ロッブポーリン (Pauline Robbe) - マイポータル

基本情報

所属: 特定国立研究開発法人理化学研究所生命医科学研究センター（IMS）

J-GLOBAL ID: 202301011814022544
researchmap会員ID: R000054499

研究キーワード

研究分野

経歴

2020年 - 2023年

特定国立研究開発法人理化学研究所, 生命医科学研究センター（IMS）
2018年 - 2020年

特定国立研究開発法人理化学研究所, 生命医科学研究センター（IMS）
2018年 - 2018年

University of Oxford, Radcliffe department of Medicine (Postgraduate research assistant)
2011年 - 2018年

University of Oxford, Radcliffe department of Medicine (Research assistant)
2010年 - 2011年

Sanofi R&D (Research assistant)

学歴

2014年 - 2018年

University of Oxford, Medical Sciences, Doctoral degree
2009年 - 2011年

University of Montpellier, Masters degree
2006年 - 2009年

University of Montpellier, Undergraduate degree

受賞

2024年

高松宮妃癌研究基金
2023年

ASH Abstract Achievement Award, American Society of Hematology
2023年

Hamblin Prize, UK CLL Forum
2023年

Best Symposium award Diamond, 日本血液学会
2023年

Grant-in-Aid for Early-Career Scientists, JSPS
2022年

ASH Travel Award, UK CLL Forum
2021年

Young researcher grant, MSD Life Science Foundation
2018年

Postdoctoral fellowship, JSPS
2016年

Travel and Research Fund award, St Cross College, University of Oxford, UK.

論文

Genomic Stratification of Hematological Malignancies.

Pauline Robbe, Anna Schuh

HemaSphere 7(6) e902 2023年6月
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.

Pauline Robbe, Kate E Ridout, Dimitrios V Vavoulis, Helene Dréau, Ben Kinnersley, Nicholas Denny, Daniel Chubb, Niamh Appleby, Anthony Cutts, Alex J Cornish …

Nature genetics 54(11) 1675-1689 2022年11月
Long-term follow-up of 415 patients with chronic lymphocytic leukemia treated with fludarabine and cyclophosphamide-based chemoimmunotherapy in the frontline ADMIRE and ARCTIC trials: A comprehensive assessment of prognostic factors.

David John Allsup, Zoe Craig, David Cairns, Dena Howard, Anna Hockaday, Adrian Bloor, Zarni Soe, Christopher Pepper, Valter Gattei, Antonella Zucchetto …

American journal of hematology 97(5) E168-E171 2022年5月
Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia.

Jenny Klintman, Niamh Appleby, Basile Stamatopoulos, Katie Ridout, Toby A Eyre, Pauline Robbe, Laura Lopez Pascua, Samantha J L Knight, Helene Dreau, Maite Cabes …

Blood 137(20) 2800-2816 2021年5月20日
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.

Wei-Yu Lin, Sarah E Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock …

Nature communications 12(1) 665-665 2021年1月28日
Comparative analysis of somatic variant calling on matched FF and FFPE WGS samples.

Louise de Schaetzen van Brienen, Maarten Larmuseau, Kim Van der Eecken, Frederic De Ryck, Pauline Robbe, Anna Schuh, Jan Fostier, Piet Ost, Kathleen Marchal

BMC medical genomics 13(1) 94-94 2020年7月6日
Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial.

Stuart J Blakemore, Ruth Clifford, Helen Parker, Pavlos Antoniou, Ewa Stec-Dziedzic, Marta Larrayoz, Zadie Davis, Latha Kadalyayil, Andrew Colins, Pauline Robbe …

Leukemia 34(7) 1760-1774 2020年7月
Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials.

Tomasz K Wojdacz, Harindra E Amarasinghe, Latha Kadalayil, Alice Beattie, Jade Forster, Stuart J Blakemore, Helen Parker, Dean Bryant, Marta Larrayoz, Ruth Clifford …

Blood advances 3(16) 2474-2481 2019年8月27日
The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study.

Basile Stamatopoulos, Thomas Smith, Emerence Crompot, Karlien Pieters, Ruth Clifford, Marek Mraz, Pauline Robbe, Adam Burns, Adele Timbs, David Bruce …

Clinical cancer research : an official journal of the American Association for Cancer Research 24(20) 5048-5057 2018年10月15日
Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project.

Pauline Robbe, Niko Popitsch, Samantha J L Knight, Pavlos Antoniou, Jennifer Becq, Miao He, Alexander Kanapin, Anastasia Samsonova, Dimitrios V Vavoulis, Mark T Ross …

Genetics in medicine : official journal of the American College of Medical Genetics 20(10) 1196-1205 2018年10月
Clinical-grade validation of whole genome sequencing reveals robust detection of low-frequency variants and copy number alterations in CLL.

Jenny Klintman, Katerina Barmpouti, Samantha J L Knight, Pauline Robbe, Hélène Dreau, Ruth Clifford, Kate Ridout, Adam Burns, Adele Timbs, David Bruce …

British journal of haematology 182(3) 412-417 2018年8月
Using Genomic Information to Guide Ibrutinib Treatment Decisions in Chronic Lymphocytic Leukaemia: A Cost-Effectiveness Analysis.

James Buchanan, Sarah Wordsworth, Ruth Clifford, Pauline Robbe, Jenny C Taylor, Anna Schuh, Samantha J L Knight

PharmacoEconomics 35(8) 845-858 2017年8月
Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL.

Romain Guièze, Pauline Robbe, Ruth Clifford, Sophie de Guibert, Bruno Pereira, Adele Timbs, Marie-Sarah Dilhuydy, Maite Cabes, Loïc Ysebaert, Adam Burns …

Blood 126(18) 2110-7 2015年10月29日
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

Ruth Clifford, Tania Louis, Pauline Robbe, Sam Ackroyd, Adam Burns, Adele T Timbs, Glen Wright Colopy, Helene Dreau, Francois Sigaux, Jean Gabriel Judde …

Blood 123(7) 1021-31 2014年2月13日

講演・口頭発表等

Genomic Complexity by NGS, how does it relate to karyotype?

ESH 3rd Translational Research Conference: Chronic Lymphocytic Leukaemia, Vienna, Austria 2024年招待有り
Whole Genome Classification of Pre-Malignant B-Cells Disorder of the Oxplored Study

65th ASH Annual Meeting & Exposition, San Diego, USA. 2023年12月
Whole-Genome Analysis of CLL and Interplay of Coding, Non-Coding, Transcriptome and Epigenetic Events

International Workshop on Chronic Lymphocytic Leukemia, Boston, USA 2023年招待有り
Activity of immune cells in tissue adjacent to liver cancer

26th RIKEN Interdisciplinary Exchange Evening, Wako, Japan 2023年
Risk-stratification of chronic lymphocytic leukaemia using whole-genome sequencing

Japanese society of Hematology International symposium, Tsukuba, Japan 2023年
Subclassifying CLL using whole genome sequencing

American society of Hematology congress, New-Orleans, USA 2022年招待有り
Involvement of specific clusters of immune cells in tissues adjacent to hepatocellular carcinoma revealed by single-cell transcriptomics

European Association for Cancer Research – Cancer genomics research, Oxford, UK 2022年
Dysregulation of non-coding regulatory elements in hepatocellular carcinoma revealed by genomics and transcriptomics

European Association for Cancer Research, Innovative Cancer 2021年
Dysregulation of regulatory elements in hepatocellular carcinoma

8th RIKEN Life Science Retreat 2020年
Patient stratification based on WGS data incorporating multiple genomic features in a single test

European Association for Cancer Research, Cancer Genomics Cambridge, UK 2019年
Investigation of novel drivers in chronic lymphocytic leukaemia using whole genome sequencing

CSHL Genome Informatics meeting, Cold Spring Harbor, USA 2019年
Identifying high-risk CLL using Whole Genome Sequencing

3rd International Conference on New Concepts in Lymphoid Malignancies. Mandelieu. FRANCE. 2018年
Whole genome sequencing in the clinic for CLL patients

British Society for Haematology 58thAnnual Scientific Meeting. Liverpool. UK 2018年
Optimisation of Copy Number Alterations detection from FFPE data for clinical reporting of whole genome sequencing of renal cancer patients

Radcliffe Department of Medicine Annual Symposium Oxford, UK. 2017年
Clinical whole genome sequencing of renal cancer patients in routine diagnostic

Department of Oncology Annual Symposium Oxford, UK. 2017年
Application of genomics in the cancer clinic: challenges and progress

RIKEN, Yohohama. JAPAN 2017年招待有り
Clinical grade whole genome sequencing from FFPE specimen for cancer patients.

13th Medical Sciences Division DPhil Day Oxford, UK. 2016年
Identifying High-Risk CLL to Predict Early Relapse after FCR Based Treatment Using Whole Genome Sequencing: Results from the 100,000 Genomes project.

American Society of Hematology annual meeting - San Diego, USA. 2016年
Generation of high-quality DNA from formalin-fixed paraffin embedded tissue for clinical grade whole genome sequencing.

International congress of human genetics - Kyoto, JAPAN. 2016年
Getting personal: DNA driven treatments for leukaemia.

Wellcome Trust Centre for Human Genetics Spotlight series: Translational Genetics. Oxford, UK 2016年招待有り

もっとみる

担当経験のある科目(授業)

2021年 - 現在

Lecturer for the MSc Precision Cancer Medicine (University of Oxford, UK)

所属学協会

2023年 - 現在

The European Hematology Association
2023年 - 現在

日本血液学会
2019年 - 現在

The European Association for Cancer Research

メディア報道

全ゲノム解析による慢性リンパ性白血病患者の層別化に成功

https://www.riken.jp/press/2022/20221111_1/index.html 2022年インターネットメディア