2010年
SAXS and SANS Observations of Abnormal Aggregation of Human alpha-Crystallin
CHEMISTRY & BIODIVERSITY
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- 巻
- 7
- 号
- 6
- 開始ページ
- 1380
- 終了ページ
- 1388
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/cbdv.200900332
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Aggregation states of human alpha-crystallins are observed complementarily using small-angle X-ray and small-angle neutron scatterings (SAXS and SANS). Infant alpha-crystallin is almost a monodispersed system of the aggregates with gyration radius of ca. 60 angstrom, which is a normal aggregate. On the other hand, the aged and cataract alpha-crystallins have not only the normal but also the larger aggregates. In the aged alpha-crystallin, the normal aggregate is a major component, but in the cataract alpha-crystallin the larger ones are dominant. Both alpha A- and alpha B-crystallins, which are subunits of alpha-crystallin, also form an aggregate with the size close to the normal aggregate. Under UV irradiation, only aggregates of alpha B-crystallin undergo further aggregation. Therefore, considering increase of ratio of aB-crystallin in the aggregate of alpha-crystallin as aging, the abnormal aggregation (formation of the huge aggregates) mainly results in thefurther aggregation of alpha B-crystallin caused by external stresses.
- リンク情報
- ID情報
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- DOI : 10.1002/cbdv.200900332
- ISSN : 1612-1872
- eISSN : 1612-1880
- PubMed ID : 20564557
- Web of Science ID : WOS:000281310800007