2012年9月
Diagnosis of autoimmune pancreatitis by EUS-FNA by using a 22-gauge needle based on the International Consensus Diagnostic Criteria
GASTROINTESTINAL ENDOSCOPY
- 巻
- 76
- 号
- 3
- 開始ページ
- 594
- 終了ページ
- 602
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.gie.2012.05.014
- 出版者・発行元
- MOSBY-ELSEVIER
Background: It is controversial whether EUS-guided FNA by using 22-gauge (G) needles is useful for the diagnosis or evaluation of autoimmune pancreatitis (AIP).
Objective: To evaluate the usefulness of EUS-FNA by 22-G needles for the histopathological diagnosis of AIP.
Design: A retrospective study.
Setting: Single academic center.
Patients: A total of 273 patients, including 25 with AIP, underwent EUS-FNA and histological examinations.
Results: EUS-FNA by using 22-G needles provided adequate tissue samples for histopathological evaluation because more than 10 high-power fields were available for evaluation in 20 of 25 patients (80%). The mean immunoglobulin G4-positive plasma cell count was 13.7/high-power field. Obliterative phlebitis was observed in 10 of 25 patients (40%). In the context of the International Consensus Diagnostic Criteria for AIP, 14 and 6 of 25 patients were judged to have level 1 (positive for 3 or 4 items) and level 2 (positive for 2 items) histological findings, respectively, meaning that 20 of 25 patients were suggested to have lymphoplasmacytic sclerosing pancreatitis based on the International Consensus Diagnostic Criteria. The diagnosis in 1 patient was type 2 AIP because a granulocytic epithelial lesion was identified in this patient.
Limitations: A retrospective study with a small number of patients.
Conclusions: The results of this study suggest that EUS-FNA by using 22-G needles provides tissue samples adequate for histopathological evaluation and greatly contributes to the histological diagnosis of AIP. (Gastrointest Endosc 2012;76:594-602.)
Objective: To evaluate the usefulness of EUS-FNA by 22-G needles for the histopathological diagnosis of AIP.
Design: A retrospective study.
Setting: Single academic center.
Patients: A total of 273 patients, including 25 with AIP, underwent EUS-FNA and histological examinations.
Results: EUS-FNA by using 22-G needles provided adequate tissue samples for histopathological evaluation because more than 10 high-power fields were available for evaluation in 20 of 25 patients (80%). The mean immunoglobulin G4-positive plasma cell count was 13.7/high-power field. Obliterative phlebitis was observed in 10 of 25 patients (40%). In the context of the International Consensus Diagnostic Criteria for AIP, 14 and 6 of 25 patients were judged to have level 1 (positive for 3 or 4 items) and level 2 (positive for 2 items) histological findings, respectively, meaning that 20 of 25 patients were suggested to have lymphoplasmacytic sclerosing pancreatitis based on the International Consensus Diagnostic Criteria. The diagnosis in 1 patient was type 2 AIP because a granulocytic epithelial lesion was identified in this patient.
Limitations: A retrospective study with a small number of patients.
Conclusions: The results of this study suggest that EUS-FNA by using 22-G needles provides tissue samples adequate for histopathological evaluation and greatly contributes to the histological diagnosis of AIP. (Gastrointest Endosc 2012;76:594-602.)
- リンク情報
- ID情報
-
- DOI : 10.1016/j.gie.2012.05.014
- ISSN : 0016-5107
- PubMed ID : 22898417
- Web of Science ID : WOS:000307948600020