DONGQING PAN

Profile Information

Affiliation: Chugai Pharmaceutical Co., Ltd.

Degree: 薬学博士(京都大学)

ORCID ID: https://orcid.org/0000-0003-3701-8442
J-GLOBAL ID: 201901014401979669
researchmap Member ID: B000369045

Research Interests

晶構造解析、細胞小器官、ペルオキシソーム、キネトコア、化学架橋質量分析 biochemistry, structural biology, protein complex, membrane protein, X-ray crystallography, organelle, peroxisome, kinetochore, cross-linking mass spectrometry

Research Areas

Life sciences / Structural biochemistry /

Research History

Sep, 2019 - Sep, 2022

助教, 構造生物薬学分野, 京都大学大学院薬学研究科
Apr, 2014 - Sep, 2019

Postdoctral fellow, Department of Mechanistic Cell Biology, Max-Planck Institute of Molecular Physiology
Apr, 2013 - Mar, 2014

特定研究員, 構造生物薬学分野, 京都大学大学院薬学研究科

Education

Apr, 2010 - Mar, 2013

Graduate School of Pharmaceutical Sciences, Kyoto University
Apr, 2008 - Mar, 2010

Graduate School of Science, Nagoya University
Apr, 2004 - Mar, 2008

Department of Biological Science, School of Science, Nagoya University

Papers

Structure‐based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy

Yoshiki Inoue, Tomohiro Yamaguchi, Tetsuo Otsuka, Yuto Utsunomiya, Dongqing Pan, Haruo Ogawa, Hiroaki Kato

Protein Science, 31(6), Jun, 2022
Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX

Dongqing Pan, Ryo Oyama, Tomomi Sato, Takanori Nakane, Ryo Mizunuma, Keita Matsuoka, Yasumasa Joti, Kensuke Tono, Eriko Nango, So Iwata …

IUCrJ, 9(1) 134-145, Jan 1, 2022 Peer-reviewedLead author
Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly

Johannes van den Boom, Anja F. Kueck, Bojana Kravic, Helen Müschenborn, Maike Giesing, Dongqing Pan, Farnusch Kaschani, Markus Kaiser, Andrea Musacchio, Hemmo Meyer

Nature Structural & Molecular Biology, Nov 25, 2021 Peer-reviewed
Assembly principles and stoichiometry of a complete human kinetochore module

Kai Walstein, Arsen Petrovic, Dongqing Pan, Birte Hagemeier, Dorothee Vogt, Ingrid R. Vetter, Andrea Musacchio

Science Advances, 7(27) eabg1037-eabg1037, Jun, 2021 Peer-reviewed
Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly

María Ascensión Villar-Fernández, Richard Cardoso da Silva, Magdalena Firlej, Dongqing Pan, Elisabeth Weir, Annika Sarembe, Vivek B Raina, Tanja Bange, John R Weir, Gerben Vader

Life Science Alliance, 3(11) e201900630-e201900630, Nov, 2020 Peer-reviewed
Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA.

Muwen Kong, Erin E Cutts, Dongqing Pan, Fabienne Beuron, Thangavelu Kaliyappan, Chaoyou Xue, Edward P Morris, Andrea Musacchio, Alessandro Vannini, Eric C Greene

Molecular cell, 79(1) 99-114, Jul 2, 2020 Peer-reviewed
Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Dongqing Pan, Kai Walstein, Annika Take, David Bier, Nadine Kaiser, Andrea Musacchio

Nature Communications, 10(1), Dec, 2019 Peer-reviewedLead authorCorresponding author
Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link Identification.

Pan D, Brockmeyer A, Mueller F, Musacchio A, Bange T

Analytical chemistry, Aug, 2018 Peer-reviewedLead authorCorresponding author
Experimental phase determination with selenomethionine or mercury-derivatization in serial femtosecond crystallography

Keitaro Yamashita, Naoyuki Kuwabara, Takanori Nakane, Tomohiro Murai, Eiichi Mizohata, Michihiro Sugahara, Dongqing Pan, Tetsuya Masuda, Mamoru Suzuki, Tomomi Sato …

IUCRJ, 4 639-647, Sep, 2017 Peer-reviewed
CDK-regulated dimerization of M18BP1 on a Mis 18 hexamer is necessary for CENP-A loading

Dongqing Pan, Kerstin Klare, Arsen Petrovic, Annika Take, Kai Walstein, Priyanka Singh, Arnaud Rondelet, Alexander W. Bird, Andrea Musacchio

ELIFE, 6, Jan, 2017 Peer-reviewedLead authorCorresponding author
Insights from biochemical reconstitution into the architecture of human kinetochores

John R. Weir, Alex C. Faesen, Kerstin Klare, Arsen Petrovic, Federica Basilico, Josef Fischboeck, Satyakrishna Pentakota, Jenny Keller, Marion E. Pesenti, Dongqing Pan …

NATURE, 537(7619) 249-+, Sep, 2016 Peer-reviewed
An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography

Keitaro Yamashita, Dongqing Pan, Tomohiko Okuda, Michihiro Sugahara, Atsushi Kodan, Tomohiro Yamaguchi, Tomohiro Murai, Keiko Gomi, Naoki Kajiyama, Eiichi Mizohata …

SCIENTIFIC REPORTS, 5, Sep, 2015 Peer-reviewed
Luciferin-regenerating enzyme solved by SIRAS using XFEL (refined against Hg derivative data)

Yamashita K, Pan D, Okuda T, Sugahara M, Kodan A, Yamaguchi T, Murai T, Gomi K, Kajiyama N, Mizohata E …

Worldwide Protein Data Bank, 2015 Peer-reviewed
Luciferin-regenerating enzyme solved by SAD using synchrotron radiation at room temperature

Yamashita K, Pan D, Okuda T, Sugahara M, Kodan A, Yamaguchi T, Murai T, Gomi K, Kajiyama N, Mizohata E …

Worldwide Protein Data Bank, 2015 Peer-reviewed
Grease matrix as a versatile carrier of proteins for serial crystallography

Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masudala, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno …

NATURE METHODS, 12(1) 61-63, Jan, 2015 Peer-reviewed
Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p

Dongqing Pan, Toru Nakatsu, Hiroaki Kato

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 20(8) 987-+, Aug, 2013 Peer-reviewedLead authorCorresponding author
Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2

Dongqing Pan, Yoshiyuki Matsuura

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 68(4) 386-392, Apr, 2012 Peer-reviewedLead author

Misc.

ABCトランスポーターとの共結晶形成を指向したローダミン誘導体の合成と評価

三和空知, 瀧川紘, 竹内莉奈, 小田島圭, 水沼諒, 山岡庸介, 潘東青, 加藤博章, 高須清誠

次世代を担う有機化学シンポジウム講演要旨集, 20th, 2022
ペルオキシソームへのタンパク質輸送に関わる Pex1p:Pex6p:Pex15p複合体の再構成

中村優作, 加藤博章, 潘東青

日本生化学会第94回日本生化学会大会, Nov, 2021
ABC 多剤排出トランスポーター薬物複合体の X 線結晶構造解析

水沼諒, 小田島圭, 三和空知, 潘東青, 瀧川紘, 中津亨, 高須清誠, 加藤博章

第 42 回生体膜と薬物の相互作用シンポジウム, 42nd (CD-ROM), Oct, 2021
Crystal structure of multidrug transporter CmABCB1 and substrate analogs

水沼諒, 小田島圭, 三和空知, PAN Dongqing, 瀧川紘, 中津亨, 中津亨, 高須清誠, 加藤博章, 加藤博章

日本薬学会年会要旨集(Web), 141st, Mar, 2021
Identification of substrate binding sites in P-glycoprotein, CmABCB1 with affinity-labeling

小田島圭, PAN Dongqing, 三和空知, 水沼諒, 瀧川紘, 高須清誠, 加藤博章, 加藤博章

日本薬学会年会要旨集(Web), 141st, Mar, 2021
ナノディスクに挿入したP糖タンパク質CmABCB1のATPase活性に対する脂質成分の影響

陳月, 潘東青, 加藤博章

日本薬学会第141年会(広島), Mar, 2021
Purification and biochemical characterization of Candida albicans Cdr1p multi-drug exporter.

筒井隼一, CHEN Yue, 中津亨, 中津亨, 加藤博章, 加藤博章, PAN Dongqing

日本薬学会年会要旨集(Web), 141st, Mar, 2021 Last author
ヒト CENP-A補填複合体の形成におけるHJURPとMis18複合体の相互作用機構

潘東青, Kai Walstein, Annika Take, David Bier, Nadine Kaiser, Andrea Musacchio

第93回日本生化学会大会, Sep, 2020 Lead author
Affinity-labeling of the poly-specific substrate binding site in P-glycoprotein, CmABCB1

小田島圭, PAN Dongqing, 三和空知, 水沼諒, 瀧川紘, 高須清誠, 加藤博章, 加藤博章

日本薬学会年会要旨集(CD-ROM), 140th, 2020
Synthesis and structure-ATPase activity relationship of rhodamine derivatives against P-glycoprotein CmABCB1

瀧川紘, 三和空知, 竹内莉奈, 山岡庸介, PAN Dongqing, 中津亨, 加藤博章, 高須清誠

複素環化学討論会講演要旨集, 49th, 2020
Functional investigation of transmembrane helix 4 of thermophilic P-glycoprotein CmABCB1

水沼諒, 井上善貴, 松岡敬太, Pan Dongqing, 中津亨, 中津亨, 加藤博章, 加藤博章

日本薬学会年会要旨集(CD-ROM), 140th, 2020
Dynamic process of CDK-regulated assembly of the CENP-A deposition machinery

Dongqing Pan, Kerstin Klare、Arsen Petrovic、Annika Take, Kai Walstein, Priyanka Singh, Arnaud Rondelet、Alexander Bird, Andrea Musacchio

Dec, 2017 Lead author
X線自由電子レーザーを用いた新規タンパク質の立体構造決定

日本薬学会年会要旨集(CD-ROM), 136年会(2) 249-249, Mar, 2016
シリアル結晶学における重原子誘導体を用いた位相決定

山下恵太郎, 潘東青, 長谷川和也, 菅原道泰, 村井智洋, 小段篤史, 溝端栄一, 鈴木守, 鈴木守, 桝田哲哉 …

日本結晶学会年会講演要旨集, 2015 89, Oct, 2015
De novo structure determination for serial femtosecond crystallography using heavy atom derivatives

YAMASHITA Keitaro, PAN Dongqing, SUGAHARA Michihiro, AGO Hideo, YAMAMOTO Masaki, NAKATSU Toru, NAKATSU Toru

生物物理(Web), 55(Supplement 1-2) 1SGP-04 (WEB ONLY), Aug 18, 2015
シリアルフェムト秒X線結晶構造解析のための試料調製方法

田中智之, 菅原道泰, 山下鮎美, 小林淳, 田中里枝, 登野健介, 城地保昌, 亀島敬, PARK Jaehyun, SONG Changyong …

日本蛋白質科学会年会プログラム・要旨集, 15th 95, May 26, 2015
X 線自由電子レーザーを用いたタンパク質 X 線結晶構造解析

潘東青, 中津亨, 山口知宏, 小段篤史, 小川和浩, 松嶌一樹, 山下恵太郎, 城地保昌, 登野健介, 矢橋牧名 …

日本薬学会第135年会, Mar 27, 2015
SACLAによるABCトランスポーターおよびホタル・ルシフェラーゼのX線結晶構造解析(第2報)

潘東青, 中津亨, 山口知宏, 小段篤史, 小川和浩, 松嶌一樹, 山下恵太郎, 城地保昌, 登野健介, 矢橋牧名 …

平成26年度日本結晶学会年会, 14th, Nov 1, 2014
XFELを用いた創薬ターゲット蛋白質の迅速構造解析法の開発

南後恵理子, 田中智之, 鈴木守, 鈴木守, 桝田哲哉, 桝田哲哉, 山下鮎美, 田中里枝, 登野健介, 城地保昌 …

日本蛋白質科学会年会プログラム・要旨集, 14th, 2014
創薬ターゲット蛋白質の迅速構造解析法の開発~SACLAにおけるシリアルフェムト秒X線結晶構造解析~

南後恵理子, 鈴木守, 田中里枝, 登野健介, 城地保昌, 亀島敬, PARK Jaehyun, SONG Changyong, 初井宇記, 矢橋牧名 …

日本結晶学会年会講演要旨集,2013,92, 2013, 2013

Professional Memberships

日本生化学会

Research Projects

ペルオキシンリサイクル複合体の構造と制御機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

潘東青
Structural basis for alternating access mechanism of ABC multi-drug pump in lipid membrane

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Biochemical study of the AAA-ATPase complex in peroxisome protein import

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022

Pan Dongqing

Profile Information

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Research Areas

Research History

Education

Papers

Misc.

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