2014年
Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: A fNIRS study
NEUROIMAGE-CLINICAL
- 巻
- 6
- 号
- 開始ページ
- 192
- 終了ページ
- 201
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.nicl.2014.09.001
- 出版者・発行元
- ELSEVIER SCI LTD
The object of the current study is to explore the neural substrate for effects of atomoxetine (ATX) on inhibitory control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional nearinfrared spectroscopy (fNIRS). We monitored the oxy-hemoglobin signal changes of sixteen ADHD children (6-14 years old) performing a go/no-go task before and 1.5 h after ATX or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Sixteen age-and gender-matched normal controls without ATX administration were also monitored. In the control subjects, the go/no-go task recruited the right inferior and middle prefrontal gyri (IFG/MFG), and this activation was absent in pre-medicated ADHD children. The reduction of right IFG/MFG activation was acutely normalized after ATX administration but not placebo administration in ADHD children. These results are reminiscent of the neuropharmacological effects of methylphenidate to up-regulate reduced right IFG/MFG function in ADHD children during inhibitory tasks. As with methylphenidate, activation in the IFG/MFG could serve as an objective neuro-functional biomarker to indicate the effects of ATX on inhibitory control in ADHD children. This promising technique will enhance early clinical diagnosis and treatment of ADHD in children, especially in those with a hyperactivity/impulsivity phenotype. (C) 2014 The Authors. Published by Elsevier Inc.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.nicl.2014.09.001
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/25379431
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215398
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000349668500022&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.nicl.2014.09.001
- ISSN : 2213-1582
- PubMed ID : 25379431
- PubMed Central 記事ID : PMC4215398
- Web of Science ID : WOS:000349668500022