

リンク情報
DOI
https://doi.org/10.1016/j.vaa.2016.08.007
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28579007
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000423289500008&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029660123&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85029660123&origin=inward
ID情報
  • DOI : 10.1016/j.vaa.2016.08.007
  • ISSN : 1467-2987
  • eISSN : 1467-2995
  • PubMed ID : 28579007
  • SCOPUS ID : 85029660123
  • Web of Science ID : WOS:000423289500008

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